An efficient synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI): An enhanced and simplified analog of the CC-1065 and duocarmycin alkylation subunits

DOI: 10.1021/jo00110a034

Source and publish data:

Journal of Organic Chemistry p. 1271 - 1275 (1995)

Update date:2022-07-30

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Authors:

Boger Boger

McKie McKie

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Article abstract of DOI:10.1021/jo00110a034

An efficient synthesis of 4, the immediate precursor to N-BOC-CBI and related analogs of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa[c]benz[c]indol-4-one alkylation subunit, is described based on a Tempo trap of a 5-exo-trig aryl radical-alken

Full text of DOI:10.1021/jo00110a034

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