785-78-4

Basic information

• Product Name: 4-ACETYLBIBENZYL
• Synonyms: 1-[4-(2-Phenylethyl)phenyl]ethanone;4-ACETYLBIBENZYL;1-[4-(2-phenylethyl)phenyl]ethan-1-one;1-(4-Acetylphenyl)-2-phenylethane;4'-Phenethylacetophenone;4-ACETYLBIBENZYL(WXG02447)
• CAS NO: 785-78-4
• Molecular Formula: C₁₆H₁₆O
• Molecular Weight: 224.3
• EINECS: 212-323-6
• Mol File: 785-78-4.mol
• Article Data: 32

Chemical Properties

• Melting Point: 68 °C
• Boiling Point: 342.7 °C at 760 mmHg
• Flash Point: 146.2 °C
• Appearance: /
• Density: 1.045 g/cm³
• Vapor Pressure: 7.4E-05mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 4-ACETYLBIBENZYL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ACETYLBIBENZYL(785-78-4)
• EPA Substance Registry System: 4-ACETYLBIBENZYL(785-78-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 785-78-4(Hazardous Substances Data)

Usage

Uses

4-Acetylbibenzyl is a useful research intermediate for organic synthesis.

InChI:InChI=1/C16H16O/c1-13(17)16-11-9-15(10-12-16)8-7-14-5-3-2-4-6-14/h2-6,9-12H,7-8H2,1H3

Upstream product

• 83168-79-0 1-phenyl-2-(trifluorosilyl)ethane 
• 99-90-1 para-bromoacetophenone 
• 7439-15-8 1-(4-ethylphenyl)-2-phenylethane 
• 64-19-7 acetic acid 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 75-36-5 acetyl chloride 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 34420-17-2 (2-phenylethyl)boronic acid 
• 100-42-5 styrene 
• 99-91-2 para-chloroacetophenone 
• 13329-40-3 4-Iodoacetophenone 
• 17376-04-4 2-phenethyl iodide 
• 103-63-9 1-phenyl-2-bromoethane 

Downstream Products

• 215368-65-3 1-[4-(2-indolyl)phenyl]-2-phenylethane 
• 55005-38-4 Hexahydro-2-(α-methyl-p-phenethylbenzylimino)-azepine hydrochloride 
• 1381870-28-5 5-phenyl-2-[4-(2-phenylethyl)phenyl]indole 
• 28179-32-0 2-bromo-1-[4-(2-phenylethyl)phenyl]ethanone 
• 94029-37-5 1-Phenyl-2-(4-dibromacetyl-phenyl)-ethan 
• 1353585-92-8 2-(1H-imidazol-1-yl)-1-[4-(2-phenylethyl)phenyl]ethanone hydrochloride 
• 1228271-10-0 4-[5-(4-Phenethyl-phenyl)-isoxazol-3-yl]-benzoic acid 
• 10509-25-8 C₃₂H₂₆ 
• 838862-58-1 1-[4-(1-benzyl-2-indolyl)phenyl]-2-phenylethane 
• 24585-99-7 p-(2-Phenylethyl)-phenyl-glyoxal 
• 10509-24-7 1-ethynyl-4-(2-phenylethyl)benzene 
• 73932-75-9 4'-(β-phenylethyl)-3-(dimethylamino)propiophenone 

Relevant articles and documents

Nickel-Catalyzed Regiodivergent Reductive Hydroarylation of Styrenes

We report a ligand-controlled nickel-catalyzed reductive hydroarylation of styrenes with predictable and controllable regioselectivity. With a diamine ligand, the reaction produces selective linear hydroarylation products. Alternatively, with a chiral PyrOx ligand, branch-selective enantioenriched 1,1-diarylalkane products are obtained. Preliminary mechanistic results are consistent with a reductive Heck process.

"bulky-Yet-Flexible" α-Diimine Palladium-Catalyzed Reductive Heck Cross-Coupling: Highly Anti-Markovnikov-Selective Hydroarylation of Alkene in Air

To pursue a highly regioselective and efficient reductive Heck reaction, a series of moisture-and air-stable α-diimine palladium precatalysts were rationally designed, readily synthesized, and fully characterized. The relationship between the structures of the palladium complexes and the catalytic properties was investigated. It was revealed that the"bulky-yet-flexible"palladium complexes allowed highly anti-Markovnikov-selective hydroarylation of alkenes with (hetero)aryl bromides under aerobic conditions. Further synthetic application of the present protocol could provide rapid and straightforward access to functional and biologically active molecules.

Preparation of Alkyl Indium Reagents by Iodine-Catalyzed Direct Indium Insertion and Their Applications in Cross-Coupling Reactions

An efficient method for the synthesis of alkyl indium reagent by means of an iodine-catalyzed direct indium insertion into alkyl iodide in THF is reported. The thus-generated alkyl indium reagents effectively underwent Pd-catalyzed cross-coupling reactions with various aryl halides, exhibiting good compatibility to a variety of sensitive functional groups. By replacing THF with DMA and using 0.75 equiv of iodine, less reactive alkyl bromide could be used as substrate for indium insertion with equal ease.