30203-94-2

Upstream product

• 100-14-1 4-nitrobenzyl chloride 
• 108-90-7 chlorobenzene 
• 27297-82-1 4-Brom-benzolsulfonsaeure-(4-nitro-benzyl)-ester 
• 1679-18-1 4-Chlorophenylboronic acid 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 104-03-0 4-nitrobenzeneacetic acid 
• 106-39-8 bromochlorobenzene 
• 42766-39-2 potassium 2-(4-nitrophenyl)acetate 
• 636-98-6 p-nitrobenzene iodide 
• 149923-10-4 (4-chlorobenzyl)zinc(II) chloride 
• 619-73-8 4-nitrobenzyl chloride 
• 7446-70-0 aluminium trichloride 

Downstream Products

• 7497-60-1 (4-Chlorophenyl)(4-nitrophenyl)methanone 
• 50275-07-5 4-amino-4'-chlorodiphenylmethane 
• 71969-52-3 3,4'-diamino-4-chloro-benzophenone 
• 4913-77-3 4-amino-4'-chlorobenzophenone 
• 37567-38-7 4-chloro-3,4'-dinitro benzophenone 

Relevant academic research and scientific papers

Dual copper- and photoredox-catalysed C(sp2)-C(sp3) coupling

The use of copper catalysis with visible light photoredox catalysis in a cooperative fashion has recently emerged as a versatile means of developing new C-C bond forming reactions. In this work, dual copper and photoredox catalysis is exploited to effect C(sp2)-C(sp3) cross-couplings between aryl boronic acids and benzyl bromides.

Palladium-catalyzed decarboxylative coupling of potassium nitrophenyl acetates with aryl halides

A palladium-catalyzed decarboxylative cross-coupling of potassium 2- and 4-nitrophenyl acetates with aryl chlorides and bromides has been developed. Because the nitro group can be readily converted to many other functional groups, the new reaction provides a useful method for the preparation of diverse 1,1-diaryl methanes and their derivatives.

Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors

Human immunodeficiency virus type 1 (HIV-1) integrase is a crucial target for antiretroviral drugs, and several keto - enol acid class (often referred to as diketo acid class) inhibitors have clinically exhibited-marked antiretroviral activity. Here, we show the synthesis and the detailed structure - activity relationship of the quinolone carboxylic acids as a novel monoketo acid class of integrase inhibitors. 6-(3-Chloro-2-fluorobenzyl)-1-((2S)-1-hydroxy-3,3- dimethylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 51, which showed an IC50 of 5.8 nMin the strand transfer assay and an ED50 of 0.6 nMin the antiviral assay, and 6-(3-chloro-2-fluorobenzyl) -1-((2S)-1-hydroxy-3-methylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3- carboxylic acid 49, which had an IC50 of 7.2 nMand an ED50 of 0.9 nM, were the most potent compounds in this class. The monoketo acid 49 was much more potent at inhibiting integrasecatalyzed strand transfer processes than 3′-processing reactions, as is the case with the keto - enol acids. Elvitegravir 49 was chosen as a candidate for further studies and is currently in phase 3 clinical trials.