Regioselective functionalization of 2-(2′-fluorophenyl)-3-cyanopyridine and its cyclization to benzo[h]-1,6-naphthyridines
-
Add time:07/22/2019 Source:sciencedirect.com
Benzo[h]-1,6-naphthyridines and 5-ones, selectively functionalized at C-2, C-3, C-5 and C-10, were obtained by alkyllithium-, lithium amide- or potassium hydroxide-induced anionic cyclization of 3-cyano-2-(2-fluorophenyl)pyridine, which was functionalized regioselectively at positions 4, 5, 6, and 6′.
We also recommend Trading Suppliers and Manufacturers of 2-CHLORO-6-METHYL-5-PHENYLNICOTINONITRILE (cas 10176-63-3). Pls Click Website Link as below: cas 10176-63-3 suppliers
Prev:Ultrasound-assisted one-pot four-component synthesis of novel 2-amino-3-cyanopyridine derivatives bearing 5-imidazopyrazole scaffold and their biological broadcast
Next:Ultrasound-promoted an efficient method for one-pot synthesis of 2-amino-4,6-diphenylnicotinonitriles in water: A rapid procedure without catalyst) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Microwave-assisted synthesis and transformations of sterically hindered 3-(5-tetrazolyl)pyridines07/25/2019
- Structure–activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 507/24/2019
- Ultrasound-promoted an efficient method for one-pot synthesis of 2-amino-4,6-diphenylnicotinonitriles in water: A rapid procedure without catalyst07/23/2019
- Ultrasound-assisted one-pot four-component synthesis of novel 2-amino-3-cyanopyridine derivatives bearing 5-imidazopyrazole scaffold and their biological broadcast07/20/2019
- Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: Discovery and computational modeling of a new series of ligands with nanomolar affinity07/21/2019
- Synthesis of 2-hydroxy-5,6-diarylnicotinonitriles and 2-chloro-5,6-diarylnicotinonitriles from β-chloroenones07/19/2019
