Journal of Fluorine Chemistry p. 179 - 183 (1993)
Update date:2022-08-17
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Tolman, V.
Synthetic methods for the preparation of 4-fluoroglutamic acid (1) are reviewed.The utility of every method for routine laboratory work is evaluated with respect to the accessibility of starting materials and reagents, the overall yields and also from the viewpoint of safety.Optimum reaction conditions are given for the selected pathway, suitable for large-scale synthesis.
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