4703-95-1

Basic information

• Product Name: 3-(2-furylmethyl)-2-sulfanylidene-thiazolidin-4-one
• Synonyms: 3-(2-furylmethyl)-2-sulfanylidene-thiazolidin-4-one;3-FURFURYL-RHODANINE;3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one
• CAS NO: 4703-95-1
• Molecular Formula: C8H7NO2S2
• Molecular Weight: 213.28
• Mol File: 4703-95-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 331°Cat760mmHg
• Flash Point: 154°C
• Appearance: /
• Density: 1.49g/cm³
• Vapor Pressure: 0.000161mmHg at 25°C
• Refractive Index: 1.697
• CAS DataBase Reference: 3-(2-furylmethyl)-2-sulfanylidene-thiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-furylmethyl)-2-sulfanylidene-thiazolidin-4-one(4703-95-1)
• EPA Substance Registry System: 3-(2-furylmethyl)-2-sulfanylidene-thiazolidin-4-one(4703-95-1)

Safety Data

• Hazardous Substances Data: 4703-95-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H7NO2S2/c10-7-5-13-8(12)9(7)4-6-2-1-3-11-6/h1-3H,4-5H2

Upstream product

• 617-89-0 furan-2-ylmethanamine 
• 3926-62-3 sodium monochloroacetic acid 
• 75-15-0 carbon disulfide 
• 105-36-2 ethyl bromoacetate 
• 6326-83-6 bis(carboxymethyl)trithiocarbonate 
• 78194-82-8 Furan-2-ylmethyl-dithiocarbamic acid; compound with ammonia 
• 79-11-8 chloroacetic acid 
• 13558-70-8 methyl N-(chloroacetyl)carbamate 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1370635-11-2 (Z)-5-(2-(5-chloro-1H-indol-3-yl)-2-oxoethylidene)-3-(furan-2-ylmethyl)-2-thioxothiazolidin-4-one 
• 1621417-83-1 3-furan-2-ylmethyl-5-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-ylmethylene]-2-thioxothiazolidin-4-one 
• 1621417-84-2 5-[3,5-bis-(4-methoxyphenyl)-4,5-dihydropyrazol-1-ylmethylene]-3-furan-2-ylmethyl-2-thioxothiazolidin-4-one 
• 1621417-85-3 3-furan-2-ylmethyl-5-[5-(4-methoxyphenyl)-3-naphthalen-2-yl-4,5-dihydropyrazol-1-ylmethylene]-2-thioxothiazolidin-4-one 
• 13788-25-5 5-benzylidene-3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one 
• 13788-24-4 (Z)-5-(2-hydroxybenzylidene)-3-((furan-2-yl)methyl)-2-thioxothiazolidin-4-one 
• 1403891-65-5 C₁₇H₁₁ClN₂O₃S₂ 

Relevant articles and documents

Development of novel rhodanine analogs as anticancer agents: Design, synthesis, evaluation and comsia study

Background: A series of novel 5-substituted benzylidene rhodanine derivatives using four different amines were designed based on our previously developed CoMSIA (Comparative molecular similarity indices analysis) model for the anticancer activity. Method:

Synthesis and Antitumor Activity of New 5-Ylidene Derivatives of 3-(Furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one

Abstract: Reactions of 3-(furan-2-ylmethyl)-2-sulfanyidene-1,3-thiazolidin-4-one with aromatic and heterocyclic aldehydes afforded a series of previously unknown 5-[(het)arylmethylidene]-3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-ones. Treatment of 3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one with thionyl chloride gave in a good yield 3,3′-bis(furan-2-ylmethyl)-2,2′-disulfanylidene-5,5′-bi-1,3-thiazolidinylidene-4,4′-dione which was reduced with zinc in acetic acid to 3,3′-bis(furan-2-ylmethyl)-2,2′-disulfanylidene-5,5′-bi-1,3-thiazolidine-4,4′-dione. The synthesized compounds were screened for antitumor activity.

A facile synthesis of novel 3-(aryl/alkyl-2-ylmethyl)-2-thioxothiazolidin- 4-ones using microwave heating

(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-(aryl/alkyl-2-ylmethyl) -2-thioxothiazolidin-4-ones (7a-w) have been synthesized by the Knoevenagel condensation reaction of 3-(aryl/alkyl-2-ylmethyl)-2-thioxothiazolidin-4-ones (3a-d) with suitably substituted 2-(1H-indol-3-yl)2-oxoacetaldehydes (6a-g) under microwave conditions. The thioxothiazolidin-4-ones were prepared from the corresponding aryl/alkyl amines (1a-d) and di-(carboxymethyl)-trithiocarbonyl (2). The aldehydes (6a-g) were synthesized from the corresponding acid chlorides (5a-g) using HsnBu3.