406-95-1

Basic information

• Product Name: 2,2,2-TRIFLUOROETHYL ACETATE
• Synonyms: 2,2,2-TRIFLUOROETHYL ACETATE;Acetic acid 2,2,2-trifluoroethyl ester;2,2,2-Trifluoroethyl acetate 97%;2,2,2-Trifluoroethylacetate97%;2,2,2-Trifluoroethanol acetate;2-Acetoxy-1,1,1-trifluoroethane, 1-(2,2,2-Trifluoroethoxy)ethan-1-one, 2,2,2-Trifluoroethyl ethanoate;2,2,2-Trifluoroethyl ethanoate, Acetic acid 2,2,2-trifluoroethyl ester;Trifluoroethyl acetate
• CAS NO: 406-95-1
• Molecular Formula: C₄H₅F₃O₂
• Molecular Weight: 142.08
• EINECS: -0
• Mol File: 406-95-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 78 °C
• Flash Point: 11°C
• Appearance: /
• Density: 1,258 g/cm3
• Refractive Index: 1.3202
• Water Solubility: Soluble in water (16 g/L) (25°C)
• BRN: 1757502
• CAS DataBase Reference: 2,2,2-TRIFLUOROETHYL ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRIFLUOROETHYL ACETATE(406-95-1)
• EPA Substance Registry System: 2,2,2-TRIFLUOROETHYL ACETATE(406-95-1)

Safety Data

• Hazard Codes: F
• Statements: 11
• Safety Statements: 16-23-24/25
• RIDADR: 3272
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 406-95-1(Hazardous Substances Data)

Usage

Uses

2,2,2-Trifluoroethyl trifluoroacetate is used in the preparation of dimethyl (3,3,3-trifluoro-2,2-dihydroxypropyl)phosphonate

InChI:InChI=1/C4H5F3O2/c1-3(8)9-2-4(5,6)7/h2H2,1H3

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 830-03-5 4-nitrophenol acetate 
• 108-24-7 acetic anhydride 
• 87938-02-1 2,2,5-Trimethyl-5-(2,2,2-trifluoro-ethoxy)-2,5-dihydro-[1,3,4]oxadiazole 
• 64-19-7 acetic acid 
• 115981-45-8 methyl(2,2,2-trifluoro-ethoxo){1,2-bis(diphenylphosphino)ethane}palladium 
• 75-88-7 1,1,1-trifluoro-2-chloroethane 
• 127-08-2 potassium acetate 
• 75-36-5 acetyl chloride 
• 24265-37-0 2,2,2-trifluoroethoxide 
• 127-09-3 sodium acetate 

Downstream Products

• 43041-12-9 methyl (2R)-pyrrolidine-2-carboxylate 
• 2311-25-3 N-acetyl-L-proline methyl ester 
• 34557-54-5 methane 
• 99668-73-2 (trifluoroethoxo)tris(triphenylphosphine)cobalt(I) 
• 7727-37-9 nitrogen 
• 1333-74-0 hydrogen 
• 141-78-6 ethyl acetate 
• 67-64-1 acetone 
• 1096535-84-0 1-(2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)oxazol-4-yl)-2,2,2-trifluoroethanone 
• 143900-43-0 tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate 
• 143900-44-1 tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate 
• 85336-10-3 1,1,1-trifluoro-3-decyn-2-one 
• 58556-55-1 2-(4-hydroxyphenyl)ethyl acetate 
• 60037-43-6 2-(4-acetoxyphenyl)ethanol 

Relevant articles and documents

Imidazolium salt assisted hydrolysis of 1-chloro-2,2,2-trifluoroethane

The use of imidazolium-based ionic liquids as promoters was found to be highly effective for the hydrolysis reaction of CF3CH2Cl with aqueous potassium acetate to produce 2,2,2-trifluoroethanol (TFE). Among ionic liquids tested, 1-butyl-3-methylimidazoliu

EFFECT OF SOLVENT ON THE ESTERIFICATION BETWEEN 1,1,1-TRIFLUOROCHLORETHANE AND AKALINE ACETATE

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BF3·2CF3CH2OH (BF 3·2TFE), an efficient superacidic catalyst for some organic synthetic transformations

BF3 · 2CF3CH2OH complex was found to be a very effective superacidic catalyst comparable in acid strength to at least that of 100% anhydrous sulfuric acid for various acid-catalyzed organic transformations such as isomerizations, rearrangements, ionic hydrogenation of various ketones, and aromatics with triethylsilane and nitration of aromatics with metal nitrate. Studies of the pivalaldehyde-methyl isopropyl ketone rearrangement and the benzopinacol to phenanthrene transformation suggest that the complex has an acidity comparable to that of 100% anhydrous sulfuric acid. The structure and properties of the 1:2 boron trifluoride-trifluoroethanol complex have been further studied using NMR (1H, 13C, 19F, 11B) and DFT calculations at the B3LYP/6- 311++G**//B3LYP/6-31G* level.