15729-76-7

Usage

Uses

Used in Flavor and Fragrance Industry:
2,5-Diethylthiazole is used as a flavoring agent for its nutty, corn-like aroma, adding depth and complexity to various food products and beverages.
Used in Organic Synthesis:
2,5-Diethylthiazole is used as a key building block in the synthesis of more complex organic molecules, contributing to the development of new compounds with potential applications in various industries, such as pharmaceuticals, materials science, and agrochemicals.

InChI:InChI=1/C7H11NS/c1-3-6-5-8-7(4-2)9-6/h5H,3-4H2,1-2H3

Upstream product

• 108284-83-9 2,5-diethyl-2,5-dihydro-thiazole 
• 24764-97-4 2-bromobutanal 
• 79-05-0 Propionamid 
• 631-58-3 thiopropanamide 
• 1838-73-9 (+/-)-2-Methylheptan-4-ol 
• 541-46-8 isobutylamide 
• 927-77-5 n-propylmagnesium bromide 
• 81925-81-7 5-methyl 2-hepten-4-one 
• 671795-46-3 sec-butylmagnesium bromide 
• 123-72-8 butyraldehyde 
• 425-75-2 trifluoromethanesulfonic acid ethyl ester 
• 67-64-1 acetone 
• 74-88-4 methyl iodide 
• 123-19-3 4-heptanone 

Relevant academic research and scientific papers

Synthesis of 2,4-diacetylthiazole and 2,5-diacetylthiazole

Compounds 2,4-diacetylthiazole 5 and 2,5-diacetylthiazole 6, of interest for their flavour and aroma properties, have been prepared for the first time by tetrabromination and silver nitrate treatment of the corresponding diethylthiazoles.

Synthesis of β-Methyl Alcohols: Influence of Alkyl Chain Length on Diastereoselectivity and New Attractants of Rhynchophorus ferrugineus

The diastereoselectivity of adducts in the addition reaction via the Felkin-Anh model is affected significantly by the steric effect of bulky groups. However, the influence of steric alkyl chain length has not been studied for the diastereoselectivity. In this work, we present a new strategy for the racemic synthesis of β-methyl alcohols to obtain various diastereomer ratios using the Felkin-Anh model. The addition of alkyl Grignard reagents to α-methyl aldehydes afforded diastereomer ratios of threo/erythro ≈ 2:1, while the reduction in structurally related ketones using LiAlH4 afforded ratios of threo/erythro ≈ 1:1. The experimental data showed no effect of alkyl chain length on either side on the stereoselectivity of adducts. All synthesized analogues were evaluated for attractiveness to Rhynchophorus ferrugineus weevils in the field. Five novel derivatives, including two alcohols and three ketones, were found to attract weevils in the field trials. Among them, 3-methyldecan-4-one (5b) and 4-methyldecan-5-ol (11a) were found to be the most attractive to the insects.

α-Methylation of ketones via manganese-enolates: Absence of undesired polyalkylation

The transmetalation of ketone lithium-enolates using MnBr2 generates manganese-enolates which react with CH3I to provide α-methylated ketones with essentially no undesired polyalkylated byproducts.