156-10-5

Basic information

• Product Name: 4-NITROSODIPHENYLAMINE
• Synonyms: 4-NITROSO-N-PHENYLANILINE;4-NITROSODIPHENYLAMINE;P-NITROSODIPHENYLAMINE;4-Niinylamine;4-nitroso-diphenylamin;4-nitroso-n-phenyl-benzenamin;4-Nitroso-N-phenylbenzenamine;diphenyl,4-nitroso-amin
• CAS NO: 156-10-5
• Molecular Formula: C₁₂H₁₀N₂O
• Molecular Weight: 198.22
• EINECS: 205-848-7
• Product Categories: Nitrogen Compounds;Nitroso Compounds;Organic Building Blocks
• Mol File: 156-10-5.mol
• Article Data: 27

Chemical Properties

• Melting Point: 144 °C (dec.)(lit.)
• Boiling Point: 335.53°C (rough estimate)
• Flash Point: 169.5°C
• Appearance: /
• Density: 1.1447 (rough estimate)
• Vapor Pressure: 2.86E-05mmHg at 25°C
• Refractive Index: 1.6330 (estimate)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly, Sonicated)
• PKA: -3.56±0.20(Predicted)
• Merck: 14,6639
• CAS DataBase Reference: 4-NITROSODIPHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITROSODIPHENYLAMINE(156-10-5)
• EPA Substance Registry System: 4-NITROSODIPHENYLAMINE(156-10-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/38
• Safety Statements: 26-36/37
• RIDADR: 2811
• WGK Germany: 3
• RTECS: JK0175000
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 156-10-5(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 156-10-5 differently. You can refer to the following data:
1. dark blue to black powder
2. TKB is a black powder or a green plate-like material with a bluish luster.

Uses

Different sources of media describe the Uses of 156-10-5 differently. You can refer to the following data:
1. 4-?Nitrosodiphenylamine is used in organic synthesis such as in the preparation of 1-(Phenylamino)pseudo-mauveine water soluble dye. Potential mutagenic compound.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.
2. Has been used as retardant in vulcanizing rubber.

Synthesis Reference(s)

The Journal of Organic Chemistry, 32, p. 153, 1967 DOI: 10.1021/jo01277a038

General Description

Green plates with bluish luster or a black powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-NITROSODIPHENYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. May react with strong oxidizing agents .

Hazard

Questionable carcinogen.

Fire Hazard

Flash point data for 4-NITROSODIPHENYLAMINE are not available; however, 4-NITROSODIPHENYLAMINE is probably combustible.

Safety Profile

Poison by intravenous route. Suspected carcinogen with experimental carcinogenic and neoplastigenic data. Moderately toxic by ingestion. Mutation data reported. An eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also NNITROSO COMPOUNDS and AMINES.

Potential Exposure

Used as a chemical intermediate for dyes and pharmaceuticals; in making monomers; and vulcanizing rubber.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Purification Methods

The amine forms dark green crystals from EtOH or *C6H6 (m 143o). It has UV at max 421nm (EtOH) and is used for detecting Pd and Rh. It is highly toxic and a possible carcinogen.[Beilstein 12 H 207, 12 II 122, 12 III 347, 12 IV 1860..]

Incompatibilities

Nitrated organics range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction. Reaction with aliphatic amines can release carcinogenic nitrosamines. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. 4-nitrosodiphenylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrideds and active metals. May react with strong oxidizing agents.

InChI:InChI=1/C12H10N2O/c15-14-12-8-6-11(7-9-12)13-10-4-2-1-3-5-10/h1-9,13H

Synthetic route

nitrobenzene (98-95-3) + bis(diphenyl)urea (102-07-8) → p-nitrosodiphenylamine (156-10-5)

Conditions	Yield
With oxygen; sodium hydroxide In dimethyl sulfoxide at 60℃; for 4h; Reagent/catalyst;	97.3%

nitrobenzene (98-95-3) + aniline (62-53-3) → Phenazin (92-82-0) + p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6) + N-methylaniline (100-61-8) + Azobenzene (1227476-15-4)

Conditions	Yield
tetramethyl ammoniumhydroxide In water at 70 - 75℃; under 54.7555 Torr; for 3.5h;	A 1% B 87.9% C 6.9% D 1% E 6%

nitrobenzene (98-95-3) + aniline (62-53-3) → Phenazin (92-82-0) + p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6) + Azobenzene (1227476-15-4)

Conditions	Yield
betaine; tetramethyl ammoniumhydroxide In water at 70 - 75℃; under 54.7555 Torr; for 3.5h;	A 0.7% B 86.9% C 8.5% D 3.7%
potassium hydroxide; dibenzo-18-crown-6; betaine at 80℃; under 54.7555 Torr; for 6h;	A 1.3% B 65% C 13.2% D 15.7%
potassium hydroxide; betaine In water; isopropyl alcohol at 80℃; under 760.051 Torr; for 6h;	A 1.3% B 65.8% C 7.1% D 17.2%

nitrobenzene (98-95-3) + aniline (62-53-3) → p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6)

Conditions	Yield
Stage #1: aniline With potassium hydroxide at 60℃; under 45.0045 Torr; for 3h; Stage #2: nitrobenzene at 60℃;	A 76% B 20%
With sodium hydroxide; tetramethyl ammoniumhydroxide; tetramethylammonium carbonate In ethanol at 75℃; for 5h; Product distribution / selectivity;
With sodium hydroxide; tetramethyl ammoniumhydroxide; water at 75℃; under 60.006 Torr; Conversion of starting material;

nitrobenzene (98-95-3) + aniline (62-53-3) → Phenazin (92-82-0) + p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6) + Azobenzene (1227476-15-4) + 4-(Phenylazo)diphenylamine (101-75-7)

Conditions	Yield
potassium hydroxide; betaine In methanol; water at 40 - 80℃; under 30.003 - 150.015 Torr; for 6h;	A 1.2% B 73.5% C 13.5% D 9.6% E 0.17%
potassium hydroxide; betaine In methanol	A 1.1% B 58.6% C 12.8% D 13.2% E 0.2%
potassium hydroxide; betaine In water at 80℃; under 19.502 - 397.54 Torr; for 5h;	A 1.25 %Chromat. B 35.7 %Chromat. C 17.8 %Chromat. D 10.9 %Chromat. E 0.12 %Chromat.

nitrobenzene (98-95-3) + Acetanilid (103-84-4) → p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6) + Azobenzene (1227476-15-4)

Conditions	Yield
With sodium hydroxide In N,N,N,N,N,N-hexamethylphosphoric triamide at 80℃; for 5h;	A 62% B 10% C 10%
With sodium hydroxide In dimethyl sulfoxide at 80℃; for 5h; Mechanism; other solvent, other temperature;	A 60% B 10% C 10%
With sodium hydroxide In dimethyl sulfoxide at 80℃; for 5h;	A 60% B 10% C 10%
With sodium hydroxide In dimethyl sulfoxide at 130℃; for 5h;	A 30% B 10% C 30%

nitrobenzene (98-95-3) + bis(diphenyl)urea (102-07-8) → p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6) + Azobenzene (1227476-15-4) + azoxybenzene (495-48-7)

Conditions	Yield
With sodium hydroxide; tetramethyl ammoniumhydroxide In water at 80℃; under 50 - 90 Torr; for 3h; Product distribution / selectivity;	A 6% B 52% C 9% D 8%
With potassium hydroxide; tetramethyl ammoniumhydroxide In water at 80℃; under 50 - 90 Torr; for 3h; Product distribution / selectivity;	A 3% B 38% C 3% D 10%
Stage #1: nitrobenzene; bis(diphenyl)urea With sodium hydroxide; tetramethyl ammoniumhydroxide In water at 80℃; under 50 - 90 Torr; for 3h; Stage #2: With acetic acid In water; ethyl acetate Product distribution / selectivity;	A 6 %Chromat. B 52 - 85 %Chromat. C 9 - 10 %Chromat. D 8 - 17 %Chromat.
Stage #1: nitrobenzene; bis(diphenyl)urea With potassium hydroxide; tetramethyl ammoniumhydroxide In water at 80℃; under 50 - 90 Torr; for 3h; Stage #2: With acetic acid In water; ethyl acetate Product distribution / selectivity;	A 3 %Chromat. B 38 %Chromat. C 3 %Chromat. D 10 %Chromat.

nitrobenzene (98-95-3) + bis(diphenyl)urea (102-07-8) → p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6) + azoxybenzene (495-48-7)

Conditions	Yield
With tetramethyl ammoniumhydroxide In water; dimethyl sulfoxide at 80℃; under 760 Torr; for 3h; Product distribution / selectivity;	A 4% B 50% C 15%
Stage #1: nitrobenzene; bis(diphenyl)urea With tetramethyl ammoniumhydroxide In water; dimethyl sulfoxide at 80℃; under 760 Torr; for 3h; Stage #2: With acetic acid In water; dimethyl sulfoxide; ethyl acetate Product distribution / selectivity;	A 4 %Chromat. B 50 %Chromat. C 15 %Chromat.

nitrobenzene (98-95-3) + aniline (62-53-3) → p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6) + Azobenzene (1227476-15-4) + 4-(Phenylazo)diphenylamine (101-75-7)

Conditions	Yield
sodium hydroxide; betaine In methanol at 70℃; for 5h;	A 26.3% B 16.8% C 40.8% D 5.1%

nitrobenzene (98-95-3) + bis(diphenyl)urea (102-07-8) → Phenazin (92-82-0) + p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6) + Azobenzene (1227476-15-4) + azoxybenzene (495-48-7)

Conditions	Yield
With tetramethyl ammoniumhydroxide In water at 70 - 100℃; under 50 - 90 Torr; for 3h; Product distribution / selectivity;	A 3% B 8% C 37% D 4% E 12%
Stage #1: nitrobenzene; bis(diphenyl)urea With tetramethyl ammoniumhydroxide In water at 70 - 100℃; under 50 - 760 Torr; for 3h; Stage #2: With acetic acid In water; ethyl acetate Product distribution / selectivity;	A 0 - 8 %Chromat. B 3 - 9 %Chromat. C 29 - 90 %Chromat. D 0 - 10 %Chromat. E 0 - 27 %Chromat.

nitrobenzene (98-95-3) + aniline (62-53-3) → p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6) + Azobenzene (1227476-15-4)

Conditions	Yield
potassium hydroxide; betaine at 70℃;	A 36% B 16.3% C 13.8%
potassium hydroxide; betaine In methanol at 50 - 55℃; under 39.0039 Torr; for 4.5h;	A 18.2 %Chromat. B 10.0 %Chromat. C 8.5 %Chromat.
lithium hydroxide; betaine at 70℃;	A 0.15% B 0.34% C 0.24%

nitrobenzene (98-95-3) + bis(diphenyl)urea (102-07-8) → Phenazin (92-82-0) + p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6)

Conditions	Yield
With tetramethyl ammoniumhydroxide In water; toluene at 80℃; under 300 Torr; for 3h; Product distribution / selectivity;	A 2% B 9% C 35%
Stage #1: nitrobenzene; bis(diphenyl)urea With tetramethyl ammoniumhydroxide In water; toluene at 80℃; under 300 - 760 Torr; for 3h; Stage #2: With acetic acid In water; ethyl acetate; toluene Product distribution / selectivity;	A 0 - 2 %Chromat. B 7 - 9 %Chromat. C 10 - 35 %Chromat.

nitrobenzene (98-95-3) + bis(diphenyl)urea (102-07-8) → p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6)

Conditions	Yield
With tetramethyl ammoniumhydroxide In water at 80℃; under 760 Torr; for 3h; Product distribution / selectivity;	A 3% B 29%
With tetramethyl ammoniumhydroxide In water; toluene at 80℃; under 760 Torr; for 3h; Product distribution / selectivity;	A 7% B 10%
With tetramethyl ammoniumhydroxide In tetrahydrofuran; water at 80℃; under 760 Torr; for 3h; Product distribution / selectivity;	A 3% B 9%
Stage #1: nitrobenzene; bis(diphenyl)urea With tetramethyl ammoniumhydroxide In tetrahydrofuran; water at 80℃; under 760 Torr; for 3h; Stage #2: With acetic acid In tetrahydrofuran; water; ethyl acetate Product distribution / selectivity;	A 3 %Chromat. B 9 %Chromat.

nitrobenzene (98-95-3) + bis(diphenyl)urea (102-07-8) → Phenazin (92-82-0) + p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6) + azoxybenzene (495-48-7)

Conditions	Yield
With tetramethyl ammoniumhydroxide In water; benzene at 80℃; under 760 Torr; for 3h; Product distribution / selectivity;	A 2% B 10% C 24% D 5%
Stage #1: nitrobenzene; bis(diphenyl)urea With tetramethyl ammoniumhydroxide In water; benzene at 80℃; under 760 Torr; for 3h; Stage #2: With acetic acid In water; ethyl acetate; benzene Product distribution / selectivity;	A 2 %Chromat. B 10 %Chromat. C 24 %Chromat. D 5 %Chromat.

N-phenylquinone diimine (35548-96-0) → p-nitrosodiphenylamine (156-10-5)

Conditions	Yield
With hydroxylamine hydrochloride

nitrobenzene (98-95-3) + aniline (62-53-3) → p-nitrosodiphenylamine (156-10-5)

Conditions	Yield
With sodium hydroxide at 120 - 125℃;

diphenylamine (122-39-4) → p-nitrosodiphenylamine (156-10-5)

Conditions	Yield
With hydrogenchloride; methanol anschliessend Behandeln mit Natriumnitrit;
With hydrogenchloride; methanol; diethyl ether anschliessend Behandeln mit N-Nitroso-N-methyl-anilin in Aether;
With sulfuric acid; sodium nitrite

N-nitrosodiphenylamine (382165-80-2) → p-nitrosodiphenylamine (156-10-5)

Conditions	Yield
With hydrogenchloride In methanol at 21℃; Rate constant; Mechanism;
With hydrogenchloride; ethanol Entsteht das salzsaure Salz;
With hydrogenchloride; ethanol man loest das sich ausscheidende salzsaure Salz in Natronlauge und behandelt der filtrierten Loesung mit CO2;

aniline (62-53-3) → p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6) + trans-azobenzene (17082-12-1) + 4-(Phenylazo)diphenylamine (101-75-7) + N-phenylphenylene-1,4-diamine (101-54-2)

Conditions	Yield
With dihydrogen peroxide In dimethyl sulfoxide for 24h; Product distribution; also N-methylaniline;	A 3.1 mmol B 19.7 mmol C 63 mmol D 1.1 mmol E 3.3 mmol

p-nitrosophenol (104-91-6) + aniline (62-53-3) → p-nitrosodiphenylamine (156-10-5)

Conditions	Yield
(i) MeOH, TsOH, (ii) /BRN= 605631/, aq. HCl; Multistep reaction;

1-ethoxy-4-nitrosobenzene (3420-97-1) + aniline (62-53-3) → p-nitrosodiphenylamine (156-10-5)

Conditions	Yield
With sulfuric acid

hydrogenchloride (7647-01-0) + diethyl ether (60-29-7) + ethanol (64-17-5) + N-methyl-N-nitrosoaniline (614-00-6) + diphenylamine (122-39-4) → p-nitrosodiphenylamine (156-10-5)

hydrogenchloride (7647-01-0) + N-nitrosodiphenylamine (382165-80-2) → p-nitrosodiphenylamine (156-10-5)

nitrobenzene (98-95-3) + aniline (62-53-3) + sodium hydroxide → Phenazin (92-82-0) + Phenazin-mono-N-Oxyd (304-81-4) + p-nitrosodiphenylamine (156-10-5) + Azobenzene (1227476-15-4)

N-phenylquinone diimine (35548-96-0) + hydroxylamine hydrochloride → p-nitrosodiphenylamine (156-10-5)

hydrogenchloride (7647-01-0) + nitroso-(4-nitroso-phenyl)-phenyl-amine (13057-33-5) → p-nitrosodiphenylamine (156-10-5)

phenyl-bis-[4-(N-phenyl-hydrazino)-phenyl]-methane (857816-19-4) + acetic acid (64-19-7) + potassium nitrite → p-nitrosodiphenylamine (156-10-5)

hydrogenchloride (7647-01-0) + benzenediazo-(4-anilino-phenyl-hydroxylamide) → p-nitrosodiphenylamine (156-10-5) + benzene (71-43-2) + nitrogen

Phenazin (92-82-0) + p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6) + Azobenzene (1227476-15-4) → N-phenylphenylene-1,4-diamine (101-54-2)

Conditions	Yield
With hydrogen; nickel In methanol; water at 180℃; under 37503.8 Torr; for 0.116667h;	99.1%

p-nitrosodiphenylamine (156-10-5) + acetic anhydride (108-24-7) → N-{4[(acetyloxy)imino]-2,5-cyclohexadien-1-ylidene}aniline (18734-95-7)

Conditions	Yield
With pyridine In toluene at 5 - 20℃; for 2h;	96%

D-glucose (50-99-7) + p-nitrosodiphenylamine (156-10-5) → N-phenylphenylene-1,4-diamine (101-54-2)

Conditions	Yield
With sodium hydroxide In water	92%
With sodium hydroxide In water	70%

carbon disulfide (75-15-0) + p-nitrosodiphenylamine (156-10-5) + 4-ntrophenyl(phenyl)amine (836-30-6) + N-phenylphenylene-1,4-diamine (101-54-2) → 6-(anilino)benzothiazole-2(3H)-thione

Conditions	Yield
With sulfur at 250℃; under 60006 Torr; for 4h;	88%

1,3,5-trichloro-2,4,6-triazine (108-77-0) + p-nitrosodiphenylamine (156-10-5) → 2,4,6-tris(N-phenyl-p-benzoquinonediiminoxy)-1,3,5-trazine

Conditions	Yield
With sodium hydroxide In acetonitrile at 5 - 20℃; for 2h;	83.7%

p-nitrosodiphenylamine (156-10-5) + 4-bromo-3-methyl-1-phenylpyrazol-5-one (41927-23-5) → C22H18N4O2 (76369-65-8)

Conditions	Yield
In ethanol for 8h; Ambient temperature;	72%

3-amino-2-methyl-4-oxoquinazoline (1898-06-2) + p-nitrosodiphenylamine (156-10-5) → 2-Methyl-3-(4-phenylamino-phenyl-diazenyl)-3H-quinazolin-4-one (124414-14-8)

Conditions	Yield
With sodium acetate; acetic acid Heating;	70%

p-nitrosodiphenylamine (156-10-5) + 3-Amino-2-(n-butyl)quinazolin-4(3H)-one (120107-46-2) → 2-Butyl-3-(4-phenylamino-phenyl-diazenyl)-3H-quinazolin-4-one (124414-15-9)

Conditions	Yield
With sodium acetate; acetic acid Heating;	70%

p-nitrosodiphenylamine (156-10-5) + 3-amino-2-phenylquinazolin-4(3H)-one (1904-60-5) → 2-Phenyl-3-(4-phenylamino-phenyl-diazenyl)-3H-quinazolin-4-one (124414-16-0)

Conditions	Yield
With sodium acetate; acetic acid Heating;	65%

p-nitrosodiphenylamine (156-10-5) + edaravone (89-25-8) → 3-methyl-1-phenyl-4-(p-phenylamino)phenylimino-2-pyrazolin-5-one (50818-01-4)

Conditions	Yield
at 110℃; for 0.333333h;	46%

p-nitrosodiphenylamine (156-10-5) + N1,N3,N5-triphenylbenzene-1,3,5-triamine (102664-66-4) → 10-phenyl-6,8-bis(phenylamino)-2,10-dihydrophenazin-2-one (1636889-27-4)

Conditions	Yield
With hydrogenchloride In ethanol; water for 3h;	18%

p-nitrosodiphenylamine (156-10-5) + N1,N3,N5-triphenylbenzene-1,3,5-triamine (102664-66-4) → 10-phenyl-6,8-bis(phenylamino)-2,10-dihydrophenazin-2-one (1636889-27-4) + 1,3,7-tris(phenylamino)-5-phenylphenazinium sulfate

Conditions	Yield
With hydrogenchloride In ethanol; water	A 18% B 11%

5-methyl-benzo[b]thiophen-3-ol (65520-23-2) + p-nitrosodiphenylamine (156-10-5) → 2-(4-anilino-phenylimino)-5-methyl-benzo[b]thiophen-3-one

p-nitrosodiphenylamine (156-10-5) + 2,3-dichloro-1,4-benzoquinone (5145-42-6) → 5,6-dichloro-cyclohex-5-ene-1,2,3,4-tetraone-2,3-bis-[N-(4-anilino-phenyl)-oxime ]

Conditions	Yield
With ethanol

Upstream product

• 98-95-3 nitrobenzene 
• 62-53-3 aniline 
• 103-84-4 Acetanilid 
• 104-91-6 p-nitrosophenol 
• 3420-97-1 1-ethoxy-4-nitrosobenzene 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 64-17-5 ethanol 
• 614-00-6 N-methyl-N-nitrosoaniline 
• 122-39-4 diphenylamine 
• 382165-80-2 N-nitrosodiphenylamine 
• 35548-96-0 N-phenylquinone diimine 
• 13057-33-5 nitroso-(4-nitroso-phenyl)-phenyl-amine 
• 857816-19-4 phenyl-bis-[4-(N-phenyl-hydrazino)-phenyl]-methane 

Downstream Products

• 124414-14-8 2-Methyl-3-(4-phenylamino-phenyl-diazenyl)-3H-quinazolin-4-one 
• 50818-01-4 3-methyl-1-phenyl-4-(p-phenylamino)phenylimino-2-pyrazolin-5-one 
• 101-54-2 N-phenylphenylene-1,4-diamine 
• 105-11-3 p-benzoquinone dioxime 
• 24495-33-8 4-azidodiphenylamine 
• 637-62-7 p-benzoquinone oxime 
• 62-53-3 aniline 
• 4477-28-5 diphenylamine-4-diazonium hydrosulfate 
• 18734-93-5 N-{4[(benzoyloxy)imino]-2,5-cyclohexadien-1-ylidene}aniline 
• 118572-16-0 dichloro bis(p-nitroso diphenyl amine) palladium (II) 
• 1323355-65-2 C₂₇H₃₁N₂O₂ 
• 74-31-7 N,N'-diphenyl-1,4-phenylenediamine 
• 13057-33-5 nitroso-(4-nitroso-phenyl)-phenyl-amine 
• 100143-35-9 (4-anilino-phenyl)-amidosulfuric acid 

Related news

Reduction of 4-NITROSODIPHENYLAMINE (cas 156-10-5) with Sodium Hydroxy- and Aminoalkanesulfinates09/29/2019

The kinetics of reduction of 4-nitrosodiphenylamine with sodium alkanesulfinates were studied, and the reaction mechanism was suggested.detailed

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The invention relates to a synthesis method of p-nitrosodiphenylamine, in particular to a new process for preparing p-nitrosodiphenylamine by reacting N-carbanilide with nitrobenzene in the presence of proper alkali and a solvent. According to the invention, N-carbanilide with excellent reactivity and selectivity is adopted to react with nitrobenzene, and cheap alkali metal, alkaline earth metal and a polar organic solvent are adopted. And the method has the advantages of simple process, no by-product, high yield, no corrosive wastewater and environmental pollution reduction. And no chlorine-containing wastewater is generated, so that factors for corroding equipment can be eliminated.

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A novel protocol for efficient coupling of nitrobenzene and aniline in poly(ethylene glycol) medium in the presence of KOH giving diphenylamine derivatives has been developed, to enable the exclusion of the toxic tetramethylammonium hydroxide catalyst commonly used in the rubber antidegradant industry.

PROCESS FOR THE PREPARATION OF 4-AMINODIPHENYLAMINE PRECURSORS

Process for the preparation of 4-aminodiphenylamine precursors by reacting aniline and nitrobenzene in the presence of water and a base, with controlled amount of water with respect to the base, characterised in that the mole ratio of water to the dosed base, obtained after extraction of organic impurities by an aromatic solvent of an aqueous phase from hydrogenation of a condensation mixture, is between 3.99 and 3:1 at the start of the coupling reaction, and between 0.40 and 0.59:1 at the end of the coupling reaction, and the end of the coupling reaction is indicated by full conversion of nitrobenzene or by achieving the maximum content 2 wt. % of the initial amount of nitrobenzene in the reaction mixture. The ingredients are continuously fed into reactor cascades in the required ratio to the condensation process, the mole ratio of aniline to nitrobenzene is between 1 :1 and 10:1, and hydrogenation of the condensation product in the presence of a hydrogenation catalyst and added water is followed by separation of the hydrogenation catalyst, and an organic phase, containing 4-aminodiphenylamine, is separated from the aqueous phase, containing the released base.