Metabolism of 5α-androstane-3β,17β-diol to 17β-hydroxy-5α-Androstan-3-one (cas 1224-95-9) and 5α-androstan-3α,17β-diol in the rat

Add time:07/27/2019    Source:sciencedirect.com

Significant metabolism of 5α-androstane-3β,17β-diol to 17β-hydroxy-5α-androstan-3-one was recorded in several tissues and organs from rats and humans. This bioconversion was further investigated in rat testis homogenates. 5α-Androstane-3β,17β-diol was readily metabolized to 17β-hydroxy-5α-androstan-3-one with NAD and/or NADP added as cofactors. When a NADPH generating system was included in the incubation, 5α-androstane-3β,17β-diol was metabolized to 5α-androstan-3α,17β-diol. Only small amounts of 17β-hydroxy-5α-androstan-3-one accumulated under the latter condition.

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