2345-56-4

Usage

Uses

Used in Organic Synthesis:
Malonamic acid is used as a starting material for the synthesis of various compounds due to its two carboxylic acid groups and an amide group, which provide a wide range of reactivity and functionalization options.
Used in Pharmaceutical Production:
Malonamic acid is used as a building block in the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Production:
Malonamic acid is utilized in the production of agrochemicals, such as pesticides and herbicides, due to its ability to form stable and effective compounds.
Used in Material Science:
Malonamic acid is employed in the synthesis of materials with specific properties, such as polymers and coatings, owing to its versatile chemical structure.
Used as a Reagent:
Malonamic acid is used as a reagent in the preparation of other important compounds, such as 1,3-diketones and α,β-unsaturated carboxylic acids, which are essential in various chemical processes.
Used as a Corrosion Inhibitor:
Malonamic acid is used as a corrosion inhibitor, protecting metals from degradation and extending their service life in various industrial applications.
Used in Metal Complexes for Catalysis:
Malonamic acid is incorporated into metal complexes for catalytic purposes, enhancing the efficiency of chemical reactions and contributing to green chemistry practices.

InChI:InChI=1/C3H5NO3/c4-2(5)1-3(6)7/h1H2,(H2,4,5)(H,6,7)

Upstream product

• 105-53-3 diethyl malonate 
• 15159-48-5 2,4-oxetanedione 
• 108-13-4 malonodiamide 
• 7597-56-0 ethyl malonamate 
• 98-01-1 furfural 
• 67-56-1 methanol 
• 98-03-3 thiophene-2-carbaldehyde 
• 119-61-9 benzophenone 
• 104-87-0 4-methyl-benzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 99-91-2 para-chloroacetophenone 
• 99-61-6 3-nitro-benzaldehyde 
• 555-16-8 4-nitrobenzaldehdye 
• 120-92-3 cyclopentanone 

Downstream Products

• 61892-67-9 4-methyl-pent-2-enoic acid amide 
• 15856-96-9 (E)-pent-2-enoylamide 
• 1202-41-1 (E)-3-(3,4-dihydroxyphenyl)acrylamide 
• 60-35-5 acetamide 
• 621-79-4 cinnamamide 
• 26294-98-4 2-pentenenitrile 
• 925-56-4 cis-3-cyano-acrylic acid methyl ester 
• 141-82-2 malonic acid 
• 124-38-9 carbon dioxide 
• 168003-23-4 [Ni(H₂NCOCH₂COO)2(H₂O)2] 
• 820-99-5 2-Hexeneamide 
• 110-14-5 butanediamide 
• 29122-75-6 (E)-3-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-acrylamide 
• 372-09-8 cyanoacetic acid 

Relevant academic research and scientific papers

Hydrogen bond patterns in solid state carboxylic acids. Vibrational study of the hydrogen bond patterns in oxamic, malonamic and succinamic acid

The vibrational spectra of oxamic, malonamic and succinamic acid are reported.Although these molecules exhibit identical functional groups, their solid state hydrogen bond patterns can be divided in two different types, which can be clearly distinguished through the combination of infrared and Raman spectroscopy at variable temperatures and through the vibrational behaviour of the deuterated compounds.Oxamic acid behaves as a linear hydrogen bonded polymer with cyclic acid-acid and cyclic amide-amide dimers while the other discussed carboxylic acid derivatives exhibit a cyclic acid-amide hydrogen bond pattern.A model is proposed to investigate the peculiar vibrational behaviour of oxamic acid theoretically.Spectroscopic studies of the cyclic heterogenic acid-amide hydrogen bond pattern are studied for the first time.

Prebiotic Origin of Pre-RNA Building Blocks in a Urea “Warm Little Pond” Scenario

Urea appears to be a key intermediate of important prebiotic synthetic pathways. Concentrated pools of urea likely existed on the surface of the early Earth, as urea is synthesized in significant quantities from hydrogen cyanide or cyanamide (widely accepted prebiotic molecules), it has extremely high water solubility, and it can concentrate to form eutectics from aqueous solutions. We propose a model for the origin of a variety of canonical and non-canonical nucleobases, including some known to form supramolecular assemblies that contain Watson-Crick-like base pairs.The dual nucleophilic-electrophilic character of urea makes it an ideal precursor for the formation of nitrogenous heterocycles. We propose a model for the origin of a variety of canonical and noncanonical nucleobases, including some known to form supramolecular assemblies that contain Watson-Crick-like base pairs. These reactions involve urea condensation with other prebiotic molecules (e. g., malonic acid) that could be driven by environmental cycles (e. g., freezing/thawing, drying/wetting). The resulting heterocycle assemblies are compatible with the formation of nucleosides and, possibly, the chemical evolution of molecular precursors to RNA. We show that urea eutectics at moderate temperature represent a robust prebiotic source of nitrogenous heterocycles. The simplicity of these pathways, and their independence from specific or rare geological events, support the idea of urea being of fundamental importance to the prebiotic chemistry that gave rise to life on Earth.

Odorless thioacetalization reagent 2-[1,3] dithian-2-ylidene-3-oxo- butanamide and its chemoselectivity

2-[1,3]Dithian/dithiolan-2-ylidene-3-oxo-butanamide 2a/2b were synthesized and investigated in the thioacetalization reaction of aldehydes/ketones 3. The experiments revealed that 2a could be used as a nonthiolic, odorless 1,3-propanedithiol equivalent in the conversion of aldehydes/ketones into the corresponding dithianes 4, however, 2b was less effective. Moreover, the chemoselectivity of the thioacetalization of 3 in the presence of 2a is discussed.

Kinetics and mechanism of alkaline hydrolysis of malonamide and dicyandiamide

Kinetics of hydrolysis of malonamide and dicyandiamide have been studied in 0.1 to 1.5 mol dm-3 and 0.25 to 2.0 mol dm-3 sodium hydroxide respectively.Malonamide hydrolysis follows irreversible first order consecutive path:Malonamide malonamic acid malonic acid.The variation of k1 and k2 with is in good agreement with equations, 1/k1=B1+B2/-> and 1/k2=C1+C2/->, where B1, B2, C1, and C2 are empirical constants.The mechanism proposed involves monoanionic tetrahedral intermediate.Dicyandiamide hydrolysis follows the path: Dicyandiamide guanylurea guanidine+ammonia+carbondioxide.The variation of observed rate constants with is in good agreement with wquation kobs=B1+B2->.Mechanism of hydrolysis involves both mono and dianionic tetrahedral intermediates and their breakdown to the products is the rate-determining step.

Intramolecular Influence of a Carboxylic Function on Platinium Blue Synthesis. A systematic Study of Complexes Originating from Acid Amides

The use of acid amide as ligand for obtaining platinium blue has been investigated.While blue compounds are generally obtained by using the hydrolysis product of cis-dichlorodiammineplatinum(II) as platinum surce, with such ligands the reaction occurs very readily using potassium tetrachloroplatinate(II).The role of the carboxylic function which offers here a primary ligating site to platinum is evidenced.The compounds obtained have been characterized by UV-visible spectral measurments, Ce(IV) oxydative titration , ESR spectroscopy, and magnetic properties.Antitumoral activity toward leukemia L1210 and sarcoma 180 is reported for two of thesecompounds.As a first step for this antitumor study, these compounds have been found to be inactive toward Leukemia while they presnt intersting activity toward Sarcoma.

Organic compounds substituted heptadeca-5,9- and 5,10-dienoic acid

The present invention provides novel substituted heptadeca-5,9- and 5,10-dienoic acid and similar fatty acid compounds which are derivatives of certain prostaglandins and are potent thromboxane A2 inhibitors. By virtue of this pharmacological property, they represent useful pharmacological agents for a wide variety of purposes.