19299-40-2

Upstream product

• 110-82-7 cyclohexane 
• 624-90-8 Methanesulfonyl azide 
• 7285-32-7 2H-thiete 1,1-dioxide 
• 108-91-8 cyclohexylamine 
• 3144-09-0 methanesulfonamide 
• 124-63-0 methanesulfonyl chloride 
• 133323-03-2 Diethyl 2-(methylsulfonylamino)phenyl phosphate 
• 96626-22-1 (E)-N-cyclohexyl-N-2-phenylethenylmethanesulphonamide 
• 110-83-8 cyclohexene 
• 96626-18-5 N-cyclohexyl-N-2-hydroxy-2-phenylethylmethanesulphonamide 
• 6912-38-5 N-(2-hydroxyphenyl)methanesulphonamide 
• 133323-01-0 2-Chloro-2,3-dihydro-3-(methylsulfonyl)-1,3,2λ⁵-benzoxazaphosphole 2-oxide 
• 133323-00-9 2,3-Dihydro-2-methoxy-3-(methylsulfonyl)-1,3,2-benzoxazaphosphole 
• 133323-02-1 2-Ethoxy-2,3-dihydro-3-(methylsulfonyl)-1,3,2λ⁵-benzoxazaphosphole 2-oxide 

Downstream Products

• 96626-18-5 N-cyclohexyl-N-2-hydroxy-2-phenylethylmethanesulphonamide 
• 84200-45-3 N-cyclohexyl-N-decyl-mesylamide 
• 84200-43-1 N-cyclohexyl-N-dodecyl-mesylamide 
• 204857-37-4 C₁₂H₂₃NO₄S 
• 740801-29-0 N-cyclohexyl-N-pivaloyloxymethyl methanesulfonamide 
• 740801-34-7 N-{1-[(cyclohexyl-methanesulfonyl-amino)-methyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide 
• 6490-87-5 N-dodecylcyclohexanamine 
• 30249-30-0 N-decylcyclohexanamine 
• 95287-15-3 cyclohexyl-hexadecyl-amine 
• 84200-53-3 N-Cyclohexyl-N-decyl-formamide 
• 84200-52-2 N-Cyclohexyl-N-decyl-acetamide 
• 84200-51-1 N-Cyclohexyl-N-dodecyl-formamide 
• 84200-50-0 N-cyclohexyl,-N-dodecylacetamide 
• 84200-55-5 N-Cyclohexyl-N-hexadecyl-formamide 

Relevant academic research and scientific papers

Phosphine/Photoredox Catalyzed Anti-Markovnikov Hydroamination of Olefins with Primary Sulfonamides via α-Scission from Phosphoranyl Radicals

New strategies to access radicals from common feedstock chemicals hold the potential to broadly impact synthetic chemistry. We report a dual phosphine and photoredox catalytic system that enables direct formation of sulfonamidyl radicals from primary sulf

Sulfonamide Synthesis through Electrochemical Oxidative Coupling of Amines and Thiols

Sulfonamides are key motifs in pharmaceuticals and agrochemicals, spurring the continuous development of novel and efficient synthetic methods to access these functional groups. Herein, we report an environmentally benign electrochemical method which enables the oxidative coupling between thiols and amines, two readily available and inexpensive commodity chemicals. The transformation is completely driven by electricity, does not require any sacrificial reagent or additional catalysts and can be carried out in only 5 min. Hydrogen is formed as a benign byproduct at the counter electrode. Owing to the mild reaction conditions, the reaction displays a broad substrate scope and functional group compatibility.

Sulfonamide Synthesis through Electrochemical Oxidative Coupling of Amines and Thiols

Sulfonamides are key motifs in pharmaceuticals and agrochemicals, spurring the continuous development of novel and efficient synthetic methods to access these functional groups. Herein, we report an environmentally benign electrochemical method which enables the oxidative coupling between thiols and amines, two readily available and inexpensive commodity chemicals. The transformation is completely driven by electricity, does not require any sacrificial reagent or additional catalysts and can be carried out in only 5 min. Hydrogen is formed as a benign byproduct at the counter electrode. Owing to the mild reaction conditions, the reaction displays a broad substrate scope and functional group compatibility.

1,3,4-OXADIAZOLE SULFONAMIDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to novel compounds represented by the formula I having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. (I) The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases.

Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents

A series of novel carbazole-containing sulfonamides and sulfamides were synthesized. A structure-activity relationship study of these compounds led to the identification of potent cryptochrome modulators. Based on the results of efficacy studies in diet-induced obese (DIO) mice, and the desired pharmacokinetic parameters, compound 41 was selected for further profiling.

Palladium-Catalyzed cascade sp2 c?H bond functionalizations allowing one-Pot access to 4?Aryl-1,2,3,4-tetrahydroquinolines from n?Allyl?N?arylsulfonamides

We have developed a palladium-catalyzed cascade reaction allowing an efficient synthesis of 4-aryl-1,2,3,4-tetrahydroquinolines from N-allyl-N-arylsulfonamides and benzenesulfonyl chlorides. In this transformation, two C(sp2)?C(sp3) bonds were formed via activation of C(sp2)?H bonds. The reaction proceeds using the easily accessible catalyst PdCl2, with Li2CO3 as inexpensive base and CuBr as additive, and tolerates a wide variety of substituents on both reaction partners.

Metal-free reductive cleavage of C-N and S-N bonds by photoactivated electron transfer from a neutral organic donor

A photoactivated neutral organic super electron donor cleaves challenging arenesulfonamides derived from dialkylamines at room temperature. It also cleaves a)ArC-NR and b)ArN-C bonds. This study also highlights the assistance given to these cleavage reactions by the groups attached to N in (a) and to C in (b), by lowering LUMO energies and by stabilizing the products of fragmentation. Radical fragmentations: Electron transfer from the photoactivated neutral electron donor 1 delivers high yields of S-N and C-N cleavage products for a range of nitrogen-containing species. These reactions proceed at room temperature and under mild reaction conditions in the absence of any metal reagents. DMF=N,N-dimethylformamide, Ts=4-toluenesulfonyl.

Transition metal-free intermolecular a-C-H amination of ethers at room temperature

We describe a new method for the intermolecular amination of the α-C-H bonds of ethers. A hypervalent iodine reagent was used as oxidant to enable the amination of cyclic and acyclic alkyl ethers with a wide range of amides, imides, and amines. The amination occurred at room temperature and without a transition metal catalyst. The method could be used to synthesize the anti-cancer prodrug Tegafur and its analogues.

Stereoselective direct reductive amination of ketones with electron-deficient amines using Re2O7/NaPF6 catalyst

The first example of direct reductive amination (DRA) of ketones with electron-deficient amines (EDA) such as Cbz-, Boc-, EtOCO-, Fmoc-, Bz-, ArSO2-, etc. protected amines have been achieved using catalytic Re2O7/NaPF6. Excellent chemoselectivities as well as diastereoselectivity (for 2-alkyl cyclohexanones) were obtained. The Royal Society of Chemistry 2013.

Convenient synthesis of primary sulfonamides

An efficient protocol for a one-pot synthesis of mono-sulfonamides has been developed. It features utilization of excess of sulfonylating agent followed by base mediated recovery of the primary sulfonamide.