30464-12-1

Usage

Properties

1. Chemical Name: 2-amino-6-ethoxy-4-phenylpyridine-3,5-dicarbonitrile
2. Molecular Formula: \textC17\textH15\textN5\textO
3. Structure: Pyridine derivative with carbonitrile groups attached at positions 3 and 5.
4. Biological Activity: Potential involvement in pharmaceutical research and drug development.
5. Specific Applications: Studied for potential anti-cancer properties and interactions with enzymes and receptors.
6. Importance: Synthesis and characterization are crucial for understanding its biological properties and medicinal applications.

Chemical Structure

Pyridine ring with amino, ethoxy, and phenyl substituents, and carbonitrile groups at positions 3 and 5.

Biological Studies

Research focuses on anti-cancer potential and interactions with enzymes and receptors.

Medicinal Applications

Potential use in drug development and pharmaceutical research.

Synthesis and Characterization

Essential for understanding its properties and applications in medicine.

Upstream product

• 96583-92-5 6-amino-2-chloro-4-phenylpyridine-3,5-dicarbonitrile 
• 141-52-6 sodium ethanolate 
• 100-52-7 benzaldehyde 
• 109-77-3 malononitrile 
• 64-17-5 ethanol 
• 1128-87-6 1-(piperidin-1-yl)-butane-1,3-dione 
• 110-89-4 piperidine 
• 109-89-7 diethylamine 
• 123-75-1 pyrrolidine 
• 110-91-8 morpholine 
• 2700-22-3 Benzylidenemalononitrile 

Downstream Products

• 97118-97-3 2-amino-6-(butylamino)-4-phenylpyridine-3,5-dicarbonitrile 
• 97118-99-5 N-(3,5-Dicyano-6-ethoxy-4-phenyl-pyridin-2-yl)-formimidic acid ethyl ester 
• 97118-98-4 2-amino-6-benzylamino-4-phenylpyridine-3,5-dicarbonitrile 
• 197646-00-7 4-Chloro-2-dimethylamino-7-ethoxy-5-phenyl-pyrido[2,3-d]pyrimidine-6-carbonitrile 

Relevant academic research and scientific papers

Synthesis of Some New Polyfunctionalized Pyridines

5-Methyl-2,4-dihydro-3H-pyrazol-3-one and/or 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one was reacted with arylidenemalononitrile in the presence of sodium alkoxide to give 2-amino-6-alkoxy-4-arylpyridine-3,5-dicarbonitrile 4a–e instead of the reported pyrazolo[3,4-b]pyridine-5-carbonitriles. The same products 4a–e were prepared via reaction of arylidenemalononitrile with sodium alkoxide in an appropriative alcohol. However, the new synthetic route for preparation of their positional isomer 4-amino-6-alkoxy-2-arylpyridine-3,5-dicarbonitrile 7a–j has been achieved via reaction of 2-aminoprop-1-ene-1,1,3-tricarbonitrile with different aromatic aldehydes under the same conditions.

Reusable Ce-V Loaded Alumina Catalyst for Multicomponent Synthesis of Substituted Pyridines in Green Media

Ce-V/Al2O3 as an effective heterogeneous catalyst is synthesized by a simple technique. The catalyst was identified by powder X-ray diffraction, SEM, TEM, and BET surface area analysis. The catalyst is fully recyclable and reusable for several runs preser

Transformation of 2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitrile into 4-aminopyrido[2,3-d]pyrimidines and 2-(pyrid-2-yl)guanidines

The reactions of 2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitrile (14) with a range of primary and secondary amines are investigated. Treatment with n-BuNH2 and BnNH2 gave 1,3-di-n-butyl- and 1,3-dibenzyl-2-(3,5-dicyano-6-ethoxy-4-phenylpyrid-2-yl)guanidines 15a (32%) and 15b (82%), respectively. While treatment with Et2NH, n-Pr2NH or Bn2NH gave the analogous 4-dialkylaminopyrido[2,3-d]pyrimidines 16c-e in high yields. Treatment of the dithiazole 14 with pyrrolidine, piperidine or morpholine gave the analogous 4-dialkylaminopyrido[2,3-d]pyrimidines 16f-h, the 2-aminopyridine 13 and 2-(diamino-1-ylmethyleneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitriles 15f-h. The 4-dialkylaminopyrido[2,3-d]pyrimidines 16f-h are converted to the 2-(dialkylamino-1-ylmethyleneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitriles 15f-h upon further reaction with excess dialkylamines. The structure and origins of the two side products 17 and 18 are also discussed. Tentative mechanisms for these transformations are proposed.

A facile one-pot synthesis of 2-thioxo-dihydropyrimidines and polyfunctionalized pyran derivatives as mimics of novel calcium channel modulators

An efficient protocol for the synthesis of pharmacologically significant dihydropyrimidines and polyfunctionalized pyrans is described by performing a one-pot multicomponent reaction (MCR). A chemistry-driven drug discovery approach is implemented by keep

Multi-component synthesis of 6-alkoxy-2-amino-3,5-dicyanopyridines

An efficient one-pot synthesis of mono- and bis-6-alkoxy-2-amino-3,5- dicyanopyridines via a four or pseudoseven-component reaction of aldehyde, malononitrile and alcohol using K2CO3 as the base is described.

Synthesis and pharmacological activity of some nitrofuraldehyde cyanopyridine derivatives

Compounds 3a-f were obtained by condensing 5-nitrofuraldehyde hydrazone with five iminoethers derived from the 6-alkoxy-(or alkylamino-)2-amino-4-aryl-3,5-dicyanopyridines. Tests of their antimicrobial activity against 16 micro-organisms showed that 3a (R