4536-30-5

Usage

Uses

Used in the Cosmetics Industry:
2-(DODECYLOXY)ETHANOL is used as a solvent and emulsifier for its ability to dissolve both water and oil, making it an effective ingredient in the formulation of cosmetics and personal care products. It helps in creating a stable mixture of ingredients, ensuring a smooth and consistent texture.
Used in the Pharmaceutical Industry:
In the pharmaceutical industry, 2-(DODECYLOXY)ETHANOL is used as a solvent in the manufacturing of various drugs. Its solubility properties allow it to dissolve a wide range of active pharmaceutical ingredients, facilitating the production of medications with improved bioavailability and efficacy.
Used in the Chemical Industry:
2-(DODECYLOXY)ETHANOL is utilized as an intermediate in the synthesis of various chemicals, including surfactants, detergents, and lubricants. Its unique structure allows it to act as a building block for the creation of a diverse range of products with specific applications in different industries.
Used in the Textile Industry:
In the textile industry, 2-(DODECYLOXY)ETHANOL is used as a wetting agent and dispersing agent. Its ability to dissolve both water and oil makes it an effective component in the formulation of textile processing chemicals, such as dyeing and printing auxiliaries, which help in improving the quality and appearance of fabrics.
Used in the Paint and Coating Industry:
2-(DODECYLOXY)ETHANOL is employed as a solvent and coalescing agent in the paint and coating industry. Its solubility properties enable it to dissolve various components of paint formulations, while also promoting the proper coalescence of the film during the drying process, resulting in a smooth and uniform finish.
Used in the Agricultural Industry:
In the agricultural industry, 2-(DODECYLOXY)ETHANOL is used as an adjuvant in the formulation of agrochemicals, such as pesticides and herbicides. Its ability to improve the solubility and dispersion of active ingredients enhances the effectiveness of these products, leading to better crop protection and yield.

InChI:InChI=1/C14H30O2/c1-2-3-4-5-6-7-8-9-10-11-13-16-14-12-15/h15H,2-14H2,1H3

Upstream product

• 75-21-8 oxirane 
• 112-53-8 1-dodecyl alcohol 
• 151-21-3 sodium dodecyl-sulfate 
• 107-21-1 ethylene glycol 
• 115502-59-5 Dodecyloxy-acetic acid methyl ester 
• 143-15-7 1-dodecylbromide 
• 112-41-4 1-dodecene 
• 1310-73-2 sodium hydroxide 
• 67-56-1 methanol 
• 4292-19-7 1-Iodododecane 
• 765-14-0 1-(vinyloxy)dodecane 
• 107-13-1 acrylonitrile 
• 96-49-1 [1,3]-dioxolan-2-one 
• 112-72-1 1-Tetradecanol 

Downstream Products

• 3055-93-4 diethylene glycol monododecyl ether 
• 22606-46-8 acetic acid-(2-dodecyloxy-ethyl ester) 
• 20858-23-5 (2-Dodecyloxy-ethoxy)-acetic acid 
• 15826-16-1 sodium dodecyl ethoxy sulfate 
• 1027219-55-1 2-dodecyloxyethyl-4-methylbenzenesulfonate 
• 3282-73-3 N,N-didodecyl-N,N-dimethylammonium bromide 
• 112-18-5 N,N-dimethylaminododecane 
• 22732-79-2 2-bromoethyl n-dodecyl ether 
• 143-15-7 1-dodecylbromide 
• 139-07-1 zephirol 
• 90730-03-3 N-(ω-benzyloxyethyl)-N-dodecyl-N,N-dimethylammonium chloride 
• 683-10-3 carboxymethyl-dodecyl-dimethyl-ammonium betaine 
• 22870-18-4 13,16-dioxaoctacosane 
• 18913-04-7 ethylene glycol monononyl ether 

Relevant academic research and scientific papers

METHODS OF ETHERIFICATION

Embodiments of the present disclosure are directed towards methods of etherification including reducing templates of a zeolite catalyst to provide a reduced template zeolite catalyst having from 3 to 15 weight percent weight percent of templates maintained following calcination of zeolite catalyst; and contacting the reduced template zeolite catalyst with an olefin and an alcohol to produce a monoalkyl ether.

Two Types of Cross-Coupling Reactions between Electron-Rich and Electron-Deficient Alkenes Assisted by Nucleophilic Addition Using an Organic Photoredox Catalyst

Two types of photoreactions between electronically differentiated donor and acceptor alkenes assisted by nucleophilic addition using an organic photoredox catalyst efficiently afforded 1:1 or 2:1 cross-coupling adducts. A variety of alkenes and alcohols were employed in the photoreaction. Control of the reaction pathway (i.e., the formation of the 1:1 or 2:1 adduct) was achieved by varying the concentration of the alcohol used. Detailed mechanistic studies suggested that the organic photoredox catalyst acts as an effective electron mediator to promote the formation of the cross-coupling adducts.

Synthesis and SAR studies of neuritogenic gentiside derivatives

Tetradecyl 2,3-dihydroxybenzoate (ABG-001) has been designed and synthesised as a lead compound to treat Alzheimer's disease, based on structure-activity relationships of gentisides. In this paper, the alkyl chain and ester linkage group of ABG-001 were modified. Consequently, several series of novel gentiside derivatives were designed and synthesised, and their neuritogenic activity was evaluated in PC12 cells. Among all the tested compounds, S-dodecyl 2,3-dihydroxybenzothioate (15d, named as ABG-199) was the most potent; the compound induced significant neurite outgrowth at 0.1 μM, which was comparable to that of nerve growth factor at the optimal concentration of 40 ng/mL and ABG-001 at 1 μM. A brief study on the mechanism of action of ABG-199 revealed that extracellular signal-regulated kinase phosphorylation was involved in ABG-199-induced neurite outgrowth in PC12 cells.

METHOD FOR PREPARING GLYCEROL ETHER AND GLYCOL ETHER

The present invention concerns a method for preparing glycerol ether or glycol ether comprising the reaction of a compound of formula (II) with a compound of formula (III) in the presence of a heterogeneous acid catalyst of formulas (II) and (III).

AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC AND ANTICANCER ACTIVITY

Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.

Synthesis of some acyclic quaternary ammonium compounds. Alkylation of secondary and tertiary amines in a two-phase system

A series of acyclic symmetrical and asymmetrical quaternary ammonium chlorides of the general formula R1R2R3N+AR4Cl- (R1 = Me, Bu; R2 = n-C12H25, PhCH2, C n H2n+1(OCH2CH2) m, n = 9 and 12, m = 1 and 2; R3 = n-C12H25, PhCH2, HOCH2CH2,-OOCCH2; R4 = n-C12H25, PhCH2; A = (CH2CH2O)1,2, CH2C(O)O) was synthesized by the alkylation of tertiary amines in a two-phase system containing water. A convenient method for the synthesis of the initial symmetrical and asymmetrical tertiary amines of the general formula MeNR1R2 (R1 = Me, Bu; R2 = n-C12H25, PhCH2, CnH2n+1(OCH2CH2) m, n = 9 and 12, m = 1 and 2) in an organic phase-aqueous phase heterogeneous system, which allows the use of aqueous solutions of alkali and amines, was developed. The improved method for the preparation of intermediate ethylene glycol and diethylene glycol monoethers is monoalkylation of glycols in dioxane using solid KOH in a two-phase system.

PHOSPHOLIPID-DETERGENT CONJUGATES AND USES THEREOF

The invention relates to novel compounds, in particular novel O-substituted phospholipids that are useful for the in vitro and in vivo delivery of drugs as well as nucleic acids into cells. The invention also relates to pharmaceutical compositions and supramolecular complexes comprising said compounds and the use of these compounds in therapeutic treatment, in particular in gene therapy.

Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase

N-Acylethanolamines (NAEs) including N-arachidonoylethanolamine (anandamide) and N-palmitoylethanolamine are endogenous lipid mediators. These molecules are degraded to the corresponding fatty acids and ethanolamine by fatty acid amide hydrolase (FAAH) or NAE-hydrolyzing acid amidase (NAAA). Lipophilic amines, especially pentadecylamine (2c) and tridecyl 2-aminoacetate (11b), were found to exhibit potent NAAA inhibitory activities (IC50 = 5.7 and 11.8 μM), with much weaker effects on FAAH. These simple structures would provide a scaffold for further improvement in NAAA inhibitory activity.

Combinatorial synthesis of PEG oligomer libraries

A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.

Method for carrying out reactions characterized by an equilibrium

The invention relates to a process for conducting a chemical reaction characterized by an equilibrium in a reaction system designed as a loop reactor, said loop reactor comprising a reactor vessel (1), at least one loop connected to said reactor vessel (1) each by means of an outlet and an inlet, said loop comprising means (3) for pumping over a fluid reaction material, at least one he exchanger (4), optionally means (5) for feeding said reaction material into Me reactor vessel (1) and a separate gas loop (8) which is connected to the gas space of the reactor vessel (1) above the reaction mixture and has separate means for feeding a gas into the gas loop (8), for withdrawing gas from the gas loop (8) and/or for treating said gas circulating in the gas loop (8), said process comprising the steps of circulating and/or treating said gas in said gas loop (8), feeding said gas into the reactor vessel (1) for influencing the equilibrium of a reaction conducted in said reactor vessel (1) and being characterized by the equilibrium and, after influencing said equilibrium reaction conducted in said reactor vessel (1), exhausting said gas from said reactor vessel (1) into the gas loop (8).