521-39-1

Usage

Uses

Used in Pharmaceutical Industry:
1,3-dihydro-1,4,10-trihydroxy-5-(hydroxymethyl)-8-methyl-3,7-dioxo-7H-isobenzofuro[4,5-b][1,4]benzodioxepin-11-carbaldehyde is used as a pharmaceutical candidate for its potential medicinal properties. 1,3-dihydro-1,4,10-trihydroxy-5-(hydroxymethyl)-8-methyl-3,7-dioxo-7H-isobenzofuro[4,5-b][1,4]benzodioxepin-11-carbaldehyde's structure and functional groups may contribute to its ability to interact with biological targets, making it a promising candidate for the development of new drugs.
Used in Organic Synthesis:
In the field of organic synthesis, 1,3-dihydro-1,4,10-trihydroxy-5-(hydroxymethyl)-8-methyl-3,7-dioxo-7H-isobenzofuro[4,5-b][1,4]benzodioxepin-11-carbaldehyde is used as a key intermediate or building block for the synthesis of more complex organic molecules. Its reactive aldehyde and hydroxyl groups can be utilized in various chemical reactions, such as condensation, oxidation, or reduction, to form a wide range of compounds with diverse applications.
Used in Chemical Research:
1,3-dihydro-1,4,10-trihydroxy-5-(hydroxymethyl)-8-methyl-3,7-dioxo-7H-isobenzofuro[4,5-b][1,4]benzodioxepin-11-carbaldehyde is also used in chemical research to study its properties and reactivity. Researchers may investigate its behavior in different reaction conditions, its potential as a catalyst, or its ability to form stable complexes with other molecules. This research can contribute to a deeper understanding of organic chemistry and the development of new synthetic methods or applications.

Synthetic route

diazomethane (186581-53-3, 908094-01-9) + salazinic acid (521-39-1) → 4,10-dihydroxy-5-hydroxymethyl-1-methoxy-8-methyl-3,7-dioxo-1,3-dihydro-7H-benzo[5,6][1,4]dioxepino[3,2-e]isobenzofuran-11-carbaldehyde (107928-67-6)

Conditions	Yield
With diethyl ether; acetone

Methyl 3-aminobenzoate (4518-10-9) + salazinic acid (521-39-1) → 3,8-dihydroxy-9-hydroxymethyl-4,6-bis-[(3-methoxycarbonyl-phenylimino)-methyl]-1-methyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-7-carboxylic acid (124118-20-3)

Conditions	Yield
With acetone

salazinic acid (521-39-1) + ethanol (64-17-5) → 8',9'-di-O-ethylsalazinic acid (93078-73-0)

salazinic acid (521-39-1) → atranol (526-37-4)

salazinic acid (521-39-1) → 6-formyl-3,8-dihydroxy-1,4,9-trimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-7-carboxylic acid

Conditions	Yield
With palladium on activated charcoal; acetic acid Hydrogenation;

salazinic acid (521-39-1) → 4,6-diformyl-3,8-dihydroxy-9-hydroxymethyl-1-methyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-7-carboxylic acid ; potassium salt

Conditions	Yield
With potassium hydroxide; potassium carbonate

salazinic acid (521-39-1) + acetic anhydride (108-24-7) → salazinaric acid

salazinic acid (521-39-1) + acetic acid (64-19-7) → 9-acetoxymethyl-4,6-diformyl-3,8-dihydroxy-1-methyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-7-carboxylic acid

Conditions	Yield
With N,N-dimethyl-formamide

salazinic acid (521-39-1) + aniline (62-53-3) → 3,8-dihydroxy-9-hydroxymethyl-1-methyl-11-oxo-4,6-bis-(phenylimino-methyl)-11H-dibenzo[b,e][1,4]dioxepin-7-carboxylic acid

Conditions	Yield
With acetone

salazinic acid (521-39-1) + phenylhydrazine (100-63-0) + acetone (67-64-1) → 3,8-dihydroxy-9-hydroxymethyl-1-methyl-11-oxo-4,6-bis-(phenylhydrazono-methyl)-11H-dibenzo[b,e][1,4]dioxepin-7-carboxylic acid

salazinic acid (521-39-1) + methyl iodide (74-88-4) → 1,4,10-trimethoxy-5-methoxymethyl-8-methyl-3,7-dioxo-1,3-dihydro-7H-benzo[5,6][1,4]dioxepino[3,2-e]isobenzofuran-11-carbaldehyde

Conditions	Yield
With acetone; silver(l) oxide
With acetone; silver carbonate

methanol (67-56-1) + salazinic acid (521-39-1) → 8',9'-di-O-methylsalazinic acid

Conditions	Yield
for 20h; Heating;	5 mg

salazinic acid (521-39-1) + ethanol (64-17-5) → 8',9'-di-O-ethylsalazinic acid (93078-73-0) + 8'-O-ethylsalazinic acid + 9'-O-ethylsalazinic acid

Conditions	Yield
for 26h; Heating;	A 0.345 g B n/a C n/a

salazinic acid (521-39-1) → consalazinic acid

Conditions	Yield
With hydrogen; platinum(IV) oxide In ethanol for 6h; Ambient temperature;

salazinic acid (521-39-1) + tert-butyl alcohol (75-65-0) → 9'-O-t-butylsalazinic acid

Conditions	Yield
for 12h; Heating;	0.105 g

salazinic acid (521-39-1) → chalybaeizanic acid

Conditions	Yield
With dipyridinium dichromate In N,N-dimethyl-formamide at 0℃; for 1h; Oxidation;

salazinic acid (521-39-1) → 4,2'-di-O-acetyl-8',9'-di-O-ethylsalazinic acid

Conditions	Yield
Multi-step reaction with 2 steps 1: 0.345 g / 26 h / Heating 2: pyridine / 24 h / 20 °C View Scheme

salazinic acid (521-39-1) → 6-formyl-3,8-dihydroxy-1,4,9-trimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-7-carboxylic acid methyl ester

Conditions	Yield
Multi-step reaction with 2 steps 1: acetone; diethyl ether 2: palladium/charcoal; acetic acid / Hydrogenation View Scheme

propan-1-ol (71-23-8) + salazinic acid (521-39-1) → 8',9'-di-O-n-propylsalazinicacid (1186048-04-3)

Conditions	Yield
at 90℃;

salazinic acid (521-39-1) + pentan-1-ol (71-41-0) → 8',9'-di-O-n-pentyl salazinicacid (1186048-07-6)

Conditions	Yield
at 90℃;

salazinic acid (521-39-1) + isopropyl alcohol (67-63-0) → 8',9'-di-O-iso-propylsalazinicacid (1186048-05-4)

Conditions	Yield
Reflux;

salazinic acid (521-39-1) + butan-1-ol (71-36-3) → 8',9'-di-O-n-butyl salazinicacid (1186048-06-5)

Conditions	Yield
at 90℃;

salazinic acid (521-39-1) + hexan-1-ol (111-27-3) → 8',9'-di-O-n-hexylsalazinicacid (1186048-08-7)

Conditions	Yield
at 90℃;

Downstream Products

• 124118-20-3 3,8-dihydroxy-9-hydroxymethyl-4,6-bis-[(3-methoxycarbonyl-phenylimino)-methyl]-1-methyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-7-carboxylic acid 
• 526-37-4 atranol