Liquid chromatographic determination of ceterizine hydrochloride and paracetamol in human plasma and pharmaceutical formulations

Add time:07/27/2019    Source:sciencedirect.com

An accurate, simple, reproducible and sensitive HPLC method for the determination of ceterizine hydrochloride (CTZH) and paracetamol (PARA) has been developed and validated. The separation of CTZH, PARA and Nimesulide (the internal standard) was achieved on a CLC C18 (5 μ, 25cm×4.6 mm i.d) column using UV detection at 230 nm. The mobile phase was consisted of acetonitrile–water (55:45 v/v). The linear ranges of detection for CTZH and PARA were found to be 0.715–55 μg/ml (r2=0.9985) and 0.55–39 μg/ml (r2=0.9957) respectively. Intra- and inter-day assay relative standard deviations were less than 1%. The method has been applied successfully to the determination of binary combination of CTZH and PARA in human plasma and pharmaceutical preparations. There was no interference from drugs commonly administered with CTZH and PARA. The method has been shown to be linear, reproducible, specific, and rugged.

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