3034-10-4

Basic information

• Product Name: 2-(4-CHLOROPHENYL)CHROMAN-4-ONE
• Synonyms: 4'-Chloroflavanone;NSC 50190;2-(4-CHLOROPHENYL)CHROMAN-4-ONE
• CAS NO: 3034-10-4
• Molecular Formula: C₁₅H₁₁ClO₂
• Molecular Weight: 258.6996
• Mol File: 3034-10-4.mol
• Article Data: 45

Chemical Properties

• Melting Point: 185-187℃
• Boiling Point: 411.9°Cat760mmHg
• Flash Point: 172.9°C
• Appearance: /
• Density: 1.293g/cm³
• Vapor Pressure: 5.41E-07mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: 2-(4-CHLOROPHENYL)CHROMAN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROPHENYL)CHROMAN-4-ONE(3034-10-4)
• EPA Substance Registry System: 2-(4-CHLOROPHENYL)CHROMAN-4-ONE(3034-10-4)

Safety Data

• Hazardous Substances Data: 3034-10-4(Hazardous Substances Data)

Usage

Structure

Chroman-4-one derivative with a chlorophenyl group at the 2-position of the chroman ring

Pharmacological properties

Potential anti-inflammatory, anti-cancer, antioxidant, and neuroprotective activities

Cytotoxic effects

Exhibited against various cancer cell lines

Therapeutic potential

Possible use as a therapeutic agent

Further research needed

To fully understand its biological activities and potential applications.

InChI:InChI=1/C15H11ClO2/c16-11-7-5-10(6-8-11)15-9-13(17)12-3-1-2-4-14(12)18-15/h1-8,15H,9H2

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 108-95-2 phenol 
• 1469-94-9 1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione 
• 22105-07-3 3-(4-chlorophenyl)-1-(2-hydroxyphenyl)propan-1-one 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 1679-18-1 4-Chlorophenylboronic acid 
• 3055-86-5 3-phenoxypropionitrile 
• 873-73-4 4-n-chlorophenylacetylene 
• 90-02-8 salicylaldehyde 
• 533-58-4 2-Iodophenol 
• 29805-11-6 1-(4-chlorophenyl)prop-2-yn-1-ol 
• 491-38-3 1-benzopyran-4(4H)-one 
• 132971-93-8 2'-hydroxy-4-chlorochalcone 

Downstream Products

• 1313611-88-9 2-(4-chlorophenyl)-2,3-dihydro-2'H-spiro[chromene-4,5'-[1,3]oxazolidin]-2'-one 
• 1313611-96-9 ethyl [2-(4-chlorophenyl)-2'-oxo-2,3-dihydro-3'H-spiro[chromene-4,5'-[1,3]oxazolidin]-3'-yl]acetate 
• 1313611-59-4 [2-(4-chlorophenyl)-2'-oxo-2,3-dihydro-3'H-spiro[chromene-4,5'-[1,3]oxazolidin]-3'-yl]acetic acid 
• 126784-71-2 (S)-(-)-2-(4-chlorophenyl)chroman-4-one 
• 1413394-14-5 (R)-(-)-2-(4-chlorophenyl)chroman-4-one 
• 19275-70-8 3-Hydroxy-4'-chloroflavone 
• 60313-84-0 (+/-)-cis-4'-chloroflavan-4-ol 
• 138846-95-4 2-(4-chlorophenyl)-3,4-dihydro-5-benzodioxepin-4-one 
• 132351-67-8 3-(4-chlorophenyl)-4H-1-benzopyran-4-one 
• 10420-75-4 4'-chloroflavone 

Relevant articles and documents

Convenient synthesis of flavanone derivatives via oxa-Michael addition using catalytic amount of aqueous cesium fluoride

A total of 36 flavanones, which included polycyclic aromatic and heterocyclic rings, were readily synthesized via oxa-Michael addition from the corresponding hydroxychalcones with a catalytic amount of aqueous cesium fluoride solution under mild conditions. This method could be applied to the scalable synthesis of eriodictyol as a known potent inhibitor of the SARS-CoV-2 spike protein.

Glycolytic inhibition and antidiabetic activity on synthesized flavanone scaffolds with computer aided drug designing tools

Background: Diabetes mellitus is a challengeable metabolic disorder that leads to a group of complications when the HbA1c level is not maintained. Most of the existing drugs avail-able in the market in long-term use may lead to serious adverse effects. He

Organocatalytic Approach for Assembling Flavanones via a Cascade 1,4-Conjugate Addition/oxa-Michael Addition between Propargylamines with Water

A DBU-catalyzed one-pot cascade reaction of propargylamines and water for the synthesis of flavanones has been developed. This process proceeds via a sequence of 1,4-conjugate addition of water to alkynyl o-quinone methide (o-AQM), followed by the alkyne-allene isomerization and subsequent intramolecular oxa-Michael addition. This strategy provides a convenient method for accessing a broad range of flavanones in good to excellent yields with good functional-group tolerance, in particular, the reactive halo functional groups.