42497-88-1

Upstream product

• 27691-43-6 1-(benzylsulphanyl)-4-Nitrobenzene 
• 6140-35-8 2-Chlor-1-<4-nitro-benzolsulfonyl>-1-phenyl-ethylen 
• 100-53-8 phenylmethanethiol 
• 350-46-9 4-Fluoronitrobenzene 
• 13113-79-6 sodium 4-nitrobenzenethiolate 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 100-44-7 benzyl chloride 
• 100-00-5 4-chlorobenzonitrile 
• 937-32-6 4-nitrobenzenesulfenyl chloride 
• 6140-32-5 1-chloro-(E)-2-(p-nitrophenylthio)-2-phenylethylene 
• 636-98-6 p-nitrobenzene iodide 

Downstream Products

• 42497-99-4 (4-Aminophenyl)-benzyl-sulfon 
• 100-02-7 4-nitro-phenol 
• 588-59-0 stilbene 
• 22887-34-9 1,3,5-Trimethoxy-2-(trans-2-phenylethenyl)benzene 
• 4714-26-5 3-nitrostilbene 
• 74809-43-1 1,2,3-trimethoxy-5-styrylbenzene 
• 1466-17-7 3,4-dimethoxystilbene 
• 4714-24-3 1-bromo-4-styrylbenzene 
• 72777-78-7 (3E)-1,4-diphenyl-1,3-butadiene 
• 838-95-9 4-(N,N-dimethylamino)stilbene 
• 4714-25-4 2-nitrostilbene 
• 78916-49-1 1-phenyl-2-(3,5-dimethoxyphenyl)ethene 
• 22257-16-5 1-methyl-2-(2-phenylethenyl)benzene 
• 1657-53-0 cis-4-methoxystilbene 

Relevant academic research and scientific papers

Borax-catalyzed and pH-Controlled selective oxidation of organic sulfides by H2O2: An environmentally clean protocol

The selective oxidation of sulfides to sulfoxides and sulfones was achieved in high yields at: room temperature with borax as a recyclable catalyst and H2O2 as the terminal oxidant by varying the pH of the reaction medium. The borax/H2O2 system can chemoselectively oxidize alkyl and aryl sulfides in the presence of oxidation-prone functional, groups such as C=C, -CN, and -OH.

SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

Sodium hypochlorite-promoted novel synthesis of organic ammonium tribromides and application of phenanthroline hydrotribromide in chemoselective oxidation of organic sulfides by hydrogen peroxide

A novel method of synthesis of organic ammonium tribromides (OATBs) is developed by using an inexpensive and eco-friendly sodium hypochlorite as oxidant for conversion of Br to Br3 . The OATBs thus prepared include both quaternary ammonium tribromides and N-heterocyclic tribromides. A new addition to the family of OATBs is made in the form of phenanthroline hydrotribromide. The efficacy of this new tribromide as catalyst is ascertained in the oxidative transformation of organic sulfides to their corresponding sulfoxides and sulfones by hydrogen peroxide.

Catalytic enantioselective oxidation of bulky alkyl aryl thioethers with H2O2 over titanium-salan catalysts

A simple and efficient catalytic procedure for the oxidation of bulky (preferably aryl benzyl substituted) thioethers with hydrogen peroxide in good to high yields and enantioselectivities (up to 98.5%ee) is reported. The high optical yields are achieved in a tandem stereoconvergent enantioselective oxidation and kinetic resolution process. A reasonable balance between the sulfoxide yield and enantioselectivity could be found by varying the concentration and temperature. An improved synthesis of the titanium-salan catalysts for the preparation of a more stereoselective catalyst is reported.

Synthesis of 4-nitrophenyl sulfones and application in the modified Julia olefination

4-Nitrophenyl (NP) sulfones have been successfully employed in the modified Julia olefination reaction with carbonyl compounds. The olefination reaction proceeds through a sequence of aldol addition, Smiles rearrangement, and elimination. The sulfones are easily prepared in high yields in a two-step sequence starting from inexpensive commercially available para- fluoronitrobenzenes via nucleophilic aromatic substitution by a mercaptane and subsequent oxidation under standard conditions. The modified Julia reaction between NP sulfones and a wide variety of aromatic aldehydes affords the corresponding styrenes, stilbenes and cinnamate derivatives in yields up to 97% and good stereoselectivities. A mechanistic rationale is advanced to explain the observed results. Georg Thieme Verlag Stuttgart.

A tandem Michael addition-rearrangement-carbonylation by (4-nitrophenylsulfonylmethyl) benzene and its derivatives with methacrylates under PTC

A novel tandem Michael addition-rearrangement-carbonylation was studied in the reaction of (4-nitro-phenylsulfonylmethyl)benzene(1) and its derivatives with methacrylates (2) under solid-liquid PTC conditions and a probable mechanism is discussed.

Photooxidation of alkyl 4-nitrophenyl sulfides and sulfoxides. Observation of oxidative C-S bond cleavage and rearrangement reactions

Alkyl 4-nitrophenyl sulfides and sulfoxides undergo a self-photoinduced, singlet oxygen oxidation to produce a variety of products, including sulfonates and carbonyl compounds formed by the oxidative cleavage of the C-S bond of the sulfides and sulfoxides. Structural rearrangements are observed in the resulting carbonyl compounds formed in the oxidative cleavage of the C-S bond in the tert-amyl and 2-phenylethyl sulfides. An overall mechanism is proposed which involves the formation of peroxysulfoxides and peroxysulfones which undergo heterolytic C-S bond cleavage to form ion pairs which recombine to form persulfenates or persulfinates which then undergo photo- and/or thermallyinduced homolytic O-O bond cleavage to form alkoxy and sulfinyl or sulfonyl radicals. The alkoxy radicals undergo β-scission, disproportionation, or recombination with the sulfonyl radical to form the observed products. These C-S oxidative cleavage reactions have only been rarely observed in the earlier studies on the singlet oxygen oxidation studies of dialkyl sulfides, and are attributed, in part, to the presence of the 4-nitro group on the aromatic ring which greatly affects the susceptibility of the sulfur atom of the sulfides and sulfoxides toward nucleophilic attack, and on the reactivity of the peroxysulfoxides and peroxysulfones toward heterolytic cleavage of the O-S bond.

Ring Contractions of Thiochroman-4-ones and Thiochromen-4-ones

3-Bromothiochroman-4-one and its S-oxide undergo ring contraction on heating, especially in the presence of sodium acetate, to give mixtures which include thioindigo (9) and the ethanediylidenethioindigo (10).Brominated 2,2-dimethylthiochroman-4-one reacts on silica gel to form thioindigo, thioindirubin, and the bis(benzothieno)pyran (17).Bromination of thiochromanone gives a number of products, including 2,3-dibromothiochromen-4-one S-oxide which, on heating with sodium acetate in acetic acid, is converted efficiently into thioindigo.The mechanism of this reaction is investigated.