2345-56-4

Basic information

• Product Name: malonamic acid
• Synonyms: malonamic acid;3-Amino-3-oxopropionic acid;Malonamidic acid;3-amino-3-oxopropanoic acid(SALTDATA: FREE);3-amino-3-keto-propionic acid;Monoamide of a dicarboxylic acid;3-Oxo-3-aminopropionic acid
• CAS NO: 2345-56-4
• Molecular Formula: C₃H₅NO₃
• Molecular Weight: 103.0767
• EINECS: 219-069-5
• Mol File: 2345-56-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 121 °C
• Boiling Point: 424.4°Cat760mmHg
• Flash Point: 210.4°C
• Appearance: /
• Density: 1.402g/cm³
• Vapor Pressure: 2.17E-08mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: pK1:3.641(0) (25°C)
• CAS DataBase Reference: malonamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: malonamic acid(2345-56-4)
• EPA Substance Registry System: malonamic acid(2345-56-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 2345-56-4(Hazardous Substances Data)

Usage

General Description

Malonamic acid, also known as malonamidic acid, is a chemical compound with the formula C3H3NO3. It is a derivative of malonic acid and is commonly used in organic synthesis as a starting material for various compounds. Malonamic acid has two carboxylic acid groups and an amide group, making it a versatile building block for the synthesis of pharmaceuticals, agrochemicals, and materials. It is also used as a reagent in the preparation of other important compounds, such as 1,3-diketones and α,β-unsaturated carboxylic acids. Additionally, malonamic acid can be used as a corrosion inhibitor and as a component in metal complexes for catalytic purposes. Overall, malonamic acid plays a crucial role in the production of a wide range of chemical products.

InChI:InChI=1/C3H5NO3/c4-2(5)1-3(6)7/h1H2,(H2,4,5)(H,6,7)

Upstream product

• 141-82-2 malonic acid 
• 57-13-6 urea 
• 113-00-8 guanidine nitrate 
• 67-56-1 methanol 
• 78-93-3 butanone 
• 100-19-6 (4-nitrophenyl)ethanone 
• 98-86-2 acetophenone 
• 120-92-3 cyclopentanone 
• 100-52-7 benzaldehyde 
• 555-16-8 4-nitrobenzaldehdye 
• 99-61-6 3-nitro-benzaldehyde 
• 99-91-2 para-chloroacetophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 115122-63-9 2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carboxylic acid 
• 168003-23-4 [Ni(H₂NCOCH₂COO)2(H₂O)2] 
• 820-99-5 2-Hexeneamide 
• 60-35-5 acetamide 
• 124-38-9 carbon dioxide 
• 141-82-2 malonic acid 
• 110-14-5 butanediamide 
• 29122-75-6 (E)-3-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-acrylamide 
• 925-56-4 cis-3-cyano-acrylic acid methyl ester 
• 26294-98-4 2-pentenenitrile 
• 621-79-4 cinnamamide 
• 1202-41-1 (E)-3-(3,4-dihydroxyphenyl)acrylamide 
• 61892-67-9 4-methyl-pent-2-enoic acid amide 
• 15856-96-9 (E)-pent-2-enoylamide 

Relevant articles and documents

Hydrogen bond patterns in solid state carboxylic acids. Vibrational study of the hydrogen bond patterns in oxamic, malonamic and succinamic acid

The vibrational spectra of oxamic, malonamic and succinamic acid are reported.Although these molecules exhibit identical functional groups, their solid state hydrogen bond patterns can be divided in two different types, which can be clearly distinguished through the combination of infrared and Raman spectroscopy at variable temperatures and through the vibrational behaviour of the deuterated compounds.Oxamic acid behaves as a linear hydrogen bonded polymer with cyclic acid-acid and cyclic amide-amide dimers while the other discussed carboxylic acid derivatives exhibit a cyclic acid-amide hydrogen bond pattern.A model is proposed to investigate the peculiar vibrational behaviour of oxamic acid theoretically.Spectroscopic studies of the cyclic heterogenic acid-amide hydrogen bond pattern are studied for the first time.

Odorless thioacetalization reagent 2-[1,3] dithian-2-ylidene-3-oxo- butanamide and its chemoselectivity

2-[1,3]Dithian/dithiolan-2-ylidene-3-oxo-butanamide 2a/2b were synthesized and investigated in the thioacetalization reaction of aldehydes/ketones 3. The experiments revealed that 2a could be used as a nonthiolic, odorless 1,3-propanedithiol equivalent in the conversion of aldehydes/ketones into the corresponding dithianes 4, however, 2b was less effective. Moreover, the chemoselectivity of the thioacetalization of 3 in the presence of 2a is discussed.

Intramolecular Influence of a Carboxylic Function on Platinium Blue Synthesis. A systematic Study of Complexes Originating from Acid Amides

The use of acid amide as ligand for obtaining platinium blue has been investigated.While blue compounds are generally obtained by using the hydrolysis product of cis-dichlorodiammineplatinum(II) as platinum surce, with such ligands the reaction occurs very readily using potassium tetrachloroplatinate(II).The role of the carboxylic function which offers here a primary ligating site to platinum is evidenced.The compounds obtained have been characterized by UV-visible spectral measurments, Ce(IV) oxydative titration , ESR spectroscopy, and magnetic properties.Antitumoral activity toward leukemia L1210 and sarcoma 180 is reported for two of thesecompounds.As a first step for this antitumor study, these compounds have been found to be inactive toward Leukemia while they presnt intersting activity toward Sarcoma.