An efficient synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI): An enhanced and simplified analog of the CC-1065 and duocarmycin alkylation subunits

Article abstract of DOI:10.1021/jo00110a034

An efficient synthesis of 4, the immediate precursor to N-BOC-CBI and related analogs of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa[c]benz[c]indol-4-one alkylation subunit, is described based on a Tempo trap of a 5-exo-trig aryl radical-alken