57303-46-5

Upstream product

• 100-52-7 benzaldehyde 
• 89-25-8 edaravone 
• 23901-60-2 4-benzylidene-3-methyl-1-phenylpyrazolone 
• 942-32-5 5-methyl-2-phenyl-2H-pyrazol-3-ol 
• 53316-57-7 6-amino-1,4-dihydro-3-methyl-1,4-diphenylpyrano[2,3-c]pyrazole-5-carbonitrile 
• 75-15-0 carbon disulfide 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 141-97-9 ethyl acetoacetate 
• 100-63-0 phenylhydrazine 
• 105-45-3 acetoacetic acid methyl ester 
• 1137-96-8 N-(benzylidene)aniline N-oxide 
• 110-89-4 piperidine 
• 27420-41-3 2-hydroxy-4H-pyrido<1,2-a>pyrimidin-4-one 
• 4005-51-0 [1,3,4]Thiadiazol-2-ylamin 

Downstream Products

• 23901-60-2 4-benzylidene-3-methyl-1-phenylpyrazolone 
• 942-32-5 5-methyl-2-phenyl-2H-pyrazol-3-ol 

Relevant academic research and scientific papers

Synthesis of some new fused and binary 1,3,4-thiadiazoles as potential antitumor and antioxidant agents

Annulations of 2-amino-1,3,4-thiadiazole (1) with α,β- unsaturated carbonyl compounds 2, 5, and 9 afforded thiadiazolo[3,2-a]pyrimidin 3, benzamide 7, and bis-pyrazole derivative 11. Cyclization of benzamide 7 with POCl3 gave binary imidazole derivative 8. Moreover, alkylation of 1 with 2-bromo-1-(2H-chromen-3-yl) ethanone (9) followed by cyclization gave imidazo[2,1-b]-1,3,4-thiadiazole derivative 15. Multicomponent reaction of 1 with heterocyclic and/or aromatic aldehyde and thioglycolic acid afforded the corresponding thiazolidinones 17 and 19. Finally, a one-pot synthesis of 1 with isatin and thiosemicarbazide furnished the spirotriazole 20. The newly synthesized compounds were evaluated as antitumor agents.

In situ decorated Mn–lysine complex on magnetic nanoparticles as a novel and reusable nanocatalyst in the synthesis of 4,4′-(arylmethylene)-bis-(3-methyl-1-phenyl-1H-pyrazol-5-ols) derivatives

In this work, we report a new and recoverable catalyst by anchoring the Mn–Lysine complex on the surface of CoFe2O4 magnetic nanoparticles through a simple, rapid and eco-friendly procedure. The successful synthesis of this nanostruc

Synthesis and evaluation of biological activities of bis(Spiropyrazolone)cyclopropanes: A potential application against Leishmaniasis

This work focuses on the search and development of drugs that may become new alternatives to the commercial drugs currently available for treatment of leishmaniasis. We have designed and synthesized 12 derivatives of bis(spiropyrazolone)cyclopropanes. We

Synthesis of sulfonated melamine-functionalized Fe3O4@SiO2@Si–(CH2)3@melamine nanoparticles and its application in the synthesis of 4,4’-(aryl methylene)bis(3-methyl-1H-pyrazol-5-ol)s and hexahydroqui

In this work, sulfonated melamine-functionalized Fe3O4@SiO2@Si-(CH2)3@melamine nanoparticles were prepared through a simple approach and characterized by energy dispersive X-ray analysis (EDX), field

Zirconium@guanine@MCM-41 nanoparticles: An efficient heterogeneous mesoporous nanocatalyst for one-pot, multi-component tandem Knoevenagel condensation–Michael addition–cyclization Reactions

MCM-41-supported nanoscale guanine bonded with Zr (IV) was prepared using sol–gel method and characterized by FT-IR, Raman, XRD, BET, TGA, EDX, ICP, AAS, X-Ray mapping, SEM and TEM techniques. This compound was employed as an efficient, chemoselectivity a

Guanine-La complex supported onto SBA-15: A novel efficient heterogeneous mesoporous nanocatalyst for one-pot, multi-component Tandem Knoevenagel condensation–Michael addition–cyclization Reactions

In this work, we present a simple, environmentally-friendly and economical route for the preparation of a novel lanthanum (III) organometallic complex immobilized onto a highly stable mesoporous silica SBA-15 (La-guanine@SBA-15) using an inexpensive and s

Pd(0)-guanidine?MCM-41: a very effective catalyst for rapid production of bis (pyrazolyl)methanes

In this research, a rapid, green and efficient protocol for synthesis of bis (pyrazolyl)methane derivatives in the presence of Pd(0)-guanidine?MCM-41 catalysts under solvent-free conditions by the following two methods has been reported: (i) via the one-p

Chitosan-SO3H (CTSA) an efficient and biodegradable polymeric catalyst for the synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) and α-amidoalkyl-β-naphthol’s

An efficient, green procedure for the synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) and α-amidoalkyl-β-naphthol’s using biodegradable polymeric catalyst chitosan-SO3H (CTSA), is operationally easy to prepare by mixing chitosan and chlor

Ascorbic Acid as an Eco-friendly Catalyst for the Effcient Synthesis of Bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) in Aqueous Media

One-pot, multi-component reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (1) and aryl aldehydes 2 or 5-substituted indoline-2,3-diones (4a-c) in the presence of ascorbic acid as a unique catalyst in aqueous media afforded the 4, 4’-(arylmethylene)-bis(

Synthesis of a new Ni complex supported on CoFe2O4 and its application as an efficient and green catalyst for the synthesis of bis(pyrazolyl)methane and polyhydroquinoline derivatives

Effective research in green chemistry requires new and applicable synthetic techniques. In this regard, for the first time, a green method is reported for the immobilization of iminodiacetic acid-Ni complex on the surface of CoFe2O4