17059-51-7

Usage

Uses

Used in Pharmaceutical Industry:
6-methylbenzofuran is used as a key intermediate in the synthesis of pharmaceuticals for its versatile chemical structure and potential therapeutic properties, including antioxidant and anti-inflammatory effects.
Used in Perfumery:
6-methylbenzofuran is used as a fragrance ingredient in perfumes due to its pleasant aroma, enhancing the scent profiles of various fragrances.
Used in Flavoring Agents:
6-methylbenzofuran is used as a flavoring agent in the food and beverage industry to impart unique and desirable flavors, enhancing the taste and aroma of products.
Used in Antioxidant Applications:
6-methylbenzofuran is used as an antioxidant in various applications, including food preservation and health supplements, due to its ability to neutralize free radicals and protect against oxidative stress.
Used in Anti-inflammatory Applications:
6-methylbenzofuran is used in anti-inflammatory formulations for its potential to reduce inflammation and alleviate symptoms associated with inflammatory conditions.

InChI:InChI=1/C9H8O/c1-7-2-3-8-4-5-10-9(8)6-7/h2-6H,1H3

Upstream product

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• 6921-64-8 4'-hydroxy-2'-methylacetophenone 
• 144219-74-9 2‐bromo‐1‐(2‐hydroxy‐4‐methylphenyl)ethanone 
• 702-69-2 7-methyl-1,4-dioxa-spiro[4.5]decan-8-one 
• 51673-84-8 dimethoxyacetaldehyde 
• 89897-04-1 4-hydroxy-3-methylcyclohexan-1-one 
• 22061-78-5 2-bromo-3-methylphenol 
• 20895-41-4 6-methylbenzofuran-3(2H)-one 
• 1643-15-8 2-(m-tolyloxy)acetic acid 
• 40926-72-5 2-(m-tolyloxy)acetyl chloride 
• 108-39-4 3-methyl-phenol 

Relevant academic research and scientific papers

TRANSCRIPTION FACTOR BRN2 INHIBITORY COMPOUNDS AS THERAPEUTICS AND METHODS FOR THEIR USE

The invention provides a variety of compounds having the structure of Formula I and uses of such compounds for treatment of various indications, including cancer as well as methods of treatment involving such compounds are also provided. The uses of the compounds may specifically include: bladder cancer, cholangiocarcinoma; colorectal cancer; diffuse large B-cell lymphoma (DLBC); liver cancer; ovarian cancer; thymoma; thyroid cancer; clear cell renal cell carcinoma (CCRCC); chromophobe renal cell carcinoma (ChRCC); prostate cancer; breast cancer; uterine cancer; pancreatic cancer; cervical cancer; uveal melanoma; acute myeloid leukemia (AML); head and neck cancer; small cell lung cancer (SCLC); lung adenocarcinoma sarcoma; mesothelioma; adenoid cystic carcinoma (ACC), sarcoma; testicular germ cell cancer; uterine cancer; pheochromocytoma and paraganglioma (PCPG); melanoma; glioma; glioblastoma multiforme; T-cell Acute Lymphoblastic Leukemia; T-cell Lympohoma, medulloblastoma; and neuroblastoma.

A vicarious, one-pot synthesis of benzo- and naphthofurans: Applications to the syntheses of stereumene B and paeoveitols

An interesting albeit unexpected deviation during attempted Tanabe γ-lactone annulation on 4-hydroxycyclohexanones has led to a general, one-pot synthesis of benzofurans and naphtho[2,3–b]furans from readily assembled precursors. The utility of this adaptable methodology has been demonstrated through concise syntheses of natural products, stereumene B, paeoveitol D and (±)-paeoveitol.

OXADIAZINE COMPOUNDS AND METHODS OF USE THEREOF

The present disclosure relates to oxadiazine compounds, pharmaceutical compositions comprising an effective amount of an oxadiazine compound and methods for using an oxadiazine compound in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of an oxadiazine compound.

Total synthesis of the 2-arylbenzo[b]furan-containing natural products from Artocarpus

In this study, 2-arylbenzo[b]furan-containing derivatives moracin C (1) and moracin M (4), the natural products from Artocarpus, have been synthesized in highest overall yield to date (1, 7 steps with an overall yield of 41.9%; 4, 6 steps with an overall yield of 56.3%), and we also report the first total synthesis of artoindonesianin B-1 (2), another member of this family, in the same route (8 steps with an overall yield of 11.3%). This discovery provides a concise route for preparing enough amounts of 1, 2, and 4 as well as 2-arylbenzo[b]furan-containing natural product-like analogs (71-74) to explore the biological potential.

Zeolite-catalyzed synthesis of 2,3-unsubstituted benzo[b]furans via the intramolecular cyclization of 2-aryloxyacetaldehyde acetals

An efficient and environmentally benign heterogeneous catalytic process for the synthesis of 2,3-unsubstituted benzo[b]furans has been established via the intramolecular cyclization of 2-aryloxyacetaldehyde acetals. By utilizing tin-exchanged H-β zeolite (Sn-β) as catalyst, a wide range of functionalized 2,3-unsubstituted benzo[b]furans could be prepared in good to excellent yields. The Sn-β zeolite catalyst also exhibited excellent shape selectivity on the cyclization of meta-substituted 2-aryloxyacetaldehyde acetals, and 6-substituted isomers were preferably formed up to 97% regio-selectivity. Moreover, Sn-β zeolite could be easily recovered and reused without any noticeable activity loss.

Gold catalysis: benzanellation versus alkylidenecyclopentenone synthesis

A series of different furan-yn-ols were prepared by a three-step sequence. Their reaction with Gagosz's catalyst Ph3PAuNTf2 depends strongly on the substitution pattern of the substrate and the quality of the leaving group. Benzofurans, alkylidenecyclopentenones or Meyer-Schuster type products can be obtained. Improving the leaving group quality leads to the preferred formation of benzofurans.

2-Nitrofurans as dienophiles in Diels-Alder reactions

α-Nitrofuran derivatives are studied in Diels-Alder reactions under thermal conditions. In contrast to α-acylfurans, they proved to be efficient dienophiles.