89141-15-1

Upstream product

• 87378-63-0 (Z)-2-methyl-4-(α-phenylethylidene)-5-(4H)-oxazolone 
• 124-41-4 sodium methylate 
• 96791-17-2 cis-4-phenyl-3-acetamido-3-carbomethoxy-Δ¹-pyrazoline 
• 39687-95-1 isocyanoacetic acid methyl ester 
• 75-36-5 acetyl chloride 
• 98-86-2 acetophenone 
• 60676-51-9 methyl (Z)-2-(acetylamino)-3-phenylpropenoate 
• 686744-70-7 (Z)-2-acetylamino-3-iodo-but-2-enoic acid methyl ester 
• 98-80-6 phenylboronic acid 
• 3373-59-9 L-threonine methyl ester 
• 57294-56-1 (Z)-methyl 2-acetamido-3-methoxyacrylate 

Downstream Products

• 118251-80-2 2-Acetylamino-3-phenyl-butyric acid methyl ester 
• 171597-45-8 (2S,3R)-2-acetylamino-3-phenyl-butyric acid methyl ester 
• 25488-27-1 threo-L-(2S,3R)-β-methylphenylalanine 
• 59850-51-0 (2R,3S)-2-amino-3-phenyl-butyric acid hydrochloride 
• 59850-51-0 threo-(+)-(2S,3R)-L-β-Methylphenylalanine hydrochloride 
• 25488-26-0 erythro-D-(2R,3R)-β-methylphenylalanine 
• 25488-25-9 (2S,3S)-methylphenylalanine 
• 686744-85-4 (2R,3S)-2-acetylamino-3-phenyl-butyric acid methyl ester 

Relevant academic research and scientific papers

A Versatile Chemo-Enzymatic Route to Enantiomerically Pure β-Branched α-Amino Acids

A series of diastereoisomers of β-methyl-β-phenylalanine analogues 1a?f have been prepared in enantiomerically pure form using a combination of chemo- and biocatalysis. Starting from l-threonine methyl ester 2, a range of β,β-disubstituted didehydroamino

Catalytic asymmetric hydrogenation of α-(acetamido)acrylates using TRAP trans-chelating chiral bisphosphine ligands: Remarkable effects of ligand P-substituent and hydrogen pressure on enantioselectivity

The catalytic asymmetric hydrogenation of α-(acetamido)acrylates was carded out with the rhodium complexes prepared from [Rh(cod)2]BF4 and trans-chelating chiral bisphosphine ligands, (S,S)-2,2'-bis[(R)-1-(dialkylphosphino)ethyl]-1,1

ON THE SYNTHESIS OF METHYL (Z/E)-2-ACETAMIDO(OR BENZAMIDO)-3-ARYL 2-BUTENOATES

The methyl Z-2-acetamido(or benzamido)-3-aryl-2-butenoates (Z-9a-e, Z-10a-e) were obtained by two alternative procedures: stereospecific opening of Z-2-methyl(or phenyl)-4-(α-arylethylidene)-5(4H)-oxazolones (Z-7a-e, Z-8a-e) and stereospecific homologatio

Synthesis of Methyl (Z)-2-Acetamido-3-aryl-2-butenoates in Two Highly Selective Steps

Diazomethane reacts with methyl (Z)-2-acetamido-3-aryl-2-propenoates regio- and stereospecifically to afford cis-4-aryl-3-acetamido-3-methoxycarbonyl-Δ1-pyrazolines which heated in 1,2-ethanediol at 200 deg C extrude nitrogen to afford stereospecifically methyl (Z)-2-acetamido-3-aryl-2-butenoates in high yields.

Action of Diazomethane on Methyl (Z(or E))-2-(Acylamino)cinnamates. A New Route to Methyl (Z)-2-(Acylamino)-3-methylcinnamates

Diazomethane reacts with methyl (Z(or E))-2-acetamido(or benzamido)cinnamates (1,2) to afford regio- and stereospecifically (Z(or E))-4-phenyl-3-acetamido(or benzamido)-3-carbomethoxy-Δ1-pyrazolines (3,4). 3Z and 4Z undergo pyrolysis to afford