35144-39-9

Basic information

• Product Name: 1-(4-methoxyphenyl)-2-methylpropan-2-ol
• Synonyms: 1-(4-methoxyphenyl)-2-methylpropan-2-ol
• CAS NO: 35144-39-9
• Molecular Weight: 180.247
• Mol File: 35144-39-9.mol
• Article Data: 19

Chemical Properties

• Melting Point: 40-41 °C(Solv: hexane (110-54-3))
• Boiling Point: 276.7±15.0 °C(Predicted)
• Density: 1.019±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-(4-methoxyphenyl)-2-methylpropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)-2-methylpropan-2-ol(35144-39-9)
• EPA Substance Registry System: 1-(4-methoxyphenyl)-2-methylpropan-2-ol(35144-39-9)

Safety Data

• Hazardous Substances Data: 35144-39-9(Hazardous Substances Data)

Usage

General Description

1-(4-methoxyphenyl)-2-methylpropan-2-ol is a chemical compound that belongs to the class of alcohols. It is also known as p-methoxyphenyl isobutyl carbinol and has the molecular formula C11H16O2. 1-(4-methoxyphenyl)-2-methylpropan-2-ol is a clear, colorless liquid at room temperature with a faint, sweet odor. It is used in the synthesis of pharmaceuticals and as a fragrance ingredient in perfumes and personal care products. Additionally, 1-(4-methoxyphenyl)-2-methylpropan-2-ol has potential applications in the production of flavors and fragrances, as well as in organic synthesis as a chiral auxiliary. However, it is important to handle this compound with care as it may be harmful if ingested, inhaled, or comes in contact with the skin.

Upstream product

• 75-16-1 methylmagnesium bromide 
• 98815-48-6 1-bromo-2-(4-methoxyphenyl)propan-2-ol 
• 23304-25-8 p-methoxyphenyldiazomethane 
• 67-63-0 isopropyl alcohol 
• 917-64-6 methyl magnesium iodide 
• 2196-99-8 2-chloro-1-(4-methoxyphenyl)ethanone 
• 558-30-5 2-methyl-1,2-epoxypropane 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 104-93-8 p-methylanizole 
• 67-64-1 acetone 
• 122-84-9 4-methoxybenzyl methyl ketone 
• 676-58-4 methylmagnesium chloride 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 31179-52-9 p-anisylmagnesium bromide 

Downstream Products

• 18503-98-5 2-Methyl-2-chlor-3-<4-methoxy-phenyl>-propan 
• 16166-66-8 1-p-Methoxybenzyl-1-methylethyl-p-nitroperbenzoat 
• 877-99-6 1-methoxy-4-(2-methyl-1-propenyl)benzene 
• 69986-07-8 N-[2-(4-Hydroxy-phenyl)-1,1-dimethyl-ethyl]-propionamide 
• 736143-80-9 (S)-2-[2-(4-Methoxy-phenyl)-1,1-dimethyl-ethoxycarbonylamino]-hexanoic acid methyl ester 
• 959842-13-8 C₁₁H₁₅FO 
• 133055-09-1 4-(2,2-dimethyl-3-phenylpropyl)-1-methoxybenzene 
• 1357290-78-8 KMI-1880 
• 1373041-95-2 C₂₀H₃₂N₂O₂ 
• 1357290-55-1 KMI-1881 
• 926319-48-4 6-(phenylmethoxy)-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride 
• 869477-96-3 Olodaterol hydrochloride 

Relevant articles and documents

Direct and Unified Access to Carbon Radicals from Aliphatic Alcohols by Cost-Efficient Titanium-Mediated Homolytic C?OH Bond Cleavage

Low-valent Ti-mediated homolytic C?O bond cleavage offers unified access to carbon radicals from ubiquitous non-activated tertiary, secondary, and even primary alcohols. In contrast to the representative Ti reagents, which were ineffective for this purpos

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We report a redox-neutral method for the generation of carbanions from benzylic C-H bonds in a photocatalytic Grignard-type reaction. The combination of photo- and hydrogen atom transfer (HAT) catalysis enables the abstraction of a benzylic hydrogen atom, generating a radical intermediate. This radical is reduced in situ by the organic photocatalyst to a carbanion, which is able to react with electrophiles such as aldehydes or ketones, yielding homobenzylic secondary and tertiary alcohols.

Synergistic Catalysis for the Umpolung Trifluoromethylthiolation of Tertiary Ethers

The first transition-metal-free, site-specific umpolung trifluoromethylthiolation of tertiary alkyl ethers has been developed, achieving the challenging tertiary C(sp3)–SCF3 coupling under redox-neutral conditions. The synergism of organophotocatalyst 4CzIPN and BINOL-based phosphorothiols can site-selectively cleave tertiary sp3 C(sp3)–O ether bonds in complex molecules initiated by a polarity-matching hydrogen-atom-transfer (HAT) event. The incorporation of several competing benzylic and methine C(sp3)?H bonds in alkyl ethers has little influence on the regioselectivity. Selective difluoromethylthiolation of C?O bonds has also been achieved. This represents not only an important step forward in trifluoromethylthiolation but also a promising means for site-selective C?O bond functionalization of unsymmetrical tertiary alkyl ethers.