Reduction of OH-Protected 3-Oxoketoxime

August 21, 2024

• Title:       

  Reduction of OH-Protected 3-Oxoketoxime

• Image Source:

  Halonium ion mediated synthesis of 2-halomethylene-3-oxoketoxime derivatives from isoxazoline N-oxides

• Mark:

  Scheme 5

• Associated context:

  Next, we protected the OH functionality of compound 1a  with acetate to obtain the Baylis−Hillman oxime acetate  (Scheme 5). However, on treatment with LAH, compound 1e underwent acetate deprotection and reduction to produce compound 1c in poor yield.