20907-13-5

Upstream product

• 13694-98-9 2-ethoxy-3,3-dimethyl-2-phenyl-oxirane 
• 16282-15-8 (1-ethoxy-2-methyl-1-propenyl)benzene 
• 100-52-7 benzaldehyde 
• 67-64-1 acetone 
• 67-63-0 isopropyl alcohol 
• 75-16-1 methylmagnesium bromide 
• 65868-37-3 ethyl 2-oxo-3-chloropropionate 
• 774-40-3 hydroxy-phenyl-acetic acid ethyl ester 
• 611-71-2 MANDELIC ACID 
• 23022-83-5 1-bromo-1-phenyl-2-propanone 
• 148204-86-8 (tert-butyldimethylsilanyloxy)phenylacetic acid methyl ester 
• 4358-87-6 (RS)-methyl mandelate 
• 103-79-7 1-phenyl-acetone 
• 10409-54-8 2-bromo-2-methyl-1-phenyl-propan-1-one 

Downstream Products

• 10152-58-6 2,2-dimethyl-3-phenyloxirane 
• 3805-10-5 2,2-(dimethyl)-2-phenylacetaldehyde 
• 98369-75-6 1,2-diphenyl-2-methylpropane-1-ol 
• 769-59-5 3-phenyl-butan-2-one 
• 100-52-7 benzaldehyde 
• 67-64-1 acetone 
• 1628436-91-8 1-(allyloxy)-2-methyl-1-phenylpropan-2-ol 
• 1616561-81-9 2-ethyl-4,4-dimethyl-5-phenyl-1,3-dioxolane 
• 7473-98-5 2-hydroxy-2-methylpropiophenone 
• 13740-70-0 2-methyl-1,2-diphenyl-propan-1-one 
• 65-85-0 benzoic acid 
• 59189-28-5 1,4-Diphenyl-3-hydroxy-4-methylpentan-1-on 
• 4564-84-5 Benzoic acid 2-hydroxy-2-methyl-1-phenyl-propyl ester 
• 102168-38-7 2,2,5,5-tetramethyl-3,6-diphenyl-[1,4]dioxane 

Relevant academic research and scientific papers

Formal synthesis of P-chiral [16O,17O,18O]phosphoenol pyruvates by means of the α-hydroxyphosphonate-phosphate rearrangement

Transesterification of tris(hexafluoroisopropyl) phosphite with racemic 3-methyl-1-phenyl-butane-1,3-diol gave two isomeric hexafluoroisopropyl-substituted 1,2,3-dioxaphosphinanes. These cyclic phosphites were hydrolyzed rapidly and enantioselectively by water catalyzed by HCl. The respective metalated H-phosphonates were added to ethyl 3-chloropyruvate and underwent a stereospecific α-hydroxyphosphonate-phosphate rearrangement to protected phosphoenol pyruvates. This sequence with oxygen isotope-labeled enantiomers represents an alternative approach to P-chiral [16O,17O,18O]phosphoenol pyruvates.

Half-sandwich rhodium complexes with phenylene-based SCS ligands: Synthesis, characterization and catalytic activities for transfer hydrogenation of ketones

A series of half-sandwich rhodium complexes with tridentate phenylene-based bis(thione) (SCS) ligand have been synthesized and characterized. Both half-sandwich rhodium complexes and phenylene-based bis(thione) compounds were fully characterized by 1H and 13C NMR spectra, mass spectrometry and single-crystal X-ray diffraction method. The catalytic activities of half-sandwich rhodium complexes toward the transfer hydrogenation of ketones to their corresponding alcohols were explored using 2-propanol as hydrogen source and solvent. And the half-sandwich rhodium complexes exhibited high catalytic activity for transfer hydrogenation of ketones with a broad functional group tolerance.

Postsynthetic Modification of Half-Sandwich Ruthenium Complexes by Mechanochemical Synthesis

A mild and environmentally friendly method to synthesize half-sandwich ruthenium complexes through the Wittig reaction between an aldehyde-tagged half-sandwich ruthenium complex and phosphorus ylide mechanochemically is reported herein. The mechanochemical synthesis of valuable half-sandwich ruthenium complexes resulted in a fast reaction, good yield with simple workup, and the avoidance of harsh reaction conditions and organic solvents. The synthesized half-sandwich ruthenium complexes exhibited high catalytic activity for transfer hydrogenation of ketones using 2-propanol as the hydrogen source and solvent. Density functional theory was carried out to propose a mechanism for the transfer hydrogenation process. The modeling suggests the importance of the labile p-cymene ligand in modulating the reactivity of the catalyst.

Preparation of Organic Nitrates from Aryldiazoacetates and Fe(NO3)3·9H2O

A thermal protocol is reported for the formal insertion of nitric acid into aryldiazoacetates using Fe(NO3)3·9H2O. This strategy is mild and high yielding and allows the preparation of a large variety of members of an unprecedented family of organic nitrates. The nitrate group can be also readily transformed into other functional groups and heterocyclic moieties and can possibly allow new biological explorations of untapped potential associated with their NO-releasing ability.

A Well-Defined Osmium-Cupin Complex: Hyperstable Artificial Osmium Peroxygenase

Thermally stable TM1459 cupin superfamily protein from Thermotoga maritima was repurposed as an osmium (Os) peroxygenase by metal-substitution strategy employing the metal-binding promiscuity. This novel artificial metalloenzyme bears a datively bound Os ion supported by the 4-histidine motif. The well-defined Os center is responsible for not only the catalytic activity but also the thermodynamic stability of the protein folding, leading to the robust biocatalyst (Tm ≈ 120 °C). The spectroscopic analysis and atomic resolution X-ray crystal structures of Os-bound TM1459 revealed two types of donor sets to Os center with octahedral coordination geometry. One includes trans-dioxide, OH, and mer-three histidine imidazoles (O3N3 donor set), whereas another one has four histidine imidazoles plus OH and water molecule in a cis position (O2N4 donor set). The Os-bound TM1459 having the latter donor set (O2N4 donor set) was evaluated as a peroxygenase, which was able to catalyze cis-dihydroxylation of several alkenes efficiently. With the low catalyst loading (0.01% mol), up to 9100 turnover number was achieved for the dihydroxylation of 2-methoxy-6-vinyl-naphthalene (50 mM) using an equivalent of H2O2 as oxidant at 70 °C for 12 h. When octene isomers were dihydroxylated in a preparative scale for 5 h (2% mol cat.), the terminal alkene octene isomers was converted to the corresponding diols in a higher yield as compared with the internal alkenes. The result indicates that the protein scaffold can control the regioselectivity by the steric hindrance. This protein scaffold enhances the efficiency of the reaction by suppressing disproportionation of H2O2 on Os reaction center. Moreover, upon a simple site-directed mutagenesis, the catalytic activity was enhanced by about 3-fold, indicating that Os-TM1459 is evolvable nascent osmium peroxygenase.

Amine Catalysis for the Organocatalytic Diboration of Challenging Alkenes

The generation of in situ sp2–sp3diboron adducts has revolutionised the synthesis of organoboranes. Organocatalytic diboration reactions have represented a milestone in terms of unpredictable reactivity of these adducts. However, current methodologies have limitations in terms of substrate scope, selectivity and functional group tolerance. Here a new methodology based on the use of simple amines as catalyst is reported. This methodology provides a completely selective transformation overcoming current substrate scope and functional/protecting group limitations. Mechanistic studies have been included in this report.

ERK INHIBITORS

The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are ERK2 inhibitors. The invention also provides a method of inhibiting ERK2 in a patient in need of such treatment comprising administering to said patient an effective amount of at least one compound of Formula (I). The invention also provides a method for treating cancer in a patient in need of such treatment, said method comprising administering to said patient an effective amount of at least one compound of Formula (I).

Synthesis of oxacyclic scaffolds via dual ruthenium hydride/Bronsted acid-catalyzed isomerization/cyclization of allylic ethers

A ruthenium hydride/Bronsted acid-catalyzed tandem sequence is reported for the synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]indoles (THPIs) and related oxacyclic scaffolds. The process was designed on the premise that readily available allylic ethers would undergo sequential isomerization, first to enol ethers (Ru catalysis), then to oxocarbenium ions (Bronsted acid catalysis) amenable to endo cyclization with tethered nucleophiles. This methodology provides not only an attractive alternative to the traditional oxa-Pictet-Spengler reaction for the synthesis of THPIs, but also convenient access to THPI congeners and other important oxacycles such as acetals.

Magnetically recoverable osmium catalysts with osmium-diolate esters for dihydroxylation of olefins

We prepared magnetically recoverable osmium catalysts with stable osmium-diolate esters and applied them to the dihydroxylation of olefins. By employing 2 mol% of the magnetic osmium catalyst, the dihydroxylation reaction proceeded smoothly to provide the corresponding vicinal diol with a low level of osmium leaching. After completion of the dihydroxylation, the osmium catalyst was readily recovered by use of an external magnet and was recycled up to five times. Georg Thieme Verlag Stuttgart . New York.

Homogeneous dihydroxylation of olefins catalyzed by OsO4 2- immobilized on a dendritic backbone with a tertiary nitrogen at its core position

OsO42- immobilized on a poly(benzyl ether) dendrimer with a tertiary nitrogen at its core position efficiently catalyzed the homogeneous dihydroxylation of olefins with a low level of osmium leaching. The dendritic osmium catalyst could be applied to the wide range of olefins. Furthermore, the dendritic osmium catalyst was recovered by reprecipitation and then reused up to five times.