4150-37-2

Basic information

• Product Name: 4-ethyl-N,N-dimethylaniline
• Synonyms: N,N-Dimethyl-4-ethylaniline; N,N-Dimethyl-p-ethyl-aniline
• CAS NO: 4150-37-2
• Molecular Formula: C₁₀H₁₅N
• Molecular Weight: 149.2328
• Mol File: 4150-37-2.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 222.7°C at 760 mmHg
• Flash Point: 89.2°C
• Density: 0.931g/cm³
• Vapor Pressure: 0.1mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 4-ethyl-N,N-dimethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethyl-N,N-dimethylaniline(4150-37-2)
• EPA Substance Registry System: 4-ethyl-N,N-dimethylaniline(4150-37-2)

Safety Data

• Hazardous Substances Data: 4150-37-2(Hazardous Substances Data)

Upstream product

• 2039-80-7 N,N-dimethy-4-vinylaniline 
• 77-78-1 dimethyl sulfate 
• 589-16-2 4-aminoethylbenzene 
• 2124-31-4 4'-dimethylaminoacetophenone 
• 107-21-1 ethylene glycol 
• 121-69-7 N,N-dimethyl-aniline 
• 5338-94-3 1-[4-(N,N-dimethylamino)phenyl]ethanol 
• 103-69-5 N-ethyl-N-phenylamine 
• 512-56-1 trimethyl phosphite 
• 50-00-0 formaldehyd 
• 64-18-6 formic acid 
• 99-92-3 p-aminobenzophenone 
• 17687-47-7 mono-N-methylaminoacetophenone 
• 17573-94-3 4-ethynyl-N,N-dimethylaniline 

Downstream Products

• 93639-02-2 (4-Ethyl-2-nitro-phenyl)-dimethyl-amine 
• 1246620-99-4 C₂₆H₂₈N₂O₄S 
• 1179825-62-7 2-(((4-ethylphenyl)(methyl)amino)methyl)cyclohexan-1-one 
• 1179825-47-8 1-((4-ethylphenyl)(methyl)amino)-4,4-dimethylpentan-3-one 
• 1268830-97-2 3-(((4-ethylphenyl)(methyl)amino)methyl)indolizine-1-carbonitrile 
• 1268831-06-6 methyl 3-(((4-ethylphenyl)(methyl)amino)methyl)indolizine-1-carboxylate 
• 1346855-00-2 1-(2-(dimethylamino)-5-ethylphenyl)naphthalene-2-ol 
• 37846-06-3 N-Methyl-4-ethylaniline 

Relevant articles and documents

Mesoionic N-heterocyclic olefin catalysed reductive functionalization of CO2for consecutiveN-methylation of amines

A mesoionic N-heterocyclic olefin (mNHO) was introduced as a metal-free catalyst for the reductive functionalization of CO2leading to consecutive doubleN-methylation of primary amines in the presence of 9-borabicyclo[3.3.1]nonane (9-BBN). A wide range of secondary amines and primary amines were successfully methylated under mild conditions. The catalyst sustained over six successive cycles ofN-methylation of secondary amines without compromising its activity, which encouraged us to check its efficacy towards doubleN-methylation of primary amines. Moreover, this method was utilized for the synthesis of two commercially available drug molecules. A detailed mechanistic cycle was proposed by performing a series of control reactions along with the successful characterisation of active catalytic intermediates either by single-crystal X-ray study or by NMR spectroscopic studies in association with DFT calculations.

Preparation method of N-alkylated derivative of primary amine compound

The invention relates to a preparation method of an N-alkylated derivative of a primary amine compound. The method comprises the following steps: uniformly mixing a primary amine compound, an alcohol compound and a catalyst in a reactor, and heating to react for a period of time to generate an N-alkylated substituted tertiary amine compound; wherein the catalyst is a copper-cobalt bimetallic catalyst, and the carrier of the catalyst is Al2O3. According to the method, alcohol is adopted as an alkylating reagent and is low in price and easy to obtain, a byproduct is water, no pollution is caused to the environment, and the overall reaction atom economy is high; the catalyst is simple in preparation method, low in cost, high in reaction activity and good in structural stability; meanwhile, by using the copper-cobalt bimetallic catalyst, the use of strong base additives can be avoided, and the requirement on reaction equipment is low; and the reaction post-treatment is convenient, and the catalyst can be recycled and is environment-friendly.