22771-99-9

Basic information

• Product Name: 4-(4-Chlorophenylsulfonyl)Morpholine, 97%
• Synonyms: 4-(4-Chlorophenylsulfonyl)Morpholine, 97%
• CAS NO: 22771-99-9
• Molecular Formula: C₁₀H₁₂ClNO₃S
• Molecular Weight: 261.72518
• Mol File: 22771-99-9.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 400°Cat760mmHg
• Flash Point: 195.7°C
• Appearance: /
• Density: 1.393g/cm³
• Vapor Pressure: 1.31E-06mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 4-(4-Chlorophenylsulfonyl)Morpholine, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Chlorophenylsulfonyl)Morpholine, 97%(22771-99-9)
• EPA Substance Registry System: 4-(4-Chlorophenylsulfonyl)Morpholine, 97%(22771-99-9)

Safety Data

• Hazardous Substances Data: 22771-99-9(Hazardous Substances Data)

Usage

General Description

4-(4-Chlorophenylsulfonyl)Morpholine, 97% is a chemical compound with a molecular formula of C10H11ClNO3S and a molecular weight of 261.72 g/mol. It is a white to off-white crystalline solid with a purity of 97%, and is soluble in organic solvents such as methanol and ethanol. 4-(4-Chlorophenylsulfonyl)Morpholine, 97% is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is known for its ability to react with a variety of nucleophiles and electrophiles, and is often used as a reagent in organic synthesis. Additionally, 4-(4-Chlorophenylsulfonyl)Morpholine, 97% is also used as a crosslinking agent in the preparation of polymer materials.

InChI:InChI=1/C10H12ClNO3S/c11-9-1-3-10(4-2-9)16(13,14)12-5-7-15-8-6-12/h1-4H,5-8H2

Upstream product

• 4394-85-8 4-morpholinecarboxaldehyde 
• 106-54-7 p-Chlorothiophenol 
• 1828-66-6 morpholine-4-sulfonyl chloride 
• 1679-18-1 4-Chlorophenylboronic acid 
• 110-91-8 morpholine 
• 23328-69-0 4-chloromorpholine 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 1146-44-7 4,4'-dichlorophenyl thiosulfonate 
• 5138-90-9 sodium 4-chlorobenzenesulfonate 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 2751-25-9 p-chlorophenylsulfonyl hydrazide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 14752-66-0 sodium p-chlorobenzenesulphinate 

Relevant articles and documents

S(vi) in three-component sulfonamide synthesis: Use of sulfuric chloride as a linchpin in palladium-catalyzed Suzuki-Miyaura coupling

Sulfuric chloride is used as the source of the -SO2- group in a palladium-catalyzed three-component synthesis of sulfonamides. Suzuki-Miyaura coupling between the in situ generated sulfamoyl chlorides and boronic acids gives rise to diverse sulfonamides in moderate to high yields with excellent reaction selectivity. Although this transformation is not workable for primary amines or anilines, the results show high functional group tolerance. With the solving of the desulfonylation problem and utilization of cheap and easily accessible sulfuric chloride as the source of sulfur dioxide, redox-neutral three-component synthesis of sulfonamides is first achieved. This journal is

Efficient and Practical Synthesis of Sulfonamides Utilizing SO2 Gas Generated on Demand

A simple and practical protocol was developed for the synthesis of sulfonamides by reacting organometallic reagents with SO2 gas generated on demand. SO2 was generated from readily available reagents safely in a highly contained and controlled fashion. The protocol allows the synthesis of sulfonamides without using either atom-inefficient SO2 surrogates or a SO2 cylinder that requires stringent storage regulations in the laboratory. The protocol was successfully applied to the synthesis of sildenafil.

Cu-catalyzed aerobic oxidative synthesis of sulfonamides from sulfonyl hydrazides and amines

An environmentally friendly route for sulfonamides has been developed. The oxidative coupling of sulfonyl hydrazides and amines was catalyzed by CuBr2 to produce various sulfonamides with the water and nitrogen gas as byproducts. Preliminary experiments revealed that the sulfonyl radical is likely to be involved in the reaction mechanism.