Labelling of biologically active molecules with a cyclohexadiene tricarbonyl iron unit

Add time:07/31/2019    Source:sciencedirect.com

Tricarbonyl cyclohexa-1,3-diene iron(0) derivatives of two biologically active molecules, N-acetyl cysteine and N-acetyl histamine and of a primary amine, n-butylamine, have been prepared by reaction of [tricarbonyl (1-4-η-5-N-pyridiniocyclohexa-1,3-diene) iron] tetrafluoroborate, a precursor of the highly reactive cation [Fe(CO)3(1-5-η-C6H7)](+), and characterized spectroscopically. Kinetic studies revealed that the reaction of N-acetyl histamine and n-butylamine was much faster than the reaction of N-acetyl cysteine. Acid/base titration of metal-carbonyl labelled histamine was achieved by IR spectroscopy and revealed that the imidazole ring substituted by the metal-carbonyl unit was slightly more basic than the parent compound. To cite this article: M. Mokhtari et al., C. R. Chimie 8 (2005).

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