28740-63-8Relevant articles and documents
Cu microcrystals garnished with copper nanoparticles catalyzed one-pot facile synthesis of novel 1,2,3-triazoles via click chemistry as antifungal agents
Kodasi, Barnabas,Joshi, Shrinivas D.,Kamble, Ravindra R.,Keri, Rangappa S.,Bayannavar, Praveen K.,Nesaragi, Aravind R.,Dixit, Shruti,Vootla, Shyam Kumar,Metre, Tukaram V.
, (2022/04/07)
A remarkable, efficacious, and environmental friendly one-pot procedure affianced for the synthesis of 1,2,3-triazoles by 1,3-dipolar cycloaddition of aromatic azides, terminal alkynes over Cu microcrystals (CuMCs) by click chemistry as subsequent way. The predominance of this method is green synthetic pathway, transient reaction times, facile workup, exceptional yields (87% to 90%) with excellent purity, regioselective single product formation, and eco-friendliness of the CuMCs catalyst. Docking studies manifested strong binding interactions with enzyme sterol 14-alpha-demethylase (PDB ID: 3KHM) with excellent C-score values. The antifungal screening of synthesized compounds revealed promising activity.
Click chemistry based regioselective one-pot synthesis of coumarin-3-yl-methyl-1,2,3-triazolyl-1,2,4-triazol-3(4H)-ones as newer potent antitubercular agents
Somagond, Shilpa M.,Kamble, Ravindra R.,Bayannavar, Praveen K.,Shaikh, Saba Kauser J.,Joshi, Shrinivas D.,Kumbar, Vijay M.,Nesaragi, Aravind R.,Kariduraganavar, Mahadevappa Y.
, (2019/08/12)
Coumarin-3-yl-methyl-1,2,3-triazolyl-1,2,4-triazol-3(4H)-ones (8k-z) were synthesized via copper(I)-catalyzed azide-alkyne cycloaddition click chemistry. The synthesized hybrid molecules were characterized by spectral studies. Compounds 8k-z were screened for their in vitro anti-TB activity by using the Microplate Alamar Blue assay and for cytotoxicity using the MTT assay. Some of the compounds were found to be most potent against the tested Mycobacterium tuberculosis H37Rv strain with a MIC of 1.60 μg/ml. Further, docking the compounds into the InhA binding pocket showed strong binding interactions and effective overall docking scores were recorded. The drug-likeness and toxicity studies were computed using Molinspiration and Protox, respectively.
One-pot multicomponent synthesis of novel thiazol-2-imines via microwave irradiation and their antifungal evaluation
Shaikh, Saba Kauser Jaweed,Kamble, Ravindra Ramappa,Somagond, Shilpa M.,Kamble, Atulkumar A.,Kumbar, Mahadev N.
supporting information, p. 2061 - 2073 (2018/07/21)
Microwave-assisted green approach is developed for an efficient synthesis of thiazol-2-imines under catalyst-free conditions. The desired products are formed by one-pot three-component reaction which is an improvised method for Hantzsch thiazole synthesis
