85221-16-5

Basic information

• Product Name: propan-2-yl (4-methoxyphenyl)carbamate
• CAS NO: 85221-16-5
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.2417
• Mol File: 85221-16-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 266.3°C at 760 mmHg
• Flash Point: 114.9°C
• Density: 1.123g/cm³
• Vapor Pressure: 0.0087mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: propan-2-yl (4-methoxyphenyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: propan-2-yl (4-methoxyphenyl)carbamate(85221-16-5)
• EPA Substance Registry System: propan-2-yl (4-methoxyphenyl)carbamate(85221-16-5)

Safety Data

• Hazardous Substances Data: 85221-16-5(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 292638-85-8 acrylic acid methyl ester 
• 3532-17-0 4-methoxybenzoyl azide 
• 67-63-0 isopropyl alcohol 
• 2446-83-5 di-isopropyl azodicarboxylate 
• 104-94-9 4-methoxy-aniline 
• 5720-07-0 4-methoxyphenylboronic acid 
• 201230-82-2 carbon monoxide 
• 2101-87-3 p-methoxy-phenylazide 
• 10364-93-9 1-(4-methoxybenzoyl)-imidazole 
• 100-09-4 4-methoxybenzoic acid 
• 10507-69-4 4-methoxybenzohydroxamic acid 
• 590-28-3 potassium cyanate 

Downstream Products

• 5327-53-7 4 hydroxy Probham 

Relevant articles and documents

Direct conversion of carboxylic acids to various nitrogen-containing compounds in the one-pot exploiting curtius rearrangement

Herein we report, a single-pot multistep conversion of inactivated carboxylic acids to various N-containing compounds using a common synthetic methodology. The developed methodology rendered the use of carboxylic acids as a direct surrogate of primary amines, for the synthesis of primary ureas, secondary/tertiary ureas, O/S-carbamates, benzoyl ureas, amides, and N-formyls, exploiting the Curtius reaction. This approach has a potential to provide a diversified library of N-containing compounds, starting from a single carboxylic acid, based on the selection of the nucleophile.

Copper-catalyzed carbonylation of anilines by diisopropyl azodicarboxylate for the synthesis of carbamates

A Cu-catalyzed efficient methodology for the direct carbonylation of anilines has been developed. The N-H bond cleavage and N-C bond formation were notably achieved under solvent-free conditions and a variety of carbamates were synthesized from readily available anilines using diisopropyl azodicarboxylate (DIAD) as the carbonylating source.

N-methylimidazole-catalyzed synthesis of carbamates from hydroxamic acids via the lossen rearrangement

An efficient, one-pot, N-methylimidazole (NMI) accelerated synthesis of aromatic and aliphatic carbamates via the Lossen rearrangement is reported. NMI is a catalyst for the conversion of isocyanate intermediates to the carbamates. Moreover, the utility of arylsulfonyl chloride in combination with NMI minimizes the formation of often-observed hydroxamate-isocyanate dimers during the sequence. Under the present conditions, lowering of temperatures is also possible, enabling a mild protocol.