3551-78-8

Usage

Uses

Used in Pharmaceutical Industry:
Ethanediamide, N,N'-bis(phenylmethyl)is utilized as a key intermediate in the production of pharmaceuticals. Its unique structure allows it to form stable complexes with metal ions, making it an effective chelating agent. This property is particularly useful in the development of drugs that require metal ion coordination for their therapeutic effects.
Used in Chemical Reactions as a Reagent:
In the realm of chemical synthesis, Ethanediamide, N,N'-bis(phenylmethyl)serves as a versatile reagent. Its ability to form complexes with metal ions and its reactivity with other organic compounds make it a building block in the synthesis of more complex organic molecules, contributing to the advancement of organic chemistry.
Used in Research and Development:
Ethanediamide, N,N'-bis(phenylmethyl)is also employed in research and development settings. Its unique properties and reactivity make it an interesting subject for studies aimed at understanding the behavior of organic compounds and their interactions with metal ions, which can lead to the discovery of new applications and uses in various fields.
It is crucial to handle Ethanediamide, N,N'-bis(phenylmethyl)with care and adhere to proper safety protocols due to its reactivity and potential health hazards, ensuring the safety of both individuals and the environment.

Upstream product

• 67-56-1 methanol 
• 16560-29-5 1-phenyl-4,5,6,7-tetrahydro-indole-2,3-dione 
• 100-46-9 benzylamine 
• 144-62-7 oxalic acid 
• 553-90-2 Dimethyl oxalate 
• 515-96-8 oxalamic acid hydrazide 
• 5396-14-5 ethyl 2-oxo-2-(2-oxocyclohexyl)acetate 
• 859068-71-6 benzyl-aminooxalyl azide 
• 108-24-7 acetic anhydride 
• 68462-61-3 ethyl 5‐amino‐1‐benzyl‐1H‐imidazole‐4‐carboxylate 
• 75-36-5 acetyl chloride 
• 95-92-1 oxalic acid diethyl ester 
• 1924-84-1 1-nitroso-1-phenylmethyl-hydrazine 
• 7142-72-5 N-benzyloxamic acid ethyl ester 

Downstream Products

• 20836-96-8 N,N'-dibenzyl-thiooxalamide 
• 64481-53-4 N,N'-dibenzyl-2,3,5,6-piperazinetetraone 
• 100-46-9 benzylamine 
• 19340-77-3 N-Phenylmethyl hydroxyacetamide 
• 21775-46-2 N-p-Anisyl-N'-benzyloxamid 
• 91325-43-8 CH₂C₆H₅NHCOCON(CH₂C₆H₅)B(CH₃)2 
• 91325-40-5 N,N'-dibenzyl-N,N'-bis(dimethylboryl)ethanediamide 
• 42164-42-1 1,3-dibenzyl-1,3-diazolidine 
• 140-28-3 N,N'-Dibenzylethylenediamine 

Relevant academic research and scientific papers

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Room Temperature Cu-Catalyzed N-Arylation of Oxazolidinones and Amides with (Hetero)Aryl Iodides

N,N′-Bis(pyridin-2-ylmethyl)oxalamide (BPMO) was found to be an apposite promoter for the Cu-catalyzed N-arylation of oxazolidinones and primary and secondary amides with (hetero)aryl iodides at room temperature. Excellent chemoselectivity reached between

Synthesis of oxalamides by acceptorless dehydrogenative coupling of ethylene glycol and amines and the reverse hydrogenation catalyzed by ruthenium

A sustainable, new synthesis of oxalamides, by acceptorless dehydrogenative coupling of ethylene glycol with amines, generating H2, homogeneously catalyzed by a ruthenium pincer complex, is presented. The reverse hydrogenation reaction is also accomplished using the same catalyst. A plausible reaction mechanism is proposed based on stoichiometric reactions, NMR studies, X-ray crystallography as well as observation of plausible intermediates.

Oxalic Diamides and tert-Butoxide: Two Types of Ligands Enabling Practical Access to Alkyl Aryl Ethers via Cu-Catalyzed Coupling Reaction

A robust and practical protocol for preparing alkyl aryl ethers has been developed, which relies on using two types of ligands to promote Cu-catalyzed alkoxylation of (hetero)aryl halides. The reaction scope is very general for a variety of coupling partners, particularly for challenging secondary alcohols and (hetero)aryl chlorides. In case of coupling with aryl chlorides and bromides, two oxalic diamides serve as the powerful ligands. The tert-butoxide is first demonstrated as a ligand for Cu-catalyzed coupling reaction, leading to alkoxylation of aryl iodides complete at room temperature. Additionally, a number of carbohydrate derivatives are applicable for this coupling reaction, affording the corresponding carbohydrate-aryl ethers in 29-98% yields.

Cu/ N, N′-Dibenzyloxalamide-Catalyzed N-Arylation of Heteroanilines

N,N′-Dibenzyloxalamide (DBO) was identified as a powerful ligand for promoting Cu-catalyzed coupling of heteroanilines with (hetero)aryl halides. For (hetero)aryl chlorides, the coupling reaction occurred at 130 °C with 5 mol % CuBr and 10 mol % DBO. For

Catalytic Oxidative Carbonylation of Amino Moieties to Ureas, Oxamides, 2-Oxazolidinones, and Benzoxazolones

The direct syntheses of ureas, oxamides, 2-oxazolidinones, and benzoxazolones by the oxidative carbonylation of amines, β-amino alcohols, and 2-aminophenols allows us to obtain high value added molecules, which have a large number of important applications in several fields, from very simple building blocks. We have found that it is possible to perform these transformations using the PdI2/KI catalytic system in an ionic liquid, such as 1-butyl-3-methylimidazolium tetrafluoroborate, as the solvent, the solvent/catalyst system can be recycled several times with only a slight loss of activity, and the product can be recovered easily by crystallization.

CuI/Oxalic Diamide Catalyzed Coupling Reaction of (Hetero)Aryl Chlorides and Amines

A class of oxalic diamides are found to be effective ligands for promoting CuI-catalyzed aryl amination with less reactive (hetero)aryl chlorides. The reaction proceeds at 120 °C with K3PO4 as the base in DMSO to afford a wide range of (hetero)aryl amines in good to excellent yields. The bis(N-aryl) substituted oxalamides are superior ligands to N-aryl-N′-alkyl substituted or bis(N-alkyl) substituted oxalamides. Both the electronic nature and the steric property of the aromatic rings in ligands are important for their efficiency.

Recyclization of 2-methoxy-5-morpholino-1,3-oxazole-4-carbonitrile by benzylamine, phenethylamine, and phenylhydrazine

Reaction of 2-methoxy-5-morpholino-1,3-oxazole-4-carbonitrile with benzylamine, phenethylamine and phenylhydrazine results in the new substituted 5-amino-2,3-dihydro-1H-imidazol-2-ones.

Synthesis of 2-alkyl-1-aryl-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione derivatives

A preparative procedure for the synthesis of 2-alkyl-1-aryl-1,2- dihydrochromeno[2,3-c]pyrrole-3,9-diones from methyl 4-(o-hydroxyphenyl)-2,4- dioxobutanoate, aromatic aldehyde, and aliphatic amine is described.

Selective and environmentally friendly methodologies based on the use of electrochemistry for fine chemical preparation: An efficient synthesis of N,N′-disubstituted ureas

A novel efficient synthesis of N,N′-disubstituted ureas has been developed. Aromatic and aliphatic primary amines undergo oxidative carbonylation under atmospheric pressure of carbon monoxide using Pd(II) catalyst in combination with its anodic recycling at a graphite electrode.