41018-94-4

Basic information

• Product Name: 5-Chloro-3-Methyl-2-phenyl-1H-indole
• Synonyms: 5-Chloro-3-Methyl-2-phenyl-1H-indole
• CAS NO: 41018-94-4
• Molecular Formula: C₁₅H₁₂ClN
• Molecular Weight: 241.71548
• Mol File: 41018-94-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Chloro-3-Methyl-2-phenyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-3-Methyl-2-phenyl-1H-indole(41018-94-4)
• EPA Substance Registry System: 5-Chloro-3-Methyl-2-phenyl-1H-indole(41018-94-4)

Safety Data

• Hazardous Substances Data: 41018-94-4(Hazardous Substances Data)

Upstream product

• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 93-55-0 1-phenyl-propan-1-one 
• 100-42-5 styrene 
• 201230-82-2 carbon monoxide 
• 673-32-5 1-Phenylprop-1-yne 
• 62499-16-5 (E)-1-((4-chlorophenyl)diazenyl)pyrrolidine 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 106-47-8 4-chloro-aniline 
• 637-87-6 1-Chloro-4-iodobenzene 

Downstream Products

• 41019-23-2 benzoic acid-(2-acetyl-4-chloro-anilide) 

Relevant articles and documents

Synthesis of indolo[2,1-: A] isoquinoline derivatives via visible-light-induced radical cascade cyclization reactions

We describe a photocatalyzed transformation for the synthesis of the indolo[2,1-a]isoquinoline core structure. This redox neutral reaction features mild reaction conditions and exceptional functional group tolerance. A series of valuable indolo[2,1-a]isoquinoline derivatives bearing various functional groups were synthesized using this method in good to excellent yields.

Catalytic Asymmetric N-Alkylation of Indoles and Carbazoles through 1,6-Conjugate Addition of Aza-para-quinone Methides

Catalytic asymmetric N-alkylation of indoles and carbazoles represents a family of important but underdeveloped reactions. Herein, we describe a new organocatalytic strategy in which in situ generated aza-para-quinone methides are employed as the alkylating reagent. With the proper choice of a chiral phosphoric acid and an N-protective group, the intermolecular C?N bond formation with various indole and carbazole nucleophiles proceeded efficiently under mild conditions with excellent enantioselectivity and functional-group compatibility. Control experiments and kinetic studies provided important insight into the reaction mechanism.

General and efficient synthesis of indoles through triazene-directed c-h annulation

Unprotected indoles are prepared with the title method, which has a wide scope for alkynes. Excellent regioselectivity was accomplished for aryl-alkyl and alkyl-alkyl disubstituted acetylenes. This reaction features an unusual 1,2 rhodium migration and ring-contraction-triggered N-N bond cleavage. It allows rapid conversion of the reaction products into several functional molecules. Copyright