Various Synthetic Approaches to Oximes Formation and Their Common Transformations

February 19, 2024

• Title:       

  Various Synthetic Approaches to Oximes Formation and Their Common Transformations

• Image Source:

  New approach to oximes through reduction of nitro compounds enabled by visible light photoredox catalysis

• Mark:

  Scheme 1

• Associated context:

  As shown in Scheme 1, traditionally, direct condensations of an aldehyde or a ketone with hydroxylamine are the most frequently employed method. An alternative is the reduction of primary nitroalkanes, as well as α,β-unsaturated nitrocompounds, to oximes involving the use of Se/NaBH4, Bu3SnH, SnCl2/PhSH, or Au/TiO2/H2. Therefore, a strong need remains for mild, convenient methods for oxime synthesis.