Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines

Add time:07/29/2019    Source:sciencedirect.com

The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relationship study indicated the necessity of the chlorine at the C4-position for biological activity. The two most active compounds 1 and 2 were found to induce apoptosis in the leukemia L1210 cell line. Additionally, the compounds were screened against a variety of other microbial targets and as a result, selective activity against several fungi was also observed. The synthesis and preliminary biological results are reported herein.

We also recommend Trading Suppliers and Manufacturers of 4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE (cas 16234-40-5). Pls Click Website Link as below: cas 16234-40-5 suppliers

Prev:Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110α inhibitors
Next:Characterization of aklavinone (cas 16234-96-1)-11-hydroxylase from Streptomyces purpurascens)