35144-39-9

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(4-methoxyphenyl)-2-methylpropan-2-ol is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new medications.
Used as a Fragrance Ingredient:
In the perfumery and personal care products industry, 1-(4-methoxyphenyl)-2-methylpropan-2-ol is used as a fragrance ingredient, capitalizing on its sweet scent to enhance the olfactory profiles of these products.
Used in Flavor and Fragrance Production:
1-(4-methoxyphenyl)-2-methylpropan-2-ol is utilized in the production of flavors and fragrances, where its aromatic properties can be employed to create or modify the sensory characteristics of various products.
Used as a Chiral Auxiliary in Organic Synthesis:
In organic synthesis, 1-(4-methoxyphenyl)-2-methylpropan-2-ol serves as a chiral auxiliary, playing a crucial role in the synthesis of enantiomerically pure compounds, which is vital for the production of many pharmaceuticals and agrochemicals.
Safety Precautions:
It is important to handle 1-(4-methoxyphenyl)-2-methylpropan-2-ol with care, as it may pose health risks if ingested, inhaled, or comes into contact with the skin, highlighting the need for proper safety measures during its use in various applications.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 98815-47-5 1-chloro-2-(4-methoxyphenyl)propan-2-ol 
• 917-54-4 methyllithium 
• 115348-15-7 N,N-diethyl-2-(4-methoxyphenyl)acetamide 
• 75-16-1 methylmagnesium bromide 
• 98815-48-6 1-bromo-2-(4-methoxyphenyl)propan-2-ol 
• 23304-25-8 p-methoxyphenyldiazomethane 
• 67-63-0 isopropyl alcohol 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 14062-18-1 ethyl p-methoxyphenylacetate 
• 104-93-8 p-methylanizole 
• 67-64-1 acetone 
• 122-84-9 4-methoxybenzyl methyl ketone 
• 74-88-4 methyl iodide 

Downstream Products

• 18503-98-5 2-Methyl-2-chlor-3-<4-methoxy-phenyl>-propan 
• 877-99-6 1-methoxy-4-(2-methyl-1-propenyl)benzene 
• 736143-80-9 (S)-2-[2-(4-Methoxy-phenyl)-1,1-dimethyl-ethoxycarbonylamino]-hexanoic acid methyl ester 
• 959842-13-8 C₁₁H₁₅FO 
• 926319-48-4 6-(phenylmethoxy)-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride 
• 869477-96-3 Olodaterol hydrochloride 
• 1357290-55-1 KMI-1881 
• 1373041-95-2 C₂₀H₃₂N₂O₂ 
• 1357290-78-8 KMI-1880 

Relevant academic research and scientific papers

Direct and Unified Access to Carbon Radicals from Aliphatic Alcohols by Cost-Efficient Titanium-Mediated Homolytic C?OH Bond Cleavage

Low-valent Ti-mediated homolytic C?O bond cleavage offers unified access to carbon radicals from ubiquitous non-activated tertiary, secondary, and even primary alcohols. In contrast to the representative Ti reagents, which were ineffective for this purpos

Direct Photoexcitation of Ethynylbenziodoxolones: An Alternative to Photocatalysis for Alkynylation Reactions**

Ethynylbenziodoxolones (EBXs) are commonly used as radical traps in photocatalytic alkynylations. Herein, we report that aryl-substituted EBX reagents can be directly activated by visible light irradiation. They act as both oxidants and radical traps, alleviating the need for a photocatalyst in several reported EBX-mediated processes, including decarboxylative and deboronative alkynylations, the oxyalkynylation of enamides and the C?H alkynylation of THF. Furthermore, the method could be applied to the synthesis of alkynylated quaternary centers from tertiary alcohols via stable oxalate salts and from tertiary amines via aryl imines. A photocatalytic process using 4CzIPN as an organic dye was also developed for the deoxyalkynylation of oxalates.

Highly Chemoselective gem-Difluoropropargylation of Aliphatic Alcohols

Despite the potential of α-fluoroethers in medicinal chemistry, their synthetic methods, especially etherification of aliphatic alcohols, have been limited. Herein, we developed two- and three-step gem-difluoropropargylation of aliphatic alcohols includin

Photocatalytic carbanion generation from C-H bonds-reductant free Barbier/Grignard-type reactions

We report a redox-neutral method for the generation of carbanions from benzylic C-H bonds in a photocatalytic Grignard-type reaction. The combination of photo- and hydrogen atom transfer (HAT) catalysis enables the abstraction of a benzylic hydrogen atom, generating a radical intermediate. This radical is reduced in situ by the organic photocatalyst to a carbanion, which is able to react with electrophiles such as aldehydes or ketones, yielding homobenzylic secondary and tertiary alcohols.

Synergistic Catalysis for the Umpolung Trifluoromethylthiolation of Tertiary Ethers

The first transition-metal-free, site-specific umpolung trifluoromethylthiolation of tertiary alkyl ethers has been developed, achieving the challenging tertiary C(sp3)–SCF3 coupling under redox-neutral conditions. The synergism of organophotocatalyst 4CzIPN and BINOL-based phosphorothiols can site-selectively cleave tertiary sp3 C(sp3)–O ether bonds in complex molecules initiated by a polarity-matching hydrogen-atom-transfer (HAT) event. The incorporation of several competing benzylic and methine C(sp3)?H bonds in alkyl ethers has little influence on the regioselectivity. Selective difluoromethylthiolation of C?O bonds has also been achieved. This represents not only an important step forward in trifluoromethylthiolation but also a promising means for site-selective C?O bond functionalization of unsymmetrical tertiary alkyl ethers.

A Process for Preparing Olodaterol and Intermediates Thereof

The present invention relates to a process for preparing olodaterol and intermediates thereof. The process comprises of forming compound of Formula 1 by reacting compound of Formula 2 or its acid salt with compound of Formula 3 in the presence of an organ

Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox-Neutral Fragment Coupling

Alkyl oxalates are new bench-stable alcohol-activating groups for radical generation under visible light photoredox conditions. Using these precursors, the first net redox-neutral coupling of tertiary and secondary alcohols with electron-deficient alkenes is achieved.

Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design

Previously reported pentapeptidic BACE1 inhibitors, designed using a substrate-based approach, were used as lead compounds for the further design of non-peptidic BACE1 inhibitors. Although these peptidic and non-peptidic inhibitors, with a hydroxymethylcarbonyl isostere as a substrate transition-state mimic, exhibited potent BACE1 inhibitory activities, their molecular-sizes appeared a little too big (molecular weight of >600 daltons) for developing practical anti-Alzheimer's disease drugs. To develop lower weight BACE1 inhibitors, a series of tripeptidic BACE1 inhibitors were devised using a design approach based on the conformation of a virtual inhibitor bound to the BACE1 active site, also called 'in-silico conformational structure-based design'. Although these tripeptidic BACE1 inhibitors contained some natural amino acid residues, they are expected to be useful as lead compounds for developing the next generation BACE1 inhibitors, due to their low molecular size and unique structural features compared with previously reported inhibitors.

Pd(II)-catalyzed hydroxyl-directed C-H olefination enabled by monoprotected amino acid ligands

A novel Pd(II)-catalyzed ortho-C-H olefination protocol has been developed using spatially remote, unprotected tertiary, secondary, and primary alcohols as the directing groups. Mono-N-protected amino acid ligands were found to promote the reaction, and an array of olefin coupling partners could be used. When electron-deficient alkenes were used, the resulting olefinated intermediates underwent subsequent Pd(II)-catalyzed oxidative intramolecular cyclization to give the corresponding pyran products, which could be converted into ortho-alkylated alcohols under hydrogenolysis conditions. The mechanistic details of the oxidative cyclization step are discussed and situated in the context of the overall catalytic cycle.

SMALL MOLECULE INHIBITORS OF NAVL.7 SODIUM CHANNELS FOR THE TREATMENT OF PAIN DISORDERS

The present invention relates to 2 -substituted, 1,1- diarylethanol compounds of formula I, which are inhibitors of the sodium channel NaVl.7, and the use of such compounds in the manufacture of medicaments for the treatment of pain.