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4358-86-5

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4358-86-5 Usage

General Description

DL-Mandelamide is a chemical compound with the molecular formula C8H9NO2. It is a white crystalline powder with a melting point of 160-162°C. DL-Mandelamide is used as a precursor in the synthesis of various pharmaceuticals and agricultural chemicals. It is also employed in the production of UV stabilizers, corrosion inhibitors, and dyes. Additionally, DL-Mandelamide has been studied for its potential use in the treatment of neurodegenerative diseases and as an ingredient in skin care products due to its moisturizing properties.

Check Digit Verification of cas no

The CAS Registry Mumber 4358-86-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,5 and 8 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4358-86:
(6*4)+(5*3)+(4*5)+(3*8)+(2*8)+(1*6)=105
105 % 10 = 5
So 4358-86-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO2/c9-8(11)7(10)6-4-2-1-3-5-6/h1-5,7,10H,(H2,9,11)

4358-86-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name DL-MANDELAMIDE

1.2 Other means of identification

Product number -
Other names MANDELAMIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4358-86-5 SDS

4358-86-5Relevant articles and documents

Hydration of Cyanohydrins by Highly Active Cationic Pt Catalysts: Mechanism and Scope

Li, Chengcheng,Chang, Xiao-Yong,Huo, Luqiong,Tan, Haibo,Xing, Xiangyou,Xu, Chen

, p. 8716 - 8726 (2021/07/26)

Cyanohydrins (α-hydroxy nitriles) are a special type of nitriles that readily decompose into hydrogen cyanide (HCN) and the corresponding carbonyl compounds. Hydration of cyanohydrins that are readily available through cyanation of aldehydes and ketones provides the most straightforward route to valuable α-hydroxyamides. However, due to low stability of cyanohydrins and deactivation of the catalysts by the released HCN, catalytic direct hydration of cyanohydrins still remains largely unsolved. As a general trend, cyanohydrins containing bulkier substituents, such as α,α-diaryl cyanohydrins, degrade more quickly and thus are more difficult to be hydrated. Here, we report development of cationic platinum catalysts that exhibit high reactivity for hydration of various cyanohydrins. Detailed mechanistic investigations for hydration of nitriles by (PμP)Pt(PR2OH)X(OTf) reveal a catalytic cycle involving the formation of a five-membered metallacyclic intermediate and subsequent hydrolysis via attacking on the phosphorus of the secondary phosphine oxide (PR2OH) ligand by H2O. We discovered that Pt catalyst A bearing the electron-rich, appropriately small-bite-angle bisphosphine ligand provides super reactivity for hydration of cyanohydrins. The hydration reactions catalyzed by A proceed at ambient temperatures and occur with a wide variety of cyanohydrins, including the most difficult α,α-diaryl cyanohydrins, with good turnover numbers.

Catalyst, preparation method thereof and preparation method of amide compound

-

Paragraph 0142-0146; 0147, (2020/01/12)

The invention relates to a catalyst, a preparation method thereof, and a preparation method for hydrating nitrile groups into amides. The catalyst is used for catalyzing nitrile groups to be hydratedinto amides, and the structural general formula of the catalyst is shown in the specification. In the formula, a plurality of R are respectively and independently ones selected from aromatic groups, heteroaromatic groups and non-aromatic ring groups; a plurality of R are ones respectively and independently selected from linear alkyl groups and alkane aromatic groups; X is one selected from Cl and Br; and L is one selected from OTf, BF4, PF6 and SbF6. The catalyst can catalyze nitrile groups to be hydrated into amides, and the nitrile groups can be catalyzed to be hydrated into amides even at a low temperature (20-80 DEG C); besides, compared with existing common catalysts for catalyzing nitrile groups to be hydrated into amides, the catalyst has the advantages that the equivalent weight of the catalyst can be obviously reduced, and nitrile groups can reach a relatively high conversion rate when the equivalent weight of the catalyst is only 0.01 mol%-0.5 mol%; and meanwhile, the catalyst is wider in application range and can catalyze various nitrile compounds to be hydrated into amide compounds.

Bifunctional organometallic catalysts for selective hydration of nitriles to amides

Singh, Kuldeep,Sarbajna, Abir,Bera, Jitendra K.

, p. 853 - 861 (2020/06/26)

In this report, we highlight our recent contributions towards the development of bifunctional catalysts for selective hydration of nitriles to amides.

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