3551-78-8

Basic information

• Product Name: Ethanediamide, N,N'-bis(phenylmethyl)-
• Synonyms: NSC 97802;Ethanediamide,N,N'-bis(phenylmethyl)- (9CI);Oxamide, N,N'-dibenzyl- (6CI,7CI,8CI);N,N'-Dibenzyloxamide;NSC 117519;NSC 314;N,N'-Dibenzylethanediamide;N-Benzyl-N'-benzylethane-1,2-diamide
• CAS NO: 3551-78-8
• Molecular Formula: C₁₆H₁₆N₂O₂
• Molecular Weight: 268.315
• Mol File: 3551-78-8.mol
• Article Data: 17

Chemical Properties

• Density: 1.177 g/cm³
• CAS DataBase Reference: Ethanediamide, N,N'-bis(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanediamide, N,N'-bis(phenylmethyl)-(3551-78-8)
• EPA Substance Registry System: Ethanediamide, N,N'-bis(phenylmethyl)-(3551-78-8)

Safety Data

• Hazardous Substances Data: 3551-78-8(Hazardous Substances Data)

Usage

General Description

Ethanediamide, N,N'-bis(phenylmethyl)- is a chemical compound that is a derivative of ethanediamide, also known as ethylenediamine. It is an organic compound with the molecular formula C20H24N2 and is commonly used in the production of pharmaceuticals and as a reagent in chemical reactions. Ethanediamide, N,N'-bis(phenylmethyl)- has two phenylmethyl groups bonded to the nitrogen atoms of the ethanediamide molecule, which gives it unique properties and reactivity. Ethanediamide, N,N'-bis(phenylmethyl)- is commonly used as a chelating agent for metal ions and as a building block in the synthesis of more complex organic compounds. It is important to handle this chemical compound with caution and follow proper safety protocols due to its reactivity and potential health hazards.

Upstream product

• 553-90-2 Dimethyl oxalate 
• 100-46-9 benzylamine 
• 1870-16-2 1,1,1,2,5,6,6,6-octafluoro-2,5-bis-trifluoromethyl-hexane-3,4-dione 
• 1619-73-4 ethyl 2-oxo-4-phenylbut-3-ynoate 
• 609-09-6 Diethyl ketomalonate 
• 144-62-7 oxalic acid 
• 75-36-5 acetyl chloride 
• 68462-61-3 ethyl 5‐amino‐1‐benzyl‐1H‐imidazole‐4‐carboxylate 
• 95-92-1 oxalic acid diethyl ester 
• 1924-84-1 1-nitroso-1-phenylmethyl-hydrazine 
• 24431-15-0 N-benzyl-p-tolylmethanimine 
• 55386-79-3 1,3-dioxo-1-(2-hydroxyphenyl)butyl methyl ester 
• 780-25-6 N-benzylidene benzylamine 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 91325-40-5 N,N'-dibenzyl-N,N'-bis(dimethylboryl)ethanediamide 
• 91325-43-8 CH₂C₆H₅NHCOCON(CH₂C₆H₅)B(CH₃)2 
• 100-46-9 benzylamine 
• 19340-77-3 N-Phenylmethyl hydroxyacetamide 
• 21775-46-2 N-p-Anisyl-N'-benzyloxamid 
• 64481-53-4 N,N'-dibenzyl-2,3,5,6-piperazinetetraone 
• 140-28-3 N,N'-Dibenzylethylenediamine 
• 20836-96-8 N,N'-dibenzyl-thiooxalamide 
• 42164-42-1 1,3-dibenzyl-1,3-diazolidine 

Relevant articles and documents

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Synthesis of oxalamides by acceptorless dehydrogenative coupling of ethylene glycol and amines and the reverse hydrogenation catalyzed by ruthenium

A sustainable, new synthesis of oxalamides, by acceptorless dehydrogenative coupling of ethylene glycol with amines, generating H2, homogeneously catalyzed by a ruthenium pincer complex, is presented. The reverse hydrogenation reaction is also accomplished using the same catalyst. A plausible reaction mechanism is proposed based on stoichiometric reactions, NMR studies, X-ray crystallography as well as observation of plausible intermediates.

Cu/ N, N′-Dibenzyloxalamide-Catalyzed N-Arylation of Heteroanilines

N,N′-Dibenzyloxalamide (DBO) was identified as a powerful ligand for promoting Cu-catalyzed coupling of heteroanilines with (hetero)aryl halides. For (hetero)aryl chlorides, the coupling reaction occurred at 130 °C with 5 mol % CuBr and 10 mol % DBO. For