23588-89-8

Upstream product

• 2062-98-8 perfluoro(2-propoxypropionyl) fluoride 
• 76-37-9 2,2,3,3-tetrafluoropropanol 
• 422-61-7 perfluoropropanoyl fluoride 
• 375-84-8 2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptanoyl fluoride 
• 354-34-7 trifluoroacetyl fluoride 
• 355-80-6 2,2,3,3,4,4,5,5-octafluoropentan-1-ol 
• 73602-61-6 triethylamine tris(hydrogen fluoride) 
• 121-44-8 triethylamine 
• 75-89-8 2,2,2-trifluoroethanol 
• 335-05-7 Trifluoromethanesulfonyl fluoride 
• 354-87-0 pentafluoroethanesulfonyl fluoride 
• 375-01-9 2,2,3,3,4,4,4-heptafluorobutanol 
• 307-35-7 perfluorooctyl sulfofluorure 
• 422-05-9 2,2,3,3,3-pentafluoropropyl alcohol 

Downstream Products

• 23588-89-8 triethylammonium dihydrofluoride 
• 144717-69-1 trans-[Pt(H)(F)(PCy₃)2] 
• 869749-35-9 [(PdMe)2(μ-κ2(P,P)Cy2PCH2PCy2)2(μ-F)][FHF] 
• 1414381-42-2 5-bromo-2-[(4-bromophenoxy)difluoromethyl]-1,3-difluorobenzene 
• 23588-89-8 triethylamine hydrofluoride 
• 929904-84-7 guadecitabine triethylammonium salt 
• 1391728-13-4 1-fluoro-3,3-dimethyl-1,3-dihydro-1λ³-benzo[d][1,2]iodaoxole 

Relevant academic research and scientific papers

Perfluoroalcohols

Perfluorinated primary alcohol adducts with triethylamine were prepared from lower perfluorinated acid fluorides and triethylamine monohydrofluoride. They are stable compounds and may be used as a source of RFO groups in organic syntheses.

Iron(II)-Catalyzed Intermolecular Aminofluorination of Unfunctionalized Olefins Using Fluoride Ion

We herein report a new catalytic method for intermolecular olefin aminofluorination using earth-abundant iron catalysts and nucleophilic fluoride ion. This method tolerates a broad range of unfunctionalized olefins, especially nonstyrenyl olefins that are incompatible with existing olefin aminofluorination methods. This new iron-catalyzed process directly converts readily available olefins to internal vicinal fluoro carbamates with high regioselectivity (N vs F), many of which are difficult to prepare using known methods. Preliminary mechanistic studies demonstrate that it is possible to exert asymmetric induction using chiral iron catalysts and that both an iron-nitrenoid and carbocation species may be reactive intermediates.

Synthesis of trifluoromethyl ethers and difluoro(methylthio)methyl ethers by the reaction of dithiocarbonates with IF5-pyridine-HF

Trifluoromethyl ether and difluoro(methylthio)methyl ether of phenols and aliphatic alcohols were selectively synthesized from the corresponding dithiocarbonates. When IF5-pyridine-HF was used alone in the reaction of the dithiocarbonate, the difluoro(methylthio)methyl ether was selectively formed. On the other hand, by the additional use of Et3N-6HF with IF5-pyridine-HF, trifluoromethyl ether was formed selectively. Various functional groups such as ester, ether, amide, and acetonide could tolerate the reaction conditions, and various functionalized difluoro(methylthio)methyl ethers and trifluoromethyl ethers were synthesized.

ANTISENSE MODULATION OF STEAROYL-COA DESATURASE EXPRESSION

Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided.

Antisense modulation of CDC14A expression

Antisense compounds, compositions and methods are provided for modulating the expression of CDC14A. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CDC14A. Methods of using these compounds for modulation of CDC14A expression and for treatment of diseases associated with expression of CDC14A are provided.

Antisense modulation of CD36 expression

Antisense compounds, compositions and methods are provided for modulating the expression of CD36. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD36. Methods of using these compounds for modulation of CD36 expression and for treatment of diseases associated with expression of CD36 are provided.

Method of preparing monofluoromethyl ethers

A method of preparing fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether (sevoflurane) and structurally related monofluoromethyl ethers in which the monochloromethyl ether precursor thereof is reacted with a sterically hindered tertiary amine hydrofluoride salt.

POLYFLUOROALKYL PERFLUOROCARBOXYLATES

Perfluoroacyl fluorides readily react with polyfluorinated alcohols in the presence of triethylamine, giving the corresponding esters in high yield.

NMR INVESTIGATION OF EQUILIBRIA IN SOLUTIONS OF AMINE HYDROFLUORIDES

The 19F NMR chemical shifts of individual diethylamine and dibutylamine monohydrofluorides in chloroform are 32-33 ppm (on the trifluoroacetic acid scale).The stability of secondary amine monohydrofluorides in organic media is well above that of the corresponding tertiary compounds (the difference in equilibrium constants is as much as three orders of magnitude).The stability of amine monohydrofluorides in solution is determined by the energy and number of intra-and intermolecular hydrogen bonds of the fluoride ion and falls with rise in temperature.

N-methyl-N-alkoxycarbonylsulphenyl-carbamates

N-methyl-N-alkoxycarbonylsulphenyl-carbamates of the formula EQU1 in which R1 is C1-6 alkyl, and R2 is phenyl; naphthyl; indanyl; phenyl, naphthyl or indanyl substituted by trihalomethyl, halogen, nitro, nitrile, dioxanyl, dioxolanyl, methyl-dioxanyl, methyl-dioxolanyl, alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, dialkoxymethyl, alkenoxy, alkynoxy, alkylmercapto, alkenylmercapto, alkynylmercapto or dialkylamino, with up to 6 carbon atoms in each alkyl, alkenyl or alkynyl group; a radical of the formula EQU2 in which R3 and R4 are each alkyl, alkylthio, nitrile or phenyl; or EQU3 in which R5 is hydrogen or C1-6 alkyl, which possess insecticidal, acaricidal, fungicidal, nematocidal and bactericidal properties.