79606-45-4

Basic information

• Product Name: 4-Chloro-N,N-diisopropylbenzamide
• Synonyms: 4-Chloro-N,N-diisopropylbenzamide;NSC 48107;OR59402 (NSC48107);NSC 4810
• CAS NO: 79606-45-4
• Molecular Formula: C₁₃H₁₈ClNO
• Molecular Weight: 239.75
• Product Categories: blocks;Carboxes
• Mol File: 79606-45-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 347.7°C at 760 mmHg
• Flash Point: 164.1°C
• Appearance: /
• Density: 1.072g/cm³
• Vapor Pressure: 5.28E-05mmHg at 25°C
• Refractive Index: 1.52
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Chloro-N,N-diisopropylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-N,N-diisopropylbenzamide(79606-45-4)
• EPA Substance Registry System: 4-Chloro-N,N-diisopropylbenzamide(79606-45-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 79606-45-4(Hazardous Substances Data)

Usage

General Description

4-Chloro-N,N-diisopropylbenzamide is a chemical compound with the chemical formula C15H21ClNO. It is a white solid with a molecular weight of 269.78 g/mol. 4-Chloro-N,N-diisopropylbenzamide is also known as 4-Chloro-2,6-diisopropylacetanilide, and is commonly used as an intermediate in the synthesis of pharmaceutical compounds. It is a derivative of benzamide and contains a chlorine atom attached to the benzene ring. 4-Chloro-N,N-diisopropylbenzamide is known for its wide range of applications in the pharmaceutical and agrochemical industries as a building block for the synthesis of various organic compounds. It should be handled with care as it may cause irritation to the skin, eyes, and respiratory system, and should be stored in a cool, dry place away from sources of heat and ignition.

InChI:InChI=1/C13H18ClNO/c1-9(2)15(10(3)4)13(16)11-5-7-12(14)8-6-11/h5-10H,1-4H3

Upstream product

• 10364-95-1 1-(4-chloro-benzoyl)-1H-imidazole 
• 108-18-9 diisopropylamine 
• 20383-28-2 N,N-diisopropyl benzamide 
• 1679-18-1 4-Chlorophenylboronic acid 
• 35692-30-9 (4-chlorophenyl)trimethoxysilane 
• 74-11-3 para-chlorobenzoic acid 
• 122-01-0 4-chloro-benzoyl chloride 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 623-03-0 4-Cyanochlorobenzene 
• 5419-55-6 Triisopropyl borate 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 4111-54-0 lithium diisopropyl amide 

Downstream Products

• 1053223-46-3 N,N-diisopropyl 4-chloro-2-dicyclohexylphosphinobenzamide 
• 359445-35-5 N-(4-chlorobenzyl)-N-isopropylpropan-2-amine 
• 20383-28-2 N,N-diisopropyl benzamide 
• 1609554-27-9 N,N-diisopropyl 4-[1-phenyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethyl]benzamide 
• 15563-33-4 4-Chloro-N,N-diisopropyl-thiobenzamide 
• 1557178-60-5 4-chloro-2-cyano-N,N-diisopropylbenzamide 
• 1392473-17-4 4-chloro-2-hydroxy-N,N-diisopropylbenzamide 
• 1375931-26-2 2-bromo-4-chloro-N,N-diisopropylbenzamide 
• 1225544-88-6 4-chloro-N,N-diisopropyl-2-formylbenzamide 
• 1225544-93-3 4-chloro-N,N-diisopropyl-2-(hydroxymethyl)benzamide 
• 74-11-3 para-chlorobenzoic acid 
• 7461-41-8 4-chloro-N-(1-methylethyl)benzamide 
• 17271-13-5 3,4-dichloro-N,N-diisopropylbenzamide 

Relevant articles and documents

Cu-catalyzed arylation of bromo-difluoro-acetamides by aryl boronic acids, aryl trialkoxysilanes and dimethyl-aryl-sulfonium salts: New entries to aromatic amides

We describe a mechanism-guided discovery of a synthetic methodology that enables the preparation of aromatic amides from 2-bromo-2, 2-difluoroacetamides utilizing a copper-catalyzed direct arylation. Readily available and structurally simple aryl precursors such as aryl boronic acids, aryl trialkoxysilanes and dimethyl-aryl-sulfonium salts were used as the source for the aryl substituents. The scope of the reactions was tested, and the reactions were insensitive to the electronic nature of the aryl groups, as both electron-rich and electron-deficient aryls were successfully introduced. A wide range of 2-bromo-2, 2-difluoroacetamides as either aliphatic or aromatic secondary or tertiary amides were also reactive under the developed conditions. The described synthetic protocols displayed excellent efficiency and were successfully utilized for the expeditious preparation of diverse aromatic amides in good-to-excellent yields. The reactions were scaled up to gram quantities.

Visible-Light-Induced, Base-Promoted Transition-Metal-Free Dehalogenation of Aryl Fluorides, Chlorides, Bromides, and Iodides

We report a simple and efficient visible-light-induced transition-metal-free hydrogenation of aryl halides. The combined visible light and base system is used to initiate the desired radical-mediated hydrogenation. A variety of aryl fluorides, chlorides, bromides, and iodides could be reduced to the corresponding (hetero)arenes with excellent yields under mild conditions. Various functional groups and other heterocyclic compounds are tolerated.

Amide Effects in C?H Activation: Noncovalent Interactions with L-Shaped Ligand for meta Borylation of Aromatic Amides

A new concept for the meta-selective borylation of aromatic amides is described. It has been demonstrated that while esters gave para borylations, amides lead to meta borylations. For achieving high meta selectivity, an L-shaped bifunctional ligand has been employed and engages in an O???K noncovalent interaction with the oxygen atom of the moderately distorted amide carbonyl group. This interaction provides exceptional control for meta C?H activation/borylation.