4703-95-1Relevant academic research and scientific papers
NOVEL COMPOUND AS MTOR INHIBITOR AND USE THEREOF
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Paragraph 0063; 0095, (2021/03/04)
The present invention relates to a novel compound as an mTOR inhibitor and a use thereof and, more specifically, to a novel compound represented by formula 1 that exhibits mTOR inhibitory activity and a pharmaceutical composition comprising same as an act
Development of novel rhodanine analogs as anticancer agents: Design, synthesis, evaluation and comsia study
Krithika, Uma,Prabitha,Mandal, Subhankar P.,Yuvaraj,Priya,Wadhwani, Ashish D.,Prashantha Kumar
, p. 216 - 229 (2021/03/03)
Background: A series of novel 5-substituted benzylidene rhodanine derivatives using four different amines were designed based on our previously developed CoMSIA (Comparative molecular similarity indices analysis) model for the anticancer activity. Method:
Synthesis and Antitumor Activity of New 5-Ylidene Derivatives of 3-(Furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one
Horishny, V. Ya.,Matiychuk, V. S.
, p. 1600 - 1605 (2020/10/22)
Abstract: Reactions of 3-(furan-2-ylmethyl)-2-sulfanyidene-1,3-thiazolidin-4-one with aromatic and heterocyclic aldehydes afforded a series of previously unknown 5-[(het)arylmethylidene]-3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-ones. Treatment of 3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one with thionyl chloride gave in a good yield 3,3′-bis(furan-2-ylmethyl)-2,2′-disulfanylidene-5,5′-bi-1,3-thiazolidinylidene-4,4′-dione which was reduced with zinc in acetic acid to 3,3′-bis(furan-2-ylmethyl)-2,2′-disulfanylidene-5,5′-bi-1,3-thiazolidine-4,4′-dione. The synthesized compounds were screened for antitumor activity.
A concise approach to n-substituted rhodanines through a base-assisted one-pot coupling and cyclization process
Huo, Zhipeng,Liang, Yongxi,Sun, Xun,Tang, Mei-Lin,Zhang, Chenchen
, (2020/03/17)
An efficient approach to obtain functionalized rhodanines was developed through a base-assisted one-pot coupling and continuous cyclization of a primary amine, carbon disulfide, and methyl (2-chloroacetyl)carbamate. This conversion tolerates a broad range of functional groups and can be used to scale the preparation of N-substituted rhodanines in excellent yields.
A facile synthesis of novel 3-(aryl/alkyl-2-ylmethyl)-2-thioxothiazolidin- 4-ones using microwave heating
Kamila, Sukanta,Ankati, Haribabu,Harry, Emily,Biehl, Edward R.
supporting information; experimental part, p. 2195 - 2198 (2012/05/20)
(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-(aryl/alkyl-2-ylmethyl) -2-thioxothiazolidin-4-ones (7a-w) have been synthesized by the Knoevenagel condensation reaction of 3-(aryl/alkyl-2-ylmethyl)-2-thioxothiazolidin-4-ones (3a-d) with suitably substituted 2-(1H-indol-3-yl)2-oxoacetaldehydes (6a-g) under microwave conditions. The thioxothiazolidin-4-ones were prepared from the corresponding aryl/alkyl amines (1a-d) and di-(carboxymethyl)-trithiocarbonyl (2). The aldehydes (6a-g) were synthesized from the corresponding acid chlorides (5a-g) using HsnBu3.
Electrogenerated base-promoted synthesis of N-benzylic rhodanine and carbamodithioate derivatives
Tissaoui, Khalil,Raouafi, Noureddine,Boujlel, Khaled
experimental part, p. 41 - 48 (2010/10/03)
Electrogenerated magnesium-associated cyanomethyl anions/bases obtained from the electrochemical reduction of acetonitrile and the oxidation of a sacrificial magnesium rod were successfully used to promote the addition of carbon disulfide to primary benzylic amines. Alkylation with ethyl 3-bromopropionate acid ester or with ethyl 2-bromoacetate acid ester yields the corresponding ring-opened carbamodithioate compounds or cyclic rhodanine derivatives, respectively. The effect of the amount of electrogenerated base on the yield of reaction was also evaluated.
REACTION OF CHLOROACETYL CHLORIDE WITH THE SALTS OF N-ALKYL(ARYL)DITHIOCARBAMIC ACIDS - A CONVENIENT METHOD FOR THE SYNTHESIS OF 3-SUBSTITUTED RHODANINES
Krus, K.,Masias, A.,Beletskaya, I. P.
, p. 1824 - 1825 (2007/10/02)
Rhodanine and its 3-substituted derivatives are readily obtained in the reaction of monochloroacetyl chloride with the ammonium salts of N-substituted dithiocarbamic acids.A possible reaction mechanism, involving S -> N-acyl migration, is discussed.
