713-02-0Relevant academic research and scientific papers
Visible-light-induced regio- And stereoselective C(sp2)-H trifluoroethylation of enamides with 2,2,2-trifluoroethyl iodide
Zhao, Kai,Zhang, Ze-Yu,Cui, Xian-Lu,Wang, Ying-Xue,Wu, Xian-Dan,Li, Wei-Ming,Wu, Jia-Xu,Zhao, Li-Li,Guo, Jing-Yu,Loh, Teck-Peng
, p. 9029 - 9035 (2020)
A photoredox-catalyzed regio- and stereoselective trifluoroethylation reaction of enamides using commercially available 2,2,2-trifluoroethyl iodide as trifluoroethylating agents has been developed, furnishing geometrically defined and synthetically and physiochemically pivotal β-trifluoroethylated enamides bearing a diverse range of functional groups.
Unexpected rearrangements and a novel synthesis of 1,1-dichloro-1-alkenones from 1,1,1-trifluoroalkanones with aluminium trichloride
Lansbergen, Beatrice,Meister, Catherine S.,McLeod, Michael C.
supporting information, p. 404 - 409 (2021/03/20)
A novel reactivity of 1,1,1-trifluoroalkanones is reported, where the reaction with AlCl3 results in the formation of 1,1-dichloro-1-alkenones. The reaction scope was found to be broad, with various chain lengths and aryl substituents tolerated. For substrates containing an electron-rich aromatic ring, further reactions take place, resulting in bicyclic and/or rearrangement products.
Oxidation of 4-Aryl-1,1,1-trifluorobut-2-en-2-yl Trifluoro?-methanesulfonates by 4-Picoline-N-Oxide: A Novel Approach to β-Trifluoromethyl-α,β-enones
Li, Dong,Lv, Shujun,Qu, Jingping,Zhou, Yuhan
, p. 1203 - 1210 (2020/04/15)
An efficient approach to β-trifluoromethyl-α,β-enones via oxidation of 4-aryl-1,1,1-trifluorobut-2-en-2-yl trifluoromethanesulfonates is described. The reaction proceeds smoothly under mild and metal?-free conditions and tolerates a wide range of functional groups. Various β-trifluoromethyl-α,β-enones were obtained in moderate to good yields.
A Novel Ketonitrile Synthesis by Palladium-Catalyzed Carbonylative Coupling Reactions of Amides with Arylboronic Acids
Mai, Wen-Peng,Liu, Yang,Sui, Hong-Dai,Xiao, Yong-Mei,Mao, Pu,Lu, Kui
supporting information, p. 7814 - 7819 (2019/12/24)
A novel, efficient, and simple procedure to synthesize diverse ketonitriles by palladium-catalyzed Suzuki coupling of amides through N–C cleavage has been developed. This procedure features mild conditions, a broad substrate scope, and easily prepared substrates, providing a simple and efficient access to a variety of ketonitriles.
Efficient AcrH2 Catalyzed β-Trifluoromethylation of Carbonyl Compounds by Atom Transfer Radical Addition Reactions
Rao, Zi-Peng,Sun, Yu-Yang,Zhou, Xin-Feng,Xie, Qiang,Zhu, Hui-Xia,Dai, Jian-Jun,Xu, Jun,Xu, Hua-Jian
, p. 1025 - 1030 (2019/08/30)
The use of organic catalysis AcrH2 enables the direct β-trifluoromethylation of carbonyl compounds by atom transfer radical addition reactions with broad substrate scopes under mild conditions. This operationally simple and robust protocol successfully converts a variety of β-chloro carbonyl compounds into the corresponding α-chloro-β-fluoroalkylcarbonyl products. A significant advantage of this method is that it does not require the use of a metal catalyst, thereby avoiding metal residue problems in drug synthesis.
Base-Promoted Double-Bond-Migration/Hydrolysis/Isomerization of 4-Aryl-1,1,1-trifluorobut-2-en-2-yl Trifluoromethanesulfonates: A Metal-Free Approach to β-Trifluoromethyl Ketones
Zhou, Yuhan,Zhang, Chunxia,Zhao, Yilong,Li, Dong,Zhao, Jinfeng,Wang, Zhaotian,Qu, Jingping
, p. 6217 - 6222 (2018/11/23)
A method for the synthesis of β-trifluoromethyl ketones promoted by a base is described. In the presence of DBU, 1-aryl-4,4,4-trifluoromethylbutanones with various functional groups were obtained through the reaction of 4-aryl-1,1,1-trifluorobut-2-en-2-yl
Preparation method of 1-aryl-4,4,4-trifluoro-1-butanone compound
-
Paragraph 0045-0047; 0093-0128, (2018/11/10)
The invention relates to a preparation method of a 1-aryl-4,4,4-trifluoro-1-butanone compound and belongs to the field of compound preparation. The preparation method is characterized by comprising the following steps of by taking trifluoromethyl-substituted enol sulfonate as a compound shown in a general formula II as a raw material, synthesizing 1-aryl-4,4,4-trifluoro-1-butanone as a compound shown in a general formula I: the formula l is shown in the description. The method provided by the invention provides a method which is convenient and is low in cost for synthesis of the 1-aryl-4,4,4-trifluoro-1-butanone compound and avoids using an expensive metal catalyst reagent.
Synthesis of β-CF 3 Ketones through Copper/Silver Cocatalyzed Oxidative Coupling of Enol Acetates with ICH 2 CF 3
Xiong, Yi,Chen, De,Zeng, Sheng,Cheng, Chaozhihui,Wang, Pengjie,Deng, Wei,Xiang, Jiannan,Yi, Niannian
supporting information, p. 2279 - 2282 (2018/10/20)
A simple method for the synthesis of β-CF 3 ketones through copper/silver cocatalyzed oxidative coupling of enol acetates with ICH 2 CF 3 has been developed. Enol acetates were chosen as the source of carbonyl group, giving the β-CF 3 ketones in moderate yields. Control experiments imply that a radical process maybe involved in this reaction.
THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF
-
Page/Page column 340; 341, (2017/08/01)
The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
Silver-Catalyzed Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids
Tan, Xinqiang,Liu, Zhonglin,Shen, Haigen,Zhang, Pei,Zhang, Zhenzhen,Li, Chaozhong
supporting information, p. 12430 - 12433 (2017/09/25)
The silver-catalyzed decarboxylative trifluoromethylation of aliphatic carboxylic acids is described. With AgNO3 as the catalyst and K2S2O8 as the oxidant, the reactions of aliphatic carboxylic acids with (bpy)C
