5543-98-6

Usage

Uses

Used in Photoinitiator Applications:
2-(4-Hydroxyphenyl)-1,2-diphenyl-ethanone is used as a photoinitiator in the curing of hexanediol diacrylate. It is an effective initiator for the polymerization process, promoting the formation of cross-linked networks in the material. This application is particularly useful in the production of coatings, adhesives, and other polymer-based materials, where rapid curing and high performance are required.
Used in Pharmaceutical Industry:
2-(4-Hydroxyphenyl)-1,2-diphenyl-ethanone serves as an intermediate in the preparation of clomiphene and tamoxifen analogs. Clomiphene and tamoxifen are selective estrogen receptor modulators (SERMs) that are used in the treatment of various medical conditions, including infertility and breast cancer. Benzophenone-4 plays a crucial role in the synthesis of these pharmaceutical compounds, contributing to their development and therapeutic potential.

Upstream product

• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 108-95-2 phenol 
• 6652-29-5 2-phenoxy-1,2-diphenylethanone 
• 5543-97-5 2-(4-methoxyphenyl)-1,2-diphenylethan-1-one 
• 451-40-1 phenyl benzyl ketone 
• 540-38-5 p-Iodophenol 
• 100-66-3 methoxybenzene 

Downstream Products

• 153777-85-6 2-(4-β-chloroethoxyphenyl)-1,2-diphenyl-ethan-1-one 
• 151835-01-7 2-(4-benzyloxyphenyl)-1,2-diphenyl-ethan-1-one 
• 90421-44-6 2-[4-(2-Oxo-1,2-diphenyl-ethoxy)-phenyl]-1,2-diphenyl-ethanone 
• 101-53-1 p-benzylphenol 
• 65-85-0 benzoic acid 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 108-95-2 phenol 
• 69967-79-9 ICI 77949 
• 97818-83-2 chloro-tam 
• 153777-92-5 (R,S)-1-(4-benzyloxyphenyl)-1,2-diphenyl-butan-2-ol 
• 153777-86-7 (trans)-1-chloro-2-(4-β-chloroethoxyphenyl)-1,2-diphenylethene 
• 90421-45-7 2-(2,3-Diphenyl-benzofuran-5-yl)-1,2-diphenyl-ethanone 
• 68684-63-9 1-(4-hydroxyphenyl)-1,2-diphenylbut-1-ene 
• 1443223-61-7 C₂₂H₂₀O 

Relevant academic research and scientific papers

PROCESS FOR CREATING CARBON-CARBON BONDS USING CARBONYL COMPOUNDS

The present invention concerns a process for preparing a compound of formula (I) by reaction between a compound of formula (II) and a compound of formula (III) in the presence of a copper-containing catalyst, a ligand and base. The invention also concerns the implementing of this process for the preparation of building blocks to prepare molecules of interest in particular in the pharmaceutical, agro-chemical fields, etc.

Direct copper-catalyzed α-arylation of benzyl phenyl ketones with aryl iodides: Route towards tamoxifen

No activation needed: The first efficient method for direct α-arylation of non-activated or non-protected family of enolizable ketones with simple aryl iodides employs a catalytic copper system. The method shows potential for the easy and step-economical synthesis of tamoxifen, the most commonly administrated drug for the management of breast cancer. R, R′, R′′ = electron-donating or electron-withdrawing groups. Copyright

Reaction of pyrylium salts with nucleophiles. 23: Triarylethene derivatives containing an oxyalkyleneamino or oxyalkylene-N-pyridinium side chain

A synthetic design was devised for preparing primary amines related to anticancer drugs clomiphene and tamoxifen on the basis of key intermediates with a phenolic group, to which a side chain (ω-aminoethoxy or ω- aminopropoxy) was attached. These compound

Mise en evidence d'un ion acylcarbenium intermediaire lors de la cyclodeshydratation de la diphenyl-1,2 phenoxy-2 ethanone

Many of the methods for synthesizing derivatives of 2,3-diaryl benzofurans imply cyclodehydration of 1,2-diaryl 2-phenoxyethanone derivatives, leading often to a mixture of two isomers which differ by the presence of the aryl substituent at positions C-2