2161-87-7

Usage

Uses

Used in Organic Synthesis:
2,4,6-Triacetylphloroglucinol is used as a compound in organic synthesis for the creation of various complex organic molecules.
Used in Pharmaceutical Industry:
2,4,6-Triacetylphloroglucinol is used as a precursor in the synthesis of trinuclear vanadium Schiff base complexes, copper complexes, and anthelmintics, contributing to the development of pharmaceutical agents.
Used in Biocontrol of Plant Diseases:
Although weakly active, 2,4,6-Triacetylphloroglucinol and related metabolites are important in the biocontrol of plant diseases by some Pseudomonas strains, playing a role in dereplication to eliminate leads with high amounts of weakly potent actives.

Preparation

Obtained by Friedel–Crafts acylation of phloroglucinol, ? with acetic anhydride in the presence of boron trifluoride in acetic acid at r.t. (60%) ; ? with acetyl chloride in the presence of aluminium chloride in ethyl ether at r.t. for 6 days (17%); ? with acetyl chloride and acetic acid in the presence of ferric chloride in ethyl acetate.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 60-29-7 diethyl ether 
• 504-64-3 carbon suboxide 
• 2999-40-8 1,3,5-triacetoxybenzene 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 108-73-6 3,5-dihydroxyphenol 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 7705-08-0 iron(III) chloride 
• 141-78-6 ethyl acetate 
• 75-36-5 acetyl chloride 
• 7446-70-0 aluminium trichloride 
• 98-95-3 nitrobenzene 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 108-73-6 3,5-dihydroxyphenol 
• 64-19-7 acetic acid 
• 1261061-33-9 2,4,6-triacetyl-1,3,5-tris(dimethylthiocarbamoyloxy)benzene 
• 862981-14-4 2,4,6-tris{1-[(2-(3,5-di-tert-butylsalicylaldimino)-2-methylpropyl)imino]ethyl}-1,3,5-trihydroxybenzene 
• 618382-31-3 2,4,6-tris(1-(2-salicylaldimino-2-methylpropylimino)-ethyl)-1,3,5-trihydroxybenzene 

Relevant academic research and scientific papers

Use of a hexasubstituted benzene scaffold in the development of multivalent HIV-1 integrase inhibitors

The highly directional hexasubstituted benzene moiety was used as the central scaffold to create new human immunodeficiency virus (HIV)-1 integrase inhibitors through the attachment of multiple active groups. A series of potential inhibitors having substi

Synthesis and amino acids complexation of tripodal hexasubstituted benzene chiral receptors

(Chemical Equation Presented). The parent 1,3,5-triacetyl-2,4,6-trihydroxybenzene was prepared in up to 91% yield using a one-pot, one step reaction catalyzed by aluminum chloride. Its alkylations with 1,5-dibromopentane generated a symmetric tripodal hex

Three-metal-center Schiff base-aluminium compound, preparation method, application and preparation method of polylactic acid

The invention provides a three-metal-center Schiff base-aluminium compound, which has a structure as shown in the formula (I). By using triacetyl-m-trihydroxybenzene as the core, a three-metal active center binding site is provided to form three-metal-cen

One pot synthesis and anticancer activity of dimeric phloroglucinols

A series of dimeric phloroglucinol compounds were synthesized in a single step using commercially available phloroglucinol and methanesulfonic acid. Based on the reported anticancer activity of plant derived dimeric phloroglucinols, these synthesized comp

Selective fries rearrangement catalyzed by zinc powder

Zinc powder in the presence of N,N-dimethylformamide efficiently catalyzes the selective Fries rearrangement of acetylated phenols under microwave heating or with conventional heating using an oil bath. In some cases different products were obtained using microwave heating and conventional heating. Selective migration of the acyl group has been noted with good yields.

Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibitors

A novel class of fluoro-substituted tris-chalcones derivatives (5a-5i) was synthesized from phloroglucinol and corresponding benzaldehydes. A three step synthesis method was followed for the production of these tris-chalcone compounds. The structures of t