6301-56-0Relevant articles and documents
Palladium phosphine complex catalysts immobilized on silica via a tripodal linker unit for the Suzuki-Miyaura coupling reactions of aryl chlorides
Fukaya, Norihisa,Onozawa, Syun-Ya,Ueda, Masae,Miyaji, Takayuki,Takagi, Yukio,Sakakura, Toshiyasu,Yasuda, Hiroyuki
, p. 7 - 12 (2014)
Silica-immobilized palladium phosphine complex catalysts bearing a tripodal linker unit were tested for their ability to facilitate the Suzuki-Miyaura coupling reactions of aryl chlorides. The catalyst containing the tripodal linker with a trimethylsilyl capping group on the residual surface silanol groups displayed better catalytic activities and lower palladium and phosphorus leaching levels than the catalysts bearing a conventional trialkoxy-type linker.
Synthesis of Pd/SiO2 nanobeads for use in suzuki coupling reactions by reverse micelle sol-gel process
Kim, Mijong,Heo, Eunjung,Kim, Aram,Park, Ji Chan,Song, Hyunjoon,Park, Kang Hyun
, p. 588 - 593 (2012)
Pd/SiO2 nanobeads containing tiny Pd clusters with a diameter of about 2 nm were prepared via a sol-gel process for SiO2 by using a water-in-oil microemulsion with Pd complexes and subsequent hydrogen reduction by heat treatment. The Pd/SiO2 nanostructures were employed in Suzuki coupling reactions with various substrates, and they served as good catalysts in these reactions.
Heterogeneous High-Loading Hyperbranched Polyglycidol with Peripheral NHC–Pd Complex: Synthesis and Application as Catalyst in Suzuki Coupling Reaction
Anjali,Sreekumar
, p. 1952 - 1964 (2019)
Abstract: A new polymer-supported highly functionalized dendritic polyether with peripheral NHC–Pd complex was developed by the simple anionic ring opening polymerization of glycidol on bis(3-hydroxypropyl) amine grafted Merrifield resin and its subsequent functional modification of hydroxyl group to NHC–Pd complex. The polymeric material had high stability and swelling capacity in a wide range of solvents, even in water. Similar to supported higher generation dendrimer, the newly developed system showed high palladium content with uniformly distributed and well isolated metal nanocentres. The palladium content was found to be 2.02?mmol/g which was comparatively higher than other heterogeneous NHC–Pd based catalysts and the polymer was used as heterogeneous palladium catalyst for Suzuki coupling reaction. Various factors affecting the catalyst’s performance were studied. The high availability and increased accessibility of catalytic sites, stability and dendrimer like property of the polymeric support, reusability, better resistance to metal leaching, easy synthesis etc. are the important features of this newly synthesized catalytic system. Graphical Abstract: [Figure not available: see fulltext.]
Aminomethylpyridinequinones as new ligands for PEPPSI-type complexes
Gajda, Roman,Poater, Albert,Brotons-Rufes, Artur,Planer, Sebastian,Wo?niak, Krzysztof,Grela, Karol,Kajetanowicz, Anna
, p. 138 - 156 (2021/03/22)
A set of six new catalysts possessing quinone moieties in a pyridine ligand was synthesized and fully characterized by standard analytical techniques, including X-Ray crystallography. The results obtained in Suzuki and Mizoroki–Heck cross-coupling reactions catalyzed by quinone-based compounds were comparable to these obtained in the presence of the original PEPPSI complex designed by Organ. DFT calculations allow to see the structural and electronic factors to describe their similarity. On the other hand, steric maps and NCI plots were the tools to have a more global view of the systems studied, leaving the sphere of reactivity around the metal.
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity
Becker, Katja,Benvenuti, Manuela,Bossis, Guillaume,Conde, Pierre-Alexis,Crowder, Michael W.,Dillenberger, Melissa,Docquier, Jean-Denis,Gavara, Laurent,Hernandez, Jean-Fran?ois,Legru, Alice,Mangani, Stefano,Pozzi, Cecilia,Sannio, Filomena,Tassone, Giusy,Thomas, Caitlyn A.,Verdirosa, Federica
supporting information, (2021/10/12)
Metallo-β-lactamases (MBLs) are important contributors of Gram-negative bacteria resistance to β-lactam antibiotics. MBLs are highly worrying because of their carbapenemase activity, their rapid spread in major human opportunistic pathogens while no clinically useful inhibitor is available yet. In this context, we are exploring the potential of compounds based on the 1,2,4-triazole-3-thione scaffold as an original ligand of the di-zinc active sites of MBLs, and diversely substituted at its positions 4 and 5. Here, we present a new series of compounds substituted at the 4-position by a thioether-containing alkyl chain with a carboxylic and/or an aryl group at its extremity. Several compounds showed broad-spectrum inhibition with Ki values in the μM to sub-μM range against VIM-type enzymes, NDM-1 and IMP-1. The presence of the sulfur and of the aryl group was important for the inhibitory activity and the binding mode of a few compounds in VIM-2 was revealed by X-ray crystallography. Importantly, in vitro antibacterial susceptibility assays showed that several inhibitors were able to potentiate the activity of meropenem on Klebsiella pneumoniae clinical isolates producing VIM-1 or VIM-4, with a potentiation effect of up to 16-fold. Finally, a selected compound was found to only moderately inhibit the di-zinc human glyoxalase II, and several showed no or only moderate toxicity toward several human cells, thus favourably completing a promising behaviour.
