Gold(III) complexes of amides of EDTA (L, L1) and PDTA (L2, L3) as model systems for gold(III)–peptide/protein interactions.

Add time:08/02/2019    Source:sciencedirect.com

Reaction of 1,2-diaminoethane-N,N,N′,N′-tetra-(N-methylacetamide), L, with K[AuCl4] in water gave the complex [AuLCl2][AuCl4] which when recrystallised from MeOH/H2O gave the amidate-containing complex [Au(LH−1)Cl][AuCl4] the crystal structure of which shows LH−1 to be present as a tridentate ligand coordinated via its amino group nitrogens and a deprotonated amide group. The geometry around the metal ion in both cation and anion is square planar with bond lengths, AuN (amine)=2.06(1) and 2.105(9) Å, AuN (amidate)=2.00(2) Å, AuCl in the cation 2.274(3) and in the anion 2.262(4)–2.278(5) Å. As very few crystal structures of gold(III)–peptide complexes have so far been reported this serves as a model compound for Au(III)–peptide/protein interactions. It is also the first reported structure of a Au(III) complex with tertiary amine donor groups. Reaction of [Au(LH−1)Cl][AuCl4] with dilute HCl in methanol–water gave the complex (LH2)2[AuCl4]3.5[AuCl2]0.5·2H2O, the crystal structure of which confirms the presence of doubly protonated L cations and tetrachlorogold(III) and dichlorogold(I) anions. The synthesis of [AuL1Cl2][AuCl4]·2H2O, [AuL2Cl2]Cl·H2O, [AuL3Cl2]Cl·CH3OH where L1 is 1,2-diaminoethane-N,N,N′,N′-tetra-acetamide, L2 is 1,2-diaminopropane-N,N,N′,N′-tetra-acetamide and L3 is 1,2-diaminopropane-N,N,N′,N′-tetra-(N-methylacetamide) are also reported.

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