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19482-11-2

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19482-11-2 Usage

Description

4-CHLORO-4'-METHYL-1,1'-BIPHENYL, with the molecular formula C13H11Cl, is a chlorinated biphenyl derivative featuring a methyl substituent on one of its phenyl rings. This chemical compound is utilized in a variety of industrial and research applications, such as a starting material for synthesizing other organic compounds and as a reference standard in analytical chemistry. Due to its toxic nature and potential harm to human health and the environment, careful handling and usage are imperative.

Uses

Used in Chemical Synthesis:
4-CHLORO-4'-METHYL-1,1'-BIPHENYL is used as a starting material in the synthesis of other organic compounds, contributing to the creation of a diverse range of chemical products.
Used in Analytical Chemistry:
In the field of analytical chemistry, 4-CHLORO-4'-METHYL-1,1'-BIPHENYL serves as a reference standard, aiding in the calibration and validation of analytical methods and instruments.
Used in Research Applications:
4-CHLORO-4'-METHYL-1,1'-BIPHENYL is employed in research settings to study the properties and reactions of chlorinated biphenyls and their derivatives, furthering scientific understanding in organic chemistry.
Used in Industrial Applications:
4-CHLORO-4'-METHYL-1,1'-BIPHENYL finds use in various industrial processes, where its unique structural features and reactivity are leveraged to produce specific chemical products or intermediates.
It is crucial to note that due to the toxic and potentially harmful nature of 4-CHLORO-4'-METHYL-1,1'-BIPHENYL, strict safety measures and environmental considerations must be adhered to during its use in any application.

Check Digit Verification of cas no

The CAS Registry Mumber 19482-11-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,4,8 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 19482-11:
(7*1)+(6*9)+(5*4)+(4*8)+(3*2)+(2*1)+(1*1)=122
122 % 10 = 2
So 19482-11-2 is a valid CAS Registry Number.

19482-11-2Relevant articles and documents

Transformation of Trifluorotoluenes Triggered by Titanium(IV) Chloride-Catalyzed Hydrodefluorination using Hydrosilanes

Yamada, Takayuki,Saito, Kodai,Akiyama, Takahiko

, p. 62 - 66 (2016)

The titanium tetrachloride-catalyzed hydrodefluorination reaction of trifluorotoluene derivatives was developed using triethylsilane as the reducing agent. The reaction produced various toluene derivatives with high chemoselectivities by means of readily accessible reagents. This hydrodefluorination process was extended to the intramolecular Friedel-Crafts benzylation reaction, furnishing polycyclic aromatics of various ring sizes in good yields.

Pillar[5]arene-based N-heterocyclic carbene ligand for Pd-catalysed Suzuki reaction

Xiao, Xue-Dong,Liu, Jia-Qi,Bai, Ya-Li,Wang, Rui-Hua,Wang, Jun-Wen

, p. 29 - 36 (2017)

A pillar[5]arene-based N-heterocyclic carbene ligand was prepared by reaction of bromoethoxy pillar[5]arene with excess 1-methylimidazole at 130?°C in the absence of solvent and used as a catalyst for the Suzuki coupling reaction. Excellent yields were obtained when the Suzuki reactions were carried out under ambient atmosphere in ethanol, employing 0.2?mol% ligand, 1?mol% PdCl2(CH3CN)2 and 1.5?mmol of K2CO3. The novel pillar[5]arene-based imidazolium salt is a promising material for the construction of highly active supramolecular catalytic systems.

Engineering of highly active Au/Pd supported on hydrogenated urchin-like yolk@shell TiO2 for visible light photocatalytic Suzuki coupling

Rohani, Sahar,Ziarati, Abolfazl,Ziarani, Ghodsi Mohammadi,Badiei, Alireza,Burgi, Thomas

, p. 3820 - 3827 (2019)

Efficient smart photocatalysts and their surface engineering are necessary for the effective conversion of light energy into chemical energy in photocatalyzed organic reactions. Herein, we designed a hydrogenated urchin-like yolk@shell TiO2 structure decorated with Au and Pd nanoparticles (HUY@S-TOH@AuPd) as a robust photocatalyst for C-C coupling reactions. The resulting architecture exhibits considerable photocatalytic performance in Suzuki coupling reactions under visible light irradiation with a turnover frequency (TOF) value as high as 7095 h-1. The beauty of this engineered structure lies on the following four points: (I) the urchin-like structure provided a large accessible surface area for high light harvesting as well as high noble metal anchoring; (II) the yolk@shell mesoporous architecture improved the absorption of light by multiple scattering; (III) the presence of Ti3+ species on the surface of TiO2 decreased the band gap of the structure to the visible region; (IV) the enriched electron density of Pd through the injection of hot electrons from Au as well as the flow of electrons from the titanium dioxide semiconductor to the metals accelerated the rate-determining step. The merging of bimetallic plasmonic nanoparticles and urchin like yolk-shell hydrogenated titanium dioxide architecture can open an avenue for designing photocatalysts with high stability and promising activity as well as high direct harvesting of visible light for a broad range of photocatalytic organic reactions.

Mesoporous palladium-copper ferrites as highly efficient and magnetically separable catalysts for Suzuki coupling reaction

Tong, Jinhui,Su, Lingdi,Bo, Lili,Cai, Xiaodong,Zhang, Qianping,Wang, Qizhao

, p. 240 - 246 (2016)

Mesoporous Cu-Pd ferrites were prepared by using MCM-41 and SBA-15 mesoporous molecular sieves as hard templates and well characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), ICP-atomic emission spectroscopy, N2 adsorption-desorption and X-ray photoelectric spectroscopy (XPS). Compared with samples prepared by the sol-gel auto-combustion methods, the as-prepared mesoporous ferrites have shown uniform pore size and much higher specific surface areas. The samples showed a remarkably high activity in connection with the Suzuki coupling reaction, especially Cu0.99Pd0.01Fe2O4 prepared by using MCM-41 as template obtained an excellent TOF as high as 36.9 × 103 h-1 and no obvious decrease in the activity was observed after ten consecutive runs.

Palladium(II) thiosemicarbazone-catalyzed Suzuki-Miyaura cross-coupling reactions of aryl halides

Pandiarajan, Devaraj,Ramesh, Rengan,Liu, Yu,Suresh, Rajamanickam

, p. 33 - 37 (2013)

A new air-and moisture-stable palladium(II) complex bearing pyridoxal thiosemicarbazone ligand has been synthesized. The synthesized complex was characterized by analytical and spectral methods. The molecular structure of the complex was confirmed by X-ray diffraction method. The palladium(II) complex was used as potential catalyst for Suzuki-Miyaura coupling reaction of several aryl halides under optimized conditions.

Room-temperature Suzuki-Miyaura reaction catalyzed by palladium nanoparticles in lactate-anion ionic liquid

Wang, Furong,Tang, Sisi,Ma, Hao,Wang, Lefu,Li, Xuehui,Yin, Biaolin

, p. 1225 - 1232 (2014)

A palladium nanoparticle catalyst (PdNPs[Bmim]Lac) has been prepared by a simple, mild and efficient chemical approach using 1-butyl-3-methylimidazolium lactate ([Bmim]Lac) ionic liquid) as a stabilizer. This catalyst exhibits excellent activity, stability, recyclability and simple manipulation in Suzuki-Miyaura reactions at room temperature in air.

DNA as a bioligand supported on magnetite for grafting palladium nanoparticles for cross-coupling reaction

Kandathil, Vishal,Kempasiddaiah, Manjunatha,Nataraj, Sanna Kotrappanavar,Patil, Siddappa A.,Somappa, Sasidhar Balappa

, (2020)

The utilization of deoxyribonucleic acid (DNA) in nanotechnology is a promising area of research wherein the distinct properties of DNA are exploited for the design and development of new materials and applications. The biodegradability and natural profusion of DNA makes it highly suitable for use in various fields. In this report, we have treated DNA as a bioligand, supported on functionalized magnetite for the grafting of palladium (Pd) nanoparticles to make Pd-DNA bio-nanocatalyst. The Pd-DNA was subjected to Fourier-transform infrared spectroscopy, field-emission scanning electron microscopy, transmission electron microscopy, X-ray powder diffraction, Brunauer–Emmett–Teller, energy dispersive X-ray spectroscopy, vibrating sample magnetometry, X-ray photoelectron spectroscopy, and inductively coupled plasma optical emission spectrometry analysis. The prepared Pd-DNA was found to be highly efficient in catalyzing Suzuki–Miyaura cross-coupling reaction with excellent yields when compared with commercially available palladium-based catalysts. Also, the Pd-DNA could be easily recovered from the reaction mass using an external magnet and recycled up to six times without substantial loss of activity. Furthermore, Felbinac, a non-inflammatory drug, was synthesized in quantitative yields using the Pd-DNA bio-nanocatalyst.

Palladium nanoparticles supported on functional ionic liquid modified magnetic nanoparticles as recyclable catalyst for room temperature Suzuki reaction

Wang, Jiayi,Xu, Beiling,Sun, Haiyang,Song, Gonghua

, p. 238 - 241 (2013)

Palladium nanoparticles were successfully immobilized on amine functionalized ionic liquid modified magnetic nanoparticles leading to a magnetically recoverable Pd catalyst, which exhibits high catalytic activity in the Suzuki coupling reaction at room temperature. The catalyst can be separated from the reaction mixture by applying a permanent magnet externally and can be reused for several times without significant loss of activity.

Synthesis, characterization and evaluation of bulky bis(pyrazolyl)palladium complexes in Suzuki-Miyaura cross-coupling reactions

Ocansey, Edward,Darkwa, James,Makhubela, Banothile C. E.

, p. 13826 - 13834 (2018)

Pyrazole-containing compounds have been used in recent times as ligands to stabilize metal complexes used as pre-catalysts in cross-coupling reactions. With various substituents at various positions in the pyrazole ring, the overall electrophilic and steric properties of the metal complexes can be fine-tuned. Herein, we report the synthesis of bulky pyrazole-based ligands by condensation of methyl 4-(bromomethyl)benzoate or benzyl bromide with various substituted pyrazole compounds. These ligands were utilised in the synthesis of bis(pyrazolyl)palladium(ii) complexes. The complexes' catalytic activity in Suzuki-Miyaura cross-coupling reactions was evaluated. Phenyl bearing pre-catalyst 7, at a catalyst loading of 0.33 mol%, successfully converted 98% of bromobenzene and phenylboronic acid to biphenyl in 4 h at 140 °C, while the tertiary butyl bearing pre-catalyst 8 converted up to 81% of the same substrates to biphenyl. An increase in conversion was seen for all pre-catalysts when an electron-withdrawing substituent was present on the aryl halide substrate, and the opposite was observed when the electron-withdrawing group was present on the phenyl boronic acid.

Bimetallic nano alloy architecture on a special polymer: Ni or Cu merged with Pd for the promotion of the Mizoroki–Heck reaction and the Suzuki–Miyaura coupling

Patil, Vijay P,Kashid, Abhijit A,Solanki, Bhanupratap S,Kharul, Ulhas K,Iyer, Suresh

, (2021/02/12)

Abstract: Novel Ni-Pd and Cu-Pd bimetallic nano alloys was designed and heterogenized on the highly robust ABPBI [poly(2,5-benzimidazole)] polymer in high yields using NaBH4 as reducing agent. These were versatile ligand free catalysts for the Mizoroki–Heck reaction and Suzuki–Miyaura coupling. The bimetallic Ni-Pd-ABPBI catalyst for the Mizoroki–Heck reaction of 4-iodo anisole could be recycled 5 times with high yields. Aryl bromides could also be activated for the Mizoroki–Heck reaction using Cu-Pd-ABPBI NP catalysts, with moderate yields. Graphic abstract: Synopsis Novel bimetallic Ni-Pd and Cu-Pd nano alloys, heterogenized on the robust ABPBI [poly(2,5-benzimidazole)] polymer using NaBH4 as reducing agent, is described. These were versatile ligand free, noble metal conservative catalysts, for the Mizoroki–Heck reaction and the Suzuki–Miyaura coupling. Aryl bromides were activated for the Mizoroki–Heck reaction using the Cu-Pd-ABPBI catalyst.[Figure not available: see fulltext.]

Anchored Pd(0) Nanoparticles on Synthetic Talc for the Synthesis of Biaryls and a Precursor of Angiotensin II Inhibitors

Dos Santos, Beatriz F.,Da Silva, Beatriz A. L.,De Oliveira, Aline R.,Sarragiotto, Maria H.,Domingues, Nelson Luís C.

, p. 933 - 942 (2020/12/28)

The palladium-catalyzed Suzuki-Miyaura cross-coupling reaction is one of the most important and efficient reactions to prepare a variety of organic compounds, including biaryls. Despite the overwhelming number of reports related to this topic, some methodological difficulties persist in terms of catalyst handling, recovery, and reuse, as well as the reaction media. This work reports the rational design of new, efficient, cost-effective, and reusable palladium catalysts supported on synthetic talc for the Suzuki-Miyaura reaction. From the results, key points were identified: both designed catalysts accelerated the reaction in EtOH and an open-flask setup, affording moderate to excellent yields within a short time (e.g., 30 min) even for deactivated aryl halides; the protocol can be applied to a great number of both cross-coupling partners, showing an excellent functional group tolerance; the catalysts can be recovered and reused without significant loss of activity. This protocol was used for the synthesis of a precursor of angiotensin II inhibitors such as valsartan, losartan, irbesartan, and telmisartan.

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