17351-95-0

Basic information

• Product Name: 2-Phenoxy-1,1,1-trifluoroethane
• Synonyms: 2,2,2-Trifluoroethoxybenzene;2-Phenoxy-1,1,1-trifluoroethane
• CAS NO: 17351-95-0
• Molecular Formula: C₈H₇F₃O
• Molecular Weight: 176.1357896
• Mol File: 17351-95-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 150.3°C at 760 mmHg
• Flash Point: 50.7°C
• Appearance: /
• Density: 1.203g/cm³
• Vapor Pressure: 4.92mmHg at 25°C
• Refractive Index: 1.432
• CAS DataBase Reference: 2-Phenoxy-1,1,1-trifluoroethane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenoxy-1,1,1-trifluoroethane(17351-95-0)
• EPA Substance Registry System: 2-Phenoxy-1,1,1-trifluoroethane(17351-95-0)

Safety Data

• Hazardous Substances Data: 17351-95-0(Hazardous Substances Data)

Usage

General Description

2-Phenoxy-1,1,1-trifluoroethane is a chemical compound with the molecular formula C8H7F3O. It is a phenoxyethane derivative, containing a phenoxy group attached to a 1,1,1-trifluoroethane moiety. This chemical is commonly used as a solvent and as a propellant in aerosol products. It has a high boiling point and low flammability, making it suitable for use in various industrial and consumer applications. 2-Phenoxy-1,1,1-trifluoroethane is also used as a refrigerant and in the production of air conditioning systems. However, it is important to handle this compound with care as it can be harmful if inhaled or ingested, and it may also have environmental and health hazards associated with its use.

InChI:InChI=1/C8H7F3O/c9-8(10,11)6-12-7-4-2-1-3-5-7/h1-5H,6H2

Upstream product

• 108-86-1 bromobenzene 
• 75-89-8 2,2,2-trifluoroethanol 
• 733-53-9 p-methoxyphenyl(phenyl)iodonium tetrafluoroborate 
• 1065-05-0 hexakis(2,2,2-trifluoroethoxy)cyclotriphosphazene 
• 139-02-6 sodium phenoxide 
• 420-87-1 sodium 2,2,2-trifluoroethanolate 
• 80134-77-6 4-methoxyphenyl (phenyl)iodonium phosphorus hexafluoride 
• 108-90-7 chlorobenzene 
• 71-43-2 benzene 
• 762-72-1 allyl-trimethyl-silane 
• 591-50-4 iodobenzene 
• 25236-64-0 2,2,2-trifluoroethyl methanesulfonate 
• 108-95-2 phenol 
• 855719-15-2 trifluoroethanol 

Downstream Products

• 151868-17-6 2-fluoro-1-methoxy-3-(trifluoromethyl)benzene 
• 36724-25-1 3-propylbenzofuran 

Relevant articles and documents

Ligand-free Ullmann-type C-heteroatom couplings under practical conditions

A new practical ligand-free protocol for copper-catalyzed C-heteroatom cross-coupling reactions (Ullmann-type) is described. The use of dimethyl sulfoxide (DMSO) as the solvent overcomes the need to use organic auxiliary ligands; thus, DMSO is revealed as a nontoxic and superior solvent for Ullmann-type coupling reactions. This method allows the arylation of a wide range of amides, alcohols, and amines under practical conditions with bromobenzene and iodobenzene derivatives and will likely find direct application in current organic synthesis. The competitive reactivity among different functional groups is reported and rationalized, and the possibility to achieve selective arylation reactions is demonstrated. Copyright

Fluoride-promoted ligand exchange in diaryliodonium salts

Diaryliodonium salts are shown to undergo rapid, fluoride-promoted aryl exchange reactions at room temperature in acetonitrile. Aryl exchange is shown to be exquisitely sensitive to the concentration of fluoride ion in solution; fast exchange is observed as the fluoride concentration approaches a stoichiometric amount at 50 mM substrate concentration. The reaction is slowed, but not halted if benzene is the solvent, indicating that free fluoride ion or a four-coordinate anionic I(III) species may be responsible for the exchange. The fluoride-promoted aryl exchange reaction is general and allows direct measurement of the relative stabilities of diaryliodonium salts featuring different aryl substituents. The aryl exchange reaction may be of practical use for the preparation of hitherto inaccessible diaryliodonium salts, thus it also has implications for labeling radiotracers for molecular imaging with 18F-fluoride (t1/2 = 109.7 min).

Facile access to fluorinated aryl and vinyl ethers through copper-catalysed reaction of fluoro alcohols

Fluorinated alcohols react with aryl and vinyl halides by copper-catalysed cross-coupling reactions to afford the corresponding ethers. With trifluoroethanol (TFE) the reaction proceeds with both iodides and bromides and a wide range of aromatic substituents are tolerated. When higher fluorinated homologues such as C7P15CH2OH were used, the corresponding products were obtained in good yields, thus of-fering an interesting entry to fluorous tagging.