867-54-9

Usage

Physical state

Colorless to pale yellow liquid

Odor

Pungent

Solubility

Soluble in water

Reactivity

Highly reactive

Toxicity

Highly toxic

Uses

Primarily used as a reagent in organic chemical synthesis

Hazardous nature

Strong irritant to skin, eyes, and respiratory system

Health effects

Can cause severe damage to liver and kidneys

Safety precautions

Handle and store with extreme care, following strict safety guidelines

Upstream product

• 67-64-1 acetone 
• 598-31-2 1-bromoacetone 
• 67-56-1 methanol 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 7647-01-0 hydrogenchloride 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 99842-95-2 2-acetyl-3-phenyl-thiazolidin-4-one 
• 3475-39-6 1,1,3-tribromoacetone 
• 3770-98-7 1,1,1-tribromopropan-2-one 
• 4215-07-0 7-methyl-2,4-diaminopteridine 
• 708-74-7 2,4-diamino-6-methylpteridine 
• 816-39-7 1,3-dibromoroacetone 
• 598-31-2 1-bromoacetone 
• 1003322-14-2 1,1-dibromo-2-tosyloxypropene 

Relevant academic research and scientific papers

PROCESS FOR PREPARIING 1,3-DIBROMOACETONE, 1-3-DICHLOROACETONE AND EPICHLOROHYDRIN

A process for preparing 1,3-dibromoacetone, 1-3-dichloroacetone and epichlorohydrin which comprises: (a) reacting acetone with 2 moles of bromine to make a mixture of brominated acetone derivatives and byproduct hydrogen bromide; (b) equilibrating the mixture of brominated acetone derivatives and hydrogen bromide to produce 1,3-dibromoacetone as the major product; (c) crystallizing the 1,3-dibromoacetone; and (d) isolating the 1,3-dibromoacetone. The process may further include the steps of (e) reacting the 1,3-dibromoacetone with a chloride source to produce 1,3-dichloroacetone; (f) hydrogenating the isolated 1,3-dichloroacetone to produce 1,3-dichlorohydrin; and (g) cyclizing the 1,3-dichlorohydrin with a base to produce epichlorohydrin.

Oxybromination Catalysed by the Heteropolyanion Compound H5PMo10V2O40 in an Organic Medium: Selective para-Bromination of Phenol

Selective bromination of phenol and its derivatives and the bromination of ketones and alkenes have been achieved by oxybromination at ambient conditions catalysed by the mixed addenda heteropolyanion compound H5PMo10V2O40, which is dissolved in a nonpolar chlorohydrocarbon solvent by complexation with tetraglyme.

Chlorination of Aliphatic Ketones in Methanol

The chlorination of aliphatic ketones in methanol has been examined.The product distributions in methanol differ substantially from those obtained by chlorination in carbon tetrachloride.The reaction in methanol favors addition of chlorine to the least substituted carbon α to the carbonyl group.The effect is especially pronounced if an α carbon bearing two substituents is present.The distribution of products is determined by the relative stability of the enol ethers formed from the ketone under the reaction conditions.