81265-93-2

Basic information

• Product Name: 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine
• Synonyms: 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine;N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine;5'-DMT-2'-TBDMS-Bz-rA;N-(9-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-3-((tert-butyldiMethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzaMide;2'-O-t-ButyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-N6-benzoyl adenosine;N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-[(1,1-diMethylethyl)diMethylsilyl]-Adenosine;N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-but ldimethylsilyl)o;N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine
• CAS NO: 81265-93-2
• Molecular Formula: C₄₄H₄₉N₅O₇Si
• Molecular Weight: 787.97466
• EINECS: 2017-001-1
• Mol File: 81265-93-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.87±0.43(Predicted)
• CAS DataBase Reference: 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine(81265-93-2)
• EPA Substance Registry System: 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine(81265-93-2)

Safety Data

• Hazardous Substances Data: 81265-93-2(Hazardous Substances Data)

Usage

Uses

5''-O-DMT-2''-O-TBDMS-N-Bz-Adenosine (CAS# 81265-93-2) is a fluorescent adenosine-containing compound which is often used in for DNA/RNA modifications for detection or the addition of synthetic oligonucleotide blocks.

Upstream product

• 129666-75-7 6-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)adenosine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 69504-07-0 N⁶-benzoyl-2'-O-(tert-butyldimethylsilyl)adenosine 
• 4546-55-8 N-benzoyladenosine 
• 1348775-39-2 adenosine 
• 98-88-4 benzoyl chloride 
• 58-61-7 adenosine 
• 401812-98-4 3’,5’-O-bis(t-butylsilyl)-2’-O-(t-butyldimethylsilyl)-N6-benzoyladenosine 
• 212375-93-4 3’,5’-O-bis(t-butylsilyl)-2’-O-(t-butyldimethylsilyl)adenosine 
• 97219-09-5 3',5'-O-(Di-tert-butylsilanediyl)adenosine 

Downstream Products

• 104992-55-4 N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) 
• 131316-88-6 Succinic acid mono-[(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl] ester 
• 100638-43-5 Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester 
• 136044-34-3 N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine 3'-O-(2-cyanoethyl N,N-diethylphosphoramidite) 
• 127553-42-8 5'-O-DMTr-2'-O-TBDMS-N-Bz-adenosine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt 
• 75074-02-1 N⁶-Benzoyl-2'-O-(tert-butyldimethylsilyl)adenosin-3'-(o-chlorphenyl)(β-cyanethyl)phosphat 
• 1374755-65-3 C₅₇H₆₅N₆O₈PS₂Si 
• 1222078-42-3 C₅₂H₅₄N₈O₈Si 
• 1005482-73-4 (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl trifluoromethane-sulfonate 
• 118380-97-5 C₄₇H₅₈N₇O₁₃PSi*H₃N 

Relevant articles and documents

CYCLIC DINUCLEOTIDE COMPOUND AND USES THEREOF

Provided are a compound of formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, uses of said compound acting as a STING agonist.

CYCLIC DI-NUCLEOTIDE COMPOUNDS AND METHODS OF USE

Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

Synthesis of 2'-O-substituted ribonucleosides.

An efficient synthesis of 2'-O-substituted ribonucleosides, including 2'-O-TBDMS and 2'-O-TOM protected as well as 2'-O-Me and 2'-O-allyl derivatives is presented. Di-t-butylsilylene group was employed for simultaneous protection of 3'- and 5'- hydroxyl functions of nucleoside on the first step. Subsequent silylation or alkylation of free 2'-OH followed by introduction of suitable protection on the base moiety and removal of cyclic silyl protection gave target compounds in a high yield.