3070-86-8

Basic information

• Product Name: N,N'-(OXYDI-4,1-PHENYLENE)BISACETAMIDE
• Synonyms: N,N'-(OXYDI-4,1-PHENYLENE)BISACETAMIDE;44DIACETAMIDODIPHENYLETHER;Bis(p-acetylaminophenyl) Ether;N,N'-(oxybis(4,1-phenylene))diacetamide;Acetaminophen Impurity N
• CAS NO: 3070-86-8
• Molecular Formula: C₁₆H₁₆N₂O₃
• Molecular Weight: 284.31
• Mol File: 3070-86-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 230-231 °C(lit.)
• Boiling Point: 554.4°Cat760mmHg
• Flash Point: 289.1°C
• Appearance: /
• Density: 1.256g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 14.16±0.70(Predicted)
• CAS DataBase Reference: N,N'-(OXYDI-4,1-PHENYLENE)BISACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-(OXYDI-4,1-PHENYLENE)BISACETAMIDE(3070-86-8)
• EPA Substance Registry System: N,N'-(OXYDI-4,1-PHENYLENE)BISACETAMIDE(3070-86-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 3070-86-8(Hazardous Substances Data)

Usage

Uses

N,N'-(Oxydi-4,1-Phenylene)Bisacetamide is a chemical reagent used in the synthesis of photosensitive polymer compounds and optical application. It also is used in the preparation of benzimidazole derivatives displaying anti-tumor activity through apoptosis.

Upstream product

• 101-80-4 4,4'-oxydiphenylene diamine 
• 64-19-7 acetic acid 
• 2687-41-4 N-[4-(4-aminophenoxy)phenyl]acetamide 
• 108-24-7 acetic anhydride 
• 100-02-7 4-nitro-phenol 
• 824-78-2 4-nitrophenol sodium salt 
• 100-00-5 4-chlorobenzonitrile 
• 15267-98-8 sodium 4-aminophenolate 
• 6149-33-3 4-(4-nitrophenoxy)aniline 
• 103-90-2 4-acetaminophenol 
• 2687-40-3 4-nitrophenyl 4'-acetamidophenyl ether 
• 101-63-3 bis(4-nitrophenyl)ether 

Downstream Products

• 894734-47-5 5,5'-oxy-bis[2-(4'-methoxyphenyl)-1H-benzimidazole] 
• 1403460-70-7 5,5'-oxy-bis[2-(3',5'-dimethoxyphenyl)-1H-benzimidazole] 
• 1403460-75-2 5,5'-oxy-bis[2-(4'-fluorophenyl)-1H-benzimidazole] 
• 1403460-74-1 5,5'-oxy-bis[2-(2',4'-dichlorophenyl)-1H-benzimidazole] 
• 1403460-73-0 5,5'-oxy-bis[2-(4'-bromophenyl)-1H-benzimidazole] 
• 73672-91-0 2,2'-diphenyl-5,5'-bisbenzimidazolyl ether 
• 1403460-72-9 5,5'-oxy-bis[2-(3'-methoxy-4'-hydroxyphenyl)-1H-benzimidazole] 
• 1403460-71-8 5,5'-oxy-bis[2-(3',4',5'-trimethoxyphenyl)-1H-benzimidazole] 
• 2676-59-7 bis(3,4-diaminophenyl)ether 
• 3273-78-7 4-(4-amino-3-nitrophenoxy)-2-nitrophenylamine 
• 3070-87-9 N-[4-(4-acetylamino-3-nitrophenoxy)-2-nitrophenyl]acetamide 

Relevant articles and documents

Preparation method 3,3 '-dinitro -4, 4' - diacetyl diaminodiphenyl ether

The preparation method of 3, 3 ’ -dinitro -4 and 4 ’ -diacetyl diaminodiphenyl ether comprises the following steps of: adding an acylating agent to 4 and 4 ’ - diaminodiphenyl ether to carry out acylation reaction to obtain an acylation product. The nitra

Newly synthesized bis-benzimidazole derivatives exerting anti-tumor activity through induction of apoptosis and autophagy

In this study, a new series of bis-benzimidazole derivatives were designed and synthesized. Most of these new compounds showed significant anti-tumor activity in vitro compared to Hoechst 33258. Among them, the most potent compound 8 had the IC50/su

Synthesis and Anthelmintic Activity of 2-Substituted 5(6)-(5-Benzimidazolyloxy)- and 5(6)-Aryloxybenzimidazoles

A number of diaryl oxides (12-17 and 22-35) and 2,2'-disubstituted-5,5'-dibenzimidazolyl oxides (18-21) have been synthesized starting from 4-nitrophenol and 4-acetaminophenol respectively.All the compounds have been evaluated for their anthelmintic activity against Ancylostoma ceylanicum in hamsters, Nippostrongylus brasiliensis and Hymenolepsis nana in rats and Syphacia obvelata in mice.The results show that compounds 18, 19 and 33 remove 100percent of A. ceylanicum and H. nana at a single oral dose of 12.5-250 mg/kg.Compound 18 is also effective against N. brasiliensis in rats and S. obvelata in mice.