20294-48-8

Basic information

• Product Name: Phenol, 2,4-diiodo-6-nitro-
• CAS NO: 20294-48-8
• Molecular Formula: C6H3I2NO3
• Molecular Weight: 390.904
• Mol File: 20294-48-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Phenol, 2,4-diiodo-6-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2,4-diiodo-6-nitro-(20294-48-8)
• EPA Substance Registry System: Phenol, 2,4-diiodo-6-nitro-(20294-48-8)

Safety Data

• Hazardous Substances Data: 20294-48-8(Hazardous Substances Data)

Upstream product

• 21784-73-6 4-iodo-2-nitrophenol 
• 88-75-5 2-hydroxynitrobenzene 
• 540-38-5 p-Iodophenol 
• 108-95-2 phenol 
• 2012-29-5 2,4-diiodophenol 
• 7697-37-2 nitric acid 
• 533-58-4 2-Iodophenol 
• 616-82-0 3-nitro-4-hydroxybenzoic acid 
• 85-38-1 3-nitrosalicylic acid 
• 7080-50-4 chloramine T trihydrate 
• 64-19-7 acetic acid 
• 7732-18-5 water 
• 64-17-5 ethanol 
• 7553-56-2 iodine 

Downstream Products

• 677004-02-3 2,4-diiodo-6-nitroanisole 

Relevant articles and documents

Iodination of industrially important aromatic compounds with aqueous potassium triiodide

A new reagent system consisting of aqueous KI3in AcOH and NaIO4as oxidant has been found to be effective in iodinating a variety of commercially important aromatic substrates under ambient conditions. The presence of Na2SO3enhances the yield and the product purity. The procedure ensures high yields (72–98%) at room temperature in a short reaction time. A remarkable feature of this system is that even acidsensitive functionalities like anilines can be iodinated quantitatively.

A green reagent for the iodination of phenols

A new reagent (I2/NaNO2) for the iodination of the aromatic ring of phenols has been discovered. The reaction proceeds at room temperature in 1.5-6 hours. In the presence of this reagent, iodinated compounds are regioselectively formed in significant yields from the corresponding substrates. Georg Thieme Verlag Stuttgart.

Nitrophenol derivatives oxidized by cerium(IV) ammonium nitrate (CAN) and their cytotoxicity

Oxidation of a series of phenols with cerium(IV) ammonium nitrate (CAN) in acetonitrile undermild conditions yields the mixture of corresponding nitrophenols. In the cases of methylphenols and hydroxy-carboxylic acids, the steric effect may reduce the nitration reaction. Compounds 3 a and 4b showed selective activities to Hep 3B and Hep G2 cancer cell lines, respectively. Compound 2c showed selective activities to Hep G2 and MDA-MB-231 cancer cell lines. Further more, com pound 10b showed selective activities to Hep G2, Hep 3B, MCF-7 and MDA-MB-231 cancer cell lines.