Synthesis of 2-hydroxy-5,6-diarylnicotinonitriles and 2-chloro-5,6-diarylnicotinonitriles from β-chloroenones
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Add time:07/19/2019 Source:sciencedirect.com
Vilsmeier–Haack reaction of β-ketoaldehydes leads to the formation of β-chloroenones and these chloroenones on treatment with malononitrile afford 2-hydroxy-5,6-diarylnicotinonitriles. But a one-pot reaction of β-ketoaldehydes with Vilsmeier–Haack reagent and malononitrile or cyanoacetamide results in the formation of 2-chloro-5,6-diarylnicotinonitriles in good yields.
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