769-27-7

Basic information

• Product Name: 6-AMINO-2,4-DIMETHYL-3-PYRIDINECARBONITRILE
• Synonyms: 6-AMINO-2,4-DIMETHYL-3-PYRIDINECARBONITRILE;6-amino-2,4-dimethylpyridine-3-carbonitrile
• CAS NO: 769-27-7
• Molecular Formula: C₈H₉N₃
• Molecular Weight: 147.17716
• Mol File: 769-27-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 230 °C
• Boiling Point: 314.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.30±0.48(Predicted)
• CAS DataBase Reference: 6-AMINO-2,4-DIMETHYL-3-PYRIDINECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-2,4-DIMETHYL-3-PYRIDINECARBONITRILE(769-27-7)
• EPA Substance Registry System: 6-AMINO-2,4-DIMETHYL-3-PYRIDINECARBONITRILE(769-27-7)

Safety Data

• Hazardous Substances Data: 769-27-7(Hazardous Substances Data)

Usage

General Description

6-AMINO-2,4-DIMETHYL-3-PYRIDINECARBONITRILE is a chemical compound with the molecular formula C9H9N4. It is a pyridine derivative that contains an amino group and a cyano group. 6-AMINO-2,4-DIMETHYL-3-PYRIDINECARBONITRILE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has a yellow-brown color and is typically produced through chemical reactions involving various starting materials. 6-AMINO-2,4-DIMETHYL-3-PYRIDINECARBONITRILE has potential uses in the pharmaceutical and chemical industries due to its reactivity and structural versatility. However, its specific applications and properties may vary depending on the intended use and specific synthesis methods.

Upstream product

• 75-44-5 phosgene 
• 1118-61-2 3-Aminocrotononitrile 
• 372-09-8 cyanoacetic acid 
• 106-93-4 ethylene dibromide 
• 64-19-7 acetic acid 
• 89856-44-0 2-amino-5-bromo-4,6-dimethylpyridine 
• 870-64-4 2-aminocrotononitrile 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 71-43-2 benzene 
• 75-05-8 acetonitrile 
• 925-90-6 ethylmagnesium bromide 
• 75-36-5 acetyl chloride 
• 763-33-7 (E)-3-aminocrotononitrile 

Downstream Products

• 5407-87-4 2-Amino-4,6-dimethylpyridine 
• 1357950-66-3 N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)-2-(phenylamino)oxazole-4-carboxamide 

Relevant articles and documents

Synthesis method of 2-amino-4,6-dimethylpyridine

The invention discloses a synthesis method of 2-amino-4,6-dimethylpyridine. The synthesis method is characterized by comprising the following steps: adding 3-aminocrotononitrile into acetic acid in batches, and carrying out heating for ripening; cooling a reaction liquid, and beginning to decompress and concentrate acetic acid; then adding a concentrated solution into crushed ice, and carrying outsuction filtration, suspension washing and drying on a separated solid to obtain an intermediate; adding the intermediate into a concentrated sulfuric acid solution, and carrying out heating for ripening; carrying out cooling, and dropwise adding pure water for a quenching reaction; pouring a reaction liquid obtained in the previous step into crushed ice, then adding methylbenzene for extractionmultiple times, combining upper-layer organic phases, and sequentially performing washing with saturated sodium chloride, drying, suction filtration and concentration to obtain a crude product; carrying out reduced-pressure solid distillation on the crude product, and collecting a product fraction; and recrystallizing the obtained fraction by using isopropyl ether so as to obtain the white crystalline 2-amino-4,6-dimethylpyridine. According to the prepared high-purity 2-amino-4,6-dimethyl pyridine, GC purity can reach 99% or above, and total yield is 70% or above.

TRICYCLIC PYRAZOLOPYRIDINE COMPOUNDS

In one aspect this invention relates generally to compounds of Formula I and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where

THERAPEUTIC INHIBITORY COMPOUNDS

The invention provides compounds of Formula I and Formula II: A-B-C-D-E-F-G-J (I) C-D-E-F-G-J (II) wherein A, B, C, D, E, F, G, and J have any of the values defined in the specification, and salts thereof. The compounds are useful for inhibiting plasma kallikrein, and for treating a disease or condition in an animal where inhibition of plasma kallikrein is indicated.