31407-74-6

Basic information

• Product Name: O-Ethylisourea hydrochloride
• Synonyms: O-ETHYLISOUREA HYDROCHLORIDE;2-ethylisouronium chloride;2-ethylisoureaHCl;2-ethylisoureahydrochloride;ETHYLIMIDOCARBAMATEHYDROCHLORIDE;ethyl carbaMiMidate hydrochloride;CarbaMiMidic acid,ethyl ester, Monohydrochloride (9CI);2-ethylisourea
• CAS NO: 31407-74-6
• Molecular Formula: C₃H₈N₂O*ClH
• Molecular Weight: 124.57
• EINECS: 250-617-6
• Product Categories: Small molecule
• Mol File: 31407-74-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 99-101 °C
• Boiling Point: 95.3 °C at 760 mmHg
• Flash Point: 11.4 °C
• Appearance: /
• Vapor Pressure: 45.8mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: O-Ethylisourea hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: O-Ethylisourea hydrochloride(31407-74-6)
• EPA Substance Registry System: O-Ethylisourea hydrochloride(31407-74-6)

Safety Data

• Hazardous Substances Data: 31407-74-6(Hazardous Substances Data)

Usage

Uses

O-Ethylisourea, HCl

InChI:InChI=1/C3H8N2O.ClH/c1-2-6-3(4)5;/h2H2,1H3,(H3,4,5);1H

Synthetic route

ethanol (64-17-5) + CYANAMID (420-04-2) + cyanamide dihydrochloride (23918-45-8, 145059-61-6) → O-ethyl-isourea hydrochloride (31407-74-6)

ethanol (64-17-5) + CYANAMID (420-04-2) → O-ethyl-isourea hydrochloride (31407-74-6)

Conditions	Yield
With hydrogenchloride

compound CH3SC(OC2H5)NH → O-ethyl-isourea hydrochloride (31407-74-6)

Conditions	Yield
With ethanol; ammonium chloride

O-ethyl-isourea hydrochloride (31407-74-6) + methyl chloroformate (79-22-1) → N-Methoxycarbonyl-O-(ethyl)isoharnstoff (52234-95-4)

Conditions	Yield
With sodium hydroxide In dichloromethane; water for 2h; Ambient temperature;	92%

O-ethyl-isourea hydrochloride (31407-74-6) + 3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one (55314-16-4, 75415-01-9, 123367-26-0) → 2-ethoxy-4-(3-pyridyl)pyrimidine

Conditions	Yield
With sodium hydroxide In methanol at 65℃; for 8h; Temperature; Solvent;	91.9%

3-ethoxy-spiro[3.5]nonan-1-one (1051379-48-6) + O-ethyl-isourea hydrochloride (31407-74-6) → 4-cyclohexyl-2-ethoxypyrimidine

Conditions	Yield
Stage #1: O-ethyl-isourea hydrochloride With potassium phosphate In acetonitrile at 20℃; for 1h; Sealed tube; Stage #2: 3-ethoxy-spiro[3.5]nonan-1-one With boron trifluoride diethyl etherate In acetonitrile at 80℃; for 18h; Sealed tube;	80%

O-ethyl-isourea hydrochloride (31407-74-6) + chloro(chlorosulfanyl)methanone (2757-23-5) → ethoxy-3 thiadiazol-1,2,4 ol-5 (75465-39-3)

Conditions	Yield
With sodium carbonate In dichloromethane at 20℃; for 16h;	71%

O-ethyl-isourea hydrochloride (31407-74-6) → chloroethane (75-00-3)

Conditions	Yield
at 123 - 124℃;

O-ethyl-isourea hydrochloride (31407-74-6) → O-ethyl-N-chloro-isourea (54953-43-4)

Conditions	Yield
With sodium hypochlorite

O-ethyl-isourea hydrochloride (31407-74-6) → O-ethyl-N-bromo-isourea

Conditions	Yield
With sodium hypobromide

O-ethyl-isourea hydrochloride (31407-74-6) + methyl thioisocyanate (556-61-6) → N-ethoxycarboximidoyl-N'-methyl-thiourea (88871-66-3)

Conditions	Yield
With sodium; acetone

5-bromo-2-methoxycyclohepta-2,4,6-trien-1-one (33816-51-2) + sodium ethanolate (141-52-6) + O-ethyl-isourea hydrochloride (31407-74-6) → O-Aethyl-N-(2-aethoxy-tropon-5-yl)-isoharnstoff (21578-78-9)

<2,4,6-Trimethyl-benzoyl>-isothiocyanat (32709-74-3) + O-ethyl-isourea hydrochloride (31407-74-6) → N-(2-Ethyl-isoureidocarbothioyl)-2,4,6-trimethyl-benzamide (32832-49-8)

Conditions	Yield
With sodium hydroxide

O-ethyl-isourea hydrochloride (31407-74-6) → ethyl N'-hydroxyimidocarbamate (18218-05-8)

Conditions	Yield
With hydroxylamine

O-ethyl-isourea hydrochloride (31407-74-6) + 2-phenoxy-benzo[e][1,3]oxazin-4-one (728-74-5) → 2-ethyl-1-(4-oxo-4H-benzo[e][1,3]oxazin-2-yl)-isourea (38374-89-9)

Conditions	Yield
(i) NaOMe, MeOH, (ii) /BRN= 748818/, acetone; Multistep reaction;

O-ethyl-isourea hydrochloride (31407-74-6) + 2-<2-(N-ethylamino)-4-pyridyl>-2,2-diethoxyethylamine (80882-63-9) → N-[2,2-Diethoxy-2-(2-ethylamino-pyridin-4-yl)-ethyl]-guanidine

Conditions	Yield
In ethanol for 1h; Heating;

O-ethyl-isourea hydrochloride (31407-74-6) + benzenesulfonyl chloride (98-09-9) + diluted NaOH → O-ethyl-N-benzenesulfonyl-isourea (854695-24-2)

Conditions	Yield
reagiert analog mit p-Toluolsulfochlorid oder α-Naphthalinsulfochlorid;

ammonia (7664-41-7) + O-ethyl-isourea hydrochloride (31407-74-6) → guanidine hydrochloride (50-01-1)

O-ethyl-isourea hydrochloride (31407-74-6) + diethyl malonate (105-53-3) → monosodium salt of 2-ethoxy-4,6-dihydroxypyrimidine (181210-42-4)

Conditions	Yield
In ethanol

Methyl 4-chloroacetoacetate (32807-28-6) + O-ethyl-isourea hydrochloride (31407-74-6) → 2-ethoxy-4-chloromethyl-6-hydroxy-pyrimidine (94171-01-4)

Conditions	Yield
With sodium hydroxide In water

O-ethyl-isourea hydrochloride (31407-74-6) + diethyl malonate (105-53-3) → 2-ethoxy-4,6-dihydroxypyrimidine (61636-08-6)

Conditions	Yield
With hydrogenchloride; sodium ethanolate In ethanol; water

O-ethyl-isourea hydrochloride (31407-74-6) + 1-Bromopinacolon (5469-26-1) → 4-(tert-butyl)-2-ethoxy-1H-imidazole

Conditions	Yield
With sodium hydrogencarbonate In ethanol at 50℃; for 15h;	230 mg

2-bromo-1-(6-methoxypyridin-3-yl)ethan-1-one + O-ethyl-isourea hydrochloride (31407-74-6) → 5-(2-ethoxy-1H-imidazol-4-yl)-2-methoxypyridine

Conditions	Yield
With sodium hydrogencarbonate In ethanol at 65℃; for 5h; Inert atmosphere;	200 mg

Upstream product

• 64-17-5 ethanol 
• 420-04-2 CYANAMID 
• 23918-45-8 cyanamide dihydrochloride 

Downstream Products

• 75-00-3 chloroethane 
• 32832-49-8 N-(2-Ethyl-isoureidocarbothioyl)-2,4,6-trimethyl-benzamide 
• 61636-08-6 2-ethoxy-4,6-dihydroxypyrimidine 
• 50-01-1 guanidine hydrochloride 
• 21578-78-9 O-Aethyl-N-(2-aethoxy-tropon-5-yl)-isoharnstoff 

Relevant articles and documents

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